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Search for '28cortisol oh aldosterone 20 and subjected 3ametabolic' in 'all pathways' in 'all' returned 281883 results

SMP0000148 View Pathway	Metabolite Enalapril Action Pathway Homo sapiens Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin I … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Enalapril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase … bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0000163 View Pathway	Metabolite Olmesartan Action Pathway Homo sapiens Matched Description: effects of aldosterone on electrolyte and water excretion, refer to the description of the \spironolactone … prevent increasing sodium, water reabsorption and peripheral resistance (that will lead to increasing … blood pressure) via aldosterone secretion that is caused by angiotensin II. Therefore, action of … /pathways/SMP00132/pathway pathway, which describes the mechanism of direct aldosterone antagonists … . Olmesartan is an effective agent for reducing blood pressure and may be used to treat essential hypertension and heart failure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0000155 View Pathway	Metabolite Rescinnamine Action Pathway Homo sapiens Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin … enzyme (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Benazepril is a … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and … increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0127072 View Pathway	Metabolite ACE Bos taurus Matched Description: are degradation of bradykinin, substance P, and amyloid beta-protein. Angiotensin converting enzyme … (ACE) is well known for its dual actions in converting inactive Ang I to active Ang II and degrade … bottle neck step is the production of pressor Ang II, this was targeted pharmacologically in 1970s and … of an epidemic in 2002–2003. Two isozymes of ACE are present in mammals: somatic ACE and testis ACE … . Somatic ACE possesses two catalytic domains (N- and C-domains) and a C-terminal transmembrane Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Physiological
SMP0127070 View Pathway	Metabolite ACE Mus musculus Matched Description: are degradation of bradykinin, substance P, and amyloid beta-protein. Angiotensin converting enzyme … (ACE) is well known for its dual actions in converting inactive Ang I to active Ang II and degrade … bottle neck step is the production of pressor Ang II, this was targeted pharmacologically in 1970s and … of an epidemic in 2002–2003. Two isozymes of ACE are present in mammals: somatic ACE and testis ACE … . Somatic ACE possesses two catalytic domains (N- and C-domains) and a C-terminal transmembrane Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Physiological
SMP0000447 View Pathway	Metabolite Cyclophosphamide Action Pathway Homo sapiens Matched Description: isozymes in the liver. 4-Hydroxyphosphamide is more soluble than cyclophosphamide and is the primary form … cancer cell and spontaneuosly forms aldophosphamide. This is a reversible reaction. Aldophosphamide can … decompose into acrolein and phosphoramide mustard. Phosphoramide mustard is the active alkylating … agent and forms alkyl adducts with DNA through a phosphoramide aziridinium intermediate. Alkylation … of DNA causes DNA damage and eventually cell death. Matched Protein Synonyms: Cytochrome P450 MP-20 Matched Compound Synonyms: Magnacide h and b … [oh(oh)] BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0000162 View Pathway	Metabolite Losartan Action Pathway Homo sapiens Matched Description: reabsorption and peripheral resistance (that will lead to increasing blood pressure) via aldosterone secretion … decreasing blood pressure. For more information on the effects of aldosterone on electrolyte and water … the mechanism of direct aldosterone antagonists. Losartan is an effective agent for reducing blood … pressure and may be used to treat essential hypertension and heart failure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0000147 View Pathway	Metabolite Cilazapril Action Pathway Homo sapiens Matched Description: enzyme (ACE) is a component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves … angiotensin-converting enzyme (ACE) inhibitors and is used primarily to lower high blood pressure … (hypertension). This drug can also be used in the treatment of congestive heart failure and type II diabetes … concentrations and increase bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0000154 View Pathway	Metabolite Ramipril Action Pathway Homo sapiens Matched Description: component of the body's renin–angiotensin–aldosterone system (RAAS) and cleaves inactive angiotensin I into … (ACE) inhibitors and is used primarily to lower high blood pressure (hypertension). This drug can … also be used in the treatment of congestive heart failure and type II diabetes. Ramipril is a prodrug … vasodilator bradykinin. Consequently, ACE inhibitors decrease angiotensin II concentrations and increase … bradykinin concentrations resulting in blood vessel dilation and thereby lowering blood pressure. Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Drug Action
SMP0121012 View Pathway	Metabolite Kidney Function - Distal Convoluted Tubule Homo sapiens Matched Description: the release of aldosterone from the adrenal cortex and release of vasopressin from the posterior … The distal convoluted tubule of the nephron is the part of the kidney between the loop of henle and … reabsorption back into the blood circulation. In addition, sodium, chlorine, and calcium are also … reabsorbed back into the systemic circulation via their respective channels and exchangers. However … , aldosterone is a major regulator of the reabsorption of these ions as well, as it changes the Matched Compounds: Aldosterone Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone BioPAX SVG SBGN SBML PWML All files (.zip) Physiological