PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146414 View Pathway	drug action Delamanid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:08 Last Updated: October 07, 2023 at 18:08
PW000715 View Pathway	drug action Delavirdine Action Pathway Homo sapiens Delavirdine (also known as Rescriptor) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that can be used for treating HIV-1. Delavirdine can bind and inhibit the reverse transcriptase so that the DNA polymerase activities can be prevented, which lead to disruption of the enzyme's catalytic site and eventually lead to prevention of cell growth. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: June 23, 2014 at 06:20 Last Updated: June 23, 2014 at 06:20
PW144817 View Pathway	drug action Delavirdine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:29 Last Updated: October 07, 2023 at 14:29
PW126445 View Pathway	drug action Delavirdine HIV Reverse transcriptase Inhibitor Action Pathway Homo sapiens Delavirdine is a potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. When HIV infects a cell, the virus first binds and fuses with the cell, releasing its nucleocapsid containing its RNA and reverse transcriptase into the cytosol of the cell. The reverse transcriptase converts the viral RNA into viral DNA in the cytosol. The viral DNA goes to the nucleus through the nuclear pore complex where it undergoes the process of transcription. The new viral RNA formed from transcription is transported back to the cytosol through the nuclear pore complex and translation occurs to produce viral proteins. These viral proteins are assembled and new HIV viruses bud from the cell. Delavirdine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of delavirdine does not compete with template or nucleoside triphosphates. Inhibiting reverse transcriptase, this prevents the formation of viral DNA. Less viral proteins are therefore produced, and there is a reduction in new viruses being formed. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: December 05, 2021 at 22:07 Last Updated: December 05, 2021 at 22:07
PW176017 View Pathway	metabolic Delavirdine Predicted Metabolism Pathway new Homo sapiens Metabolites of Delavirdine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:16 Last Updated: November 29, 2023 at 13:16
PW124562 View Pathway	metabolic Delete 2 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Rahil Doshi Created On: March 02, 2021 at 01:27 Last Updated: March 02, 2021 at 01:27
PW128008 View Pathway	drug action Demecarium Action Pathway Homo sapiens Demecarium is a cholinesterase inhibitor used in the treatment of glaucoma, acting as an indirect parasympathomimetic agent by increasing acetylcholine levels in the synaptic cleft. The mechanism of action is demecarium the drug acts on acetylcholinesterase and cholinesterase, this increases extracellular levels of acetylcholine stimulating muscarinic receptors that act on g-coupled protein receptors and initiating a downstream cascade of effects. The parasympathetic effect leads the pupil to constrict and stimulate the outflow of aqueous humor reducing intraocular pressure. It is a long-acting cholinesterase and very potent, due to this should only be used in patients with open-angle glaucoma. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: June 29, 2023 at 09:10 Last Updated: June 29, 2023 at 09:10
PW128291 View Pathway	drug action Demecarium Action Pathway (new) Homo sapiens Demecarium is a cholinesterase inhibitor used in the treatment of glaucoma, acting as an indirect parasympathomimetic agent by increasing acetylcholine levels in the synaptic cleft. The mechanism of action is demecarium the drug acts on acetylcholinesterase and cholinesterase, this increases extracellular levels of acetylcholine stimulating muscarinic receptors that act on g-coupled protein receptors and initiating a downstream cascade of effects. The parasympathetic effect leads the pupil to constrict and stimulate the outflow of aqueous humor reducing intraocular pressure. It is a long-acting cholinesterase and very potent, due to this should only be used in patients with open-angle glaucoma. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 15, 2023 at 18:20 Last Updated: August 15, 2023 at 18:20
PW132487 View Pathway	metabolic Demecarium Drug Metabolism Homo sapiens Demecarium is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Demecarium passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:02 Last Updated: September 21, 2023 at 22:02
PW145044 View Pathway	drug action Demecarium Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:58 Last Updated: October 07, 2023 at 14:58