SMP0124963
View Pathway
|
Losartan Angiotensin blocker Action Pathway
Homo sapiens
Matched Description: receptors in the kidney are responsible for the production of aldosterone which increases salt and … has powerful vasoconstrictive effects and increases blood pressure. Losartan is used to treat … hypertension and diabetic nephropathy, and is used to reduce the risk of stroke as it reduces blood … (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary.
In blood vessels AT1 receptors … water retention which increases blood volume. Blocking AT1 receptors reduces aldosterone production
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
|
SMP0123086
View Pathway
|
Enalapril ACE Inhibitor Action Pathway
Homo sapiens
Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Enalapril is used to treat hypertension, high … blood pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
|
SMP0123091
View Pathway
|
Lisinopril ACE Inhibitor
Homo sapiens
Matched Description: receptors in the kidney are responsible for the production of aldosterone which increases salt and … vasoconstrictive effects and increases blood pressure. Lisinopril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … vessels, kidneys, hypothalamus, and posterior pituitary. In blood vessels, AT1 receptors cause … water retention which increases blood volume. Less angiotensin II reduces aldosterone production
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
|
SMP0123090
View Pathway
|
Fosinopril ACE Inhibitor Action Pathway
Homo sapiens
Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Fosinopril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
|
SMP0122803
View Pathway
|
Benazepril ACE inhibitor Action Pathway
Homo sapiens
Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Benazepril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … to angiotensin II type 1 receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
|
SMP0124967
View Pathway
|
Irbesartan Angiotensin blocker Action Pathway
Homo sapiens
Matched Description: the kidney are responsible for the production of aldosterone which increases salt and water retention … that has powerful vasoconstrictive effects and increases blood pressure. Irbesartan is used to treat … hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure … vessels, kidneys, hypothalamus, and posterior pituitary.
In blood vessels AT1 receptors cause … which increases blood volume. Blocking AT1 receptors reduces aldosterone production allowing water
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
|
SMP0126074
View Pathway
|
Zofenopril Action Pathway
Homo sapiens
Matched Description: of acute myocardial infaction (AMI), hypertension and mild to mmoderate hypertension. Zafenopril … has the ability to improve endothelial function and protect against ischemia. Zofenopril is a prodrug … and this leads to an increase of blood pressure. This system starts with the renin being released from … . Angiotensin II binds to AT1 and AT2, these receptors will activate many signaling cascades that … will lead to the retaining of sodium and water in the renal tubules. At the same time, these receptors
Matched Compounds: Aldosterone
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone
|
SMP0000604
View Pathway
|
Cyclophosphamide Metabolism Pathway
Homo sapiens
Matched Description: isozymes in the liver. 4-Hydroxyphosphamide is more soluble than cyclophosphamide and is the primary form … cancer cell and spontaneuosly forms aldophosphamide. This is a reversible reaction. Aldophosphamide can … decompose into acrolein and phosphoramide mustard. Phosphoramide mustard is the active alkylating … agent and forms alkyl adducts with DNA through a phosphoramide aziridinium intermediate. Alkylation … of DNA causes DNA damage and eventually cell death.
Matched Protein Synonyms: Cytochrome P450 MP-20
Matched Compound Synonyms: Magnacide h and b … [oh(oh)]
|
SMP0000448
View Pathway
|
Ifosfamide Action Pathway
Homo sapiens
Matched Description: liver. 4-Hydroxyifosfamide crosses the plasma membrane of the cancer cell and spontaneuosly forms … aldoifosfamide. This is a reversible reaction. Aldoifosfamide can decompose into acrolein and ifosforamide … mustard. Ifosforamide mustard is the active alkylating agent and forms alkyl adducts with DNA … through an ifosforamide aziridinium intermediate. Alkylation of DNA causes DNA damage and ultimately cell death.
Matched Protein Synonyms: Cytochrome P450 MP-20
Matched Compound Synonyms: Magnacide h and b … [oh(oh)]
|
SMP0000605
View Pathway
|
Ifosfamide Metabolism Pathway
Homo sapiens
Matched Description: liver. 4-Hydroxyifosfamide crosses the plasma membrane of the cancer cell and spontaneuosly forms … aldoifosfamide. This is a reversible reaction. Aldoifosfamide can decompose into acrolein and ifosforamide … mustard. Ifosforamide mustard is the active alkylating agent and forms alkyl adducts with DNA … through an ifosforamide aziridinium intermediate. Alkylation of DNA causes DNA damage and ultimately cell death.
Matched Protein Synonyms: Cytochrome P450 MP-20
Matched Compound Synonyms: Magnacide h and b … [oh(oh)]
|