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Search for '28cortisol oh aldosterone 20 and subjected 3ametabolic' in 'all pathways' in 'all' returned 517638 results

SMP0000093

Pw000135 View Pathway
Metabolite

Diclofenac Action Pathway

Homo sapiens

  • Matched Description: to treat prostaglandin G/H synthase related fever, swelling, pain and inflammation. Diclofenac can … block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2 … . Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000113

    Pw000262 View Pathway
    Metabolite

    Oxaprozin Action Pathway

    Homo sapiens

  • Matched Description: used to relieve pain (analgesic) and reduce fever (antipyretic). Oxaprozin is also a type of … synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2 … , and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. Since … prostaglandin is the messenger molecules in the process of inflammation; hence, inhibition of prostaglandin synthesis can reduce the pain and inflammation.

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000697

    Pw000674 View Pathway
    Metabolite

    Flurbiprofen Action Pathway

    Homo sapiens

  • Matched Description: inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the … arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000702

    Pw000679 View Pathway
    Metabolite

    Nepafenac Action Pathway

    Homo sapiens

  • Matched Description: (NSAID). It can be used to treat pain and inflammation that is associated with cataract surgery … 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000704

    Pw000681 View Pathway
    Metabolite

    Tolmetin Action Pathway

    Homo sapiens

  • Matched Description: reduce pain, swelling, tenderness, and stiffness. Tolmetin can block prostaglandin synthesis by the … action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 … catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000709

    Pw000686 View Pathway
    Metabolite

    Salicylic Acid Action Pathway

    Homo sapiens

  • Matched Description: reduce pain and fever. Salicylic acid can block prostaglandin synthesis by the action of inhibition of … prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic … acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000084

    Pw000129 View Pathway
    Metabolite

    Etodolac Action Pathway

    Homo sapiens

  • Matched Description: arthritis and osteoarthritis. Most NSAIDs are non-selective prostaglandin G/H synthase (a.k.a … . cyclooxygenase or COX) inhibitors that act on both prostaglandin G/H synthase 1 and 2 (COX-1 and -2 … involved in fever, pain, swelling, inflammation, and platelet aggregation. NSAIDs antagonize COX by … entering the active site. The analgesic, antipyretic and anti-inflammatory effects of NSAIDs occur as a … -1. The first part of this figure depicts the anti-inflammatory, analgesic and antipyretic pathway

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000094

    Pw000136 View Pathway
    Metabolite

    Sulindac Action Pathway

    Homo sapiens

  • Matched Description: typically used to treat conditions associated with pain and inflammation, such as rheumatoid arthritis … , headaches or migraines, and dysmenorrhoea. Sulindac is believed to be a non-selective NSAID, meaning … that it inhibits both prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2). In this pathway … of sulindac, which then inhibits the COX-1 and COX-2 enzymes. These enzymes are normally responsible … H2 from prostaglandin G2. These prostaglandins are responsible for inflammation and fever, as well

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000114

    Pw000263 View Pathway
    Metabolite

    Nabumetone Action Pathway

    Homo sapiens

  • Matched Description: Nabumetone (also named Relafen and Relifex) is a nonsteroidal anti-inflammatory drug (NSAID). It … can be used to relieve pain (analgesic) and reduce fever (antipyretic). Nabumetone can block … prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H … synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin … the process of inflammation; hence, inhibition of prostaglandin synthesis can reduce the pain, fever and inflammation.

  • Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

  • Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

  • Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0123093

    Pw124438 View Pathway
    Metabolite

    Perindopril ACE Inhibitor Action Pathway

    Homo sapiens

  • Matched Description: production of aldosterone which increases salt and water retention which increases blood volume … vasoconstrictive effects and increases blood pressure. Perindopril is used to treat hypertension, high … blood pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … binding to angiotensin II type 1 receptor (AT1) in blood vessels, kidneys, hypothalamus, and posterior … . Less angiotensin II reduces aldosterone production allowing water retention to not increase. AT1

  • Matched Compounds: Aldosterone

  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action