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Search for '28cortisol oh aldosterone 20 and subjected 3ametabolic' in 'all pathways' in 'all' returned 200392 results

SMP0124963

Pw126469 View Pathway
Metabolite

Losartan Angiotensin blocker Action Pathway

Homo sapiens

  • Matched Description: receptors in the kidney are responsible for the production of aldosterone which increases salt and … has powerful vasoconstrictive effects and increases blood pressure. Losartan is used to treat … hypertension and diabetic nephropathy, and is used to reduce the risk of stroke as it reduces blood … (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary. In blood vessels AT1 receptors … water retention which increases blood volume. Blocking AT1 receptors reduces aldosterone production
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0123086

    Pw124431 View Pathway
    Metabolite

    Enalapril ACE Inhibitor Action Pathway

    Homo sapiens

  • Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Enalapril is used to treat hypertension, high … blood pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0123091

    Pw124436 View Pathway
    Metabolite

    Lisinopril ACE Inhibitor

    Homo sapiens

  • Matched Description: receptors in the kidney are responsible for the production of aldosterone which increases salt and … vasoconstrictive effects and increases blood pressure. Lisinopril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … vessels, kidneys, hypothalamus, and posterior pituitary. In blood vessels, AT1 receptors cause … water retention which increases blood volume. Less angiotensin II reduces aldosterone production
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0123090

    Pw124435 View Pathway
    Metabolite

    Fosinopril ACE Inhibitor Action Pathway

    Homo sapiens

  • Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Fosinopril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0122803

    Pw124137 View Pathway
    Metabolite

    Benazepril ACE inhibitor Action Pathway

    Homo sapiens

  • Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Benazepril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0124967

    Pw126474 View Pathway
    Metabolite

    Irbesartan Angiotensin blocker Action Pathway

    Homo sapiens

  • Matched Description: the kidney are responsible for the production of aldosterone which increases salt and water retention … that has powerful vasoconstrictive effects and increases blood pressure. Irbesartan is used to treat … hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure … vessels, kidneys, hypothalamus, and posterior pituitary. In blood vessels AT1 receptors cause … which increases blood volume. Blocking AT1 receptors reduces aldosterone production allowing water
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0126074

    Pw127650 View Pathway
    Metabolite

    Zofenopril Action Pathway

    Homo sapiens

  • Matched Description: of acute myocardial infaction (AMI), hypertension and mild to mmoderate hypertension. Zafenopril … has the ability to improve endothelial function and protect against ischemia. Zofenopril is a prodrug … and this leads to an increase of blood pressure. This system starts with the renin being released from … . Angiotensin II binds to AT1 and AT2, these receptors will activate many signaling cascades that … will lead to the retaining of sodium and water in the renal tubules. At the same time, these receptors
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone

  • Drug Action

    SMP0000604

    Pw000580 View Pathway
    Metabolite

    Cyclophosphamide Metabolism Pathway

    Homo sapiens

  • Matched Description: isozymes in the liver. 4-Hydroxyphosphamide is more soluble than cyclophosphamide and is the primary form … cancer cell and spontaneuosly forms aldophosphamide. This is a reversible reaction. Aldophosphamide can … decompose into acrolein and phosphoramide mustard. Phosphoramide mustard is the active alkylating … agent and forms alkyl adducts with DNA through a phosphoramide aziridinium intermediate. Alkylation … of DNA causes DNA damage and eventually cell death.
  • Matched Protein Synonyms: Cytochrome P450 MP-20
  • Matched Compound Synonyms: Magnacide h and b … [oh(oh)]

  • Drug Metabolism

    SMP0000448

    Pw000249 View Pathway
    Metabolite

    Ifosfamide Action Pathway

    Homo sapiens

  • Matched Description: liver. 4-Hydroxyifosfamide crosses the plasma membrane of the cancer cell and spontaneuosly forms … aldoifosfamide. This is a reversible reaction. Aldoifosfamide can decompose into acrolein and ifosforamide … mustard. Ifosforamide mustard is the active alkylating agent and forms alkyl adducts with DNA … through an ifosforamide aziridinium intermediate. Alkylation of DNA causes DNA damage and ultimately cell death.
  • Matched Protein Synonyms: Cytochrome P450 MP-20
  • Matched Compound Synonyms: Magnacide h and b … [oh(oh)]

  • Drug Action

    SMP0000605

    Pw000581 View Pathway
    Metabolite

    Ifosfamide Metabolism Pathway

    Homo sapiens

  • Matched Description: liver. 4-Hydroxyifosfamide crosses the plasma membrane of the cancer cell and spontaneuosly forms … aldoifosfamide. This is a reversible reaction. Aldoifosfamide can decompose into acrolein and ifosforamide … mustard. Ifosforamide mustard is the active alkylating agent and forms alkyl adducts with DNA … through an ifosforamide aziridinium intermediate. Alkylation of DNA causes DNA damage and ultimately cell death.
  • Matched Protein Synonyms: Cytochrome P450 MP-20
  • Matched Compound Synonyms: Magnacide h and b … [oh(oh)]

  • Drug Metabolism