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Matched Description: synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H … synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway.

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: anti-inflammatory, analgesic, and antipyretic effects in the management of osteoarthritis and for … and does not require CYP450 enzymes for metabolism. Both COX-1 and COX-2 catalyze the conversion of … arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2). PGH2 is the … precursor of a number of prostaglandins, including prostaglandin E2 (PGE2), prostaglandin I2 (PGI2) and … in the production of PGE2. PGE2 is a potent mediator of pain, inflammation and fever. The first part

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: Suprofen (also named Profenal and Maldocil) is a nonsteroidal anti-inflammatory drug (NSAID). It … can be used to relieve pain (analgesic) and reduce fever (antipyretic). Suprofen is also a type of … /H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to … prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. Since … prostaglandin synthesis can reduce the pain and inflammation (e.g. in the eyes).

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: effects by inhibiting the synthesis of prostaglandins involved in pain, fever and inflammation. COX-2 … catalyzes the conversion of arachidonic acid to prostaglandin G2 (PGE2) and PGE2 to prostaglandin H2 … (PGH2). In the COX-2 catalyzed pathway, PGH2 is the precusor of prostaglandin E2 (PGE2) and I2 … (PGI2). PGE2 induces pain, fever, erythema and edema. Celecoxib antagonizes COX-2 by binding to the … site. Similar to other COX-2 inhibitors, such as rofecoxib and valdecoxib, celecoxib appears to

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: This pathway describes the production and subsequent metabolism of arachidonic acid, an omega-6 … phosphatidylethanolamine and phosphatidylcholine) of membranes of the body’s cells, and is particularly abundant … phospholipid hydrolysis and releases the fatty acid into the intracellular medium. Three enzymes … mediate this deacylation reaction including phospholipase A2 (PLA2), phospholipase C (PLC), and … phospholipids, 2) diffusion outside the cell, and 3) metabolism. Arachidonate metabolism is carried out

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

Matched Description: receptors, nicotinic acetylcholine receptors, and sigma-1 receptors. Dextromethorphan is an agonist … of NMDA and sigma-1 receptors. It is an antagonist of neuronal acetylcholine receptors, especially … subunit 3A and prevents glutamate from binding to the NDMA receptor on the epsilon-2 subunit. This … prevents the calcium channel from opening and allowing calcium into to the post-synaptic neuron. With … reticulum of central nervous system neurons, where they regulate calcium and potassium, but the reason

Matched Compound Synonyms: Ammonia (conc 20% or greater) … Tylenol cold and flu multi-symptom … Tylenol cold and flu no drowsiness … Tylenol cold and flu multi-symptom … Tylenol cold and flu no drowsiness

Matched Description: occurs via the aquaporins. Aldosterone is released from the adrenal cortex of the kidney and acts on the … and blocks aldosterone binding. This prevents the aldosterone effects on gene transcription … Eplerenone is an oral drug used to treat conditions such as hypertension and congestive heart … duct, sodium and water reabsorption occur, along with potassium excretion. The sodium channel (ENaC … the lumen where it is excreted in urine. Water reabsorption is linked to Na+ reabsorption and

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (+)-aldosterone

Matched Description: aldosterone. This hormone increases the sodium and water reabsorption in the renal tubules. In consequence … hypertension and heart failure. This drug inhibits the vasoconstriction so it lowers the blood pressure … ) leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: II type 1 receptor (AT1 receptor) to stimulate the synthesis of aldosterone and promote renal … . This drug selectively binds to AT1 receptors as an antagonist, blocking vasoconstrictor and the … aldosterone secretion that angiotensin II provokes (RAAS). Angiotensin II usually binds to angiotensin

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: receptors in the kidney are responsible for the production of aldosterone which increases salt and … that has powerful vasoconstrictive effects and increases blood pressure. Olmesartan is indicated for … failure, and post-myocardial infarction, particularly in patients who are unable to tolerate ACE … ) in blood vessels, kidneys, hypothalamus, and posterior pituitary. In blood vessels AT1 receptors … water retention which increases blood volume. Blocking AT1 receptors reduces aldosterone production

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone