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Matched Description: are degradation of bradykinin, substance P, and amyloid beta-protein. Angiotensin converting enzyme … (ACE) is well known for its dual actions in converting inactive Ang I to active Ang II and degrade … bottle neck step is the production of pressor Ang II, this was targeted pharmacologically in 1970s and … of an epidemic in 2002–2003. Two isozymes of ACE are present in mammals: somatic ACE and testis ACE … . Somatic ACE possesses two catalytic domains (N- and C-domains) and a C-terminal transmembrane

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: well, reducing aldosterone and vasopressin secretion, inhibiting vasoconstriction, and allowing the … uptake of sodium and insufficient potassium excretion due to reduced aldosterone levels. Cilazapril is eliminated by the kidneys and excreted through urination. … treat hypertension and heart failure as it reduces the effects of angiotensin II which decreases … resistance and blood pressure, as angiotensin II is a potent vasoconstrictor. Angiotensin II is produced … the kidneys, blood vessels, posterior pituitary gland and excitatory amino acid transporter via

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: for the production of aldosterone which increases salt and water retention which increases blood … vasoconstrictive effects and increases blood pressure. Trandolapril is used to treat hypertension … , high blood pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … by binding to angiotensin II type 1 receptor (AT1) in blood vessels, kidneys, hypothalamus, and … volume. Less angiotensin II reduces aldosterone production allowing water retention to not increase

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Moexipril is used to treat hypertension, high … blood pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptor (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: for the production of aldosterone which increases salt and water retention which increases blood … that has powerful vasoconstrictive effects and increases blood pressure. Telmisartan used to treat … hypertension, diabetic nephropathy, and congestive heart failure. Angiotensin has many … , hypothalamus, and posterior pituitary. In blood vessels AT1 receptors cause vasoconstriction in the tunica … volume. Blocking AT1 receptors reduces aldosterone production allowing water retention to not increase

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: aldosterone which increases salt and water retention which increases blood volume. Blocking AT1 … that has powerful vasoconstrictive effects and increases blood pressure. Candesartan is used to treat … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … receptors reduces aldosterone production allowing water retention to not increase. AT1 receptors in the … effects of taking candesartan are symptomatic hypotension, abnormal renal function, and

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: , reduced secretion of avsopressin (ADH), and reduced production and secretion of aldosterone. … the treatment of hypertension and heart failure. This drug causes the blockade of the renin … -angiotensin-aldosterone system (RAAS) at the level of the AT1 receptor. Tasosartan is an antagonist of the AT1 … receptors localize in the vascular muscles and the adrenal gland. This drug thus causes dilatation

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: Tenoxicam (also named mobiflex and tilcotil) is a nonsteroidal anti-inflammatory drug (NSAID). It … can be used to reduce inflammation, swelling, stiffness, and pain that are associated with various … diseases such as tendinitis, bursitis and etc. Tenoxicam can block prostaglandin synthesis by the … action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze … the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze … the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: be used to treat prostaglandin G/H synthase related fever, swelling, pain and inflammation … and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid