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Matched Description: effective. It is estimated that HADH deficiency affects less than 1 in 1,000,000 individuals.

Matched Protein Synonyms: Enoyl-CoA hydratase 1 … 17-beta-HSD 10 … 17-beta-hydroxysteroid dehydrogenase 10 … Enoyl-CoA hydratase 1 … 17-beta-HSD 10

Matched Compound Synonyms: 1-hexanoic acid … 1-pentanecarboxylic acid … 1-hexanoate … 1-pentanecarboxylate … 1-hexanoic acid

Matched Description: effective. It is estimated that HADH deficiency affects less than 1 in 1,000,000 individuals.

Matched Protein Synonyms: Enoyl-CoA hydratase 1 … 17-beta-HSD 10 … 17-beta-hydroxysteroid dehydrogenase 10 … Enoyl-CoA hydratase 1 … 17-beta-HSD 10

Matched Compound Synonyms: 1-hexanoic acid … 1-pentanecarboxylic acid … 1-hexanoate … 1-pentanecarboxylate … 3-carbamoyl-1-beta-d-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt

Matched Proteins: UDP-glucuronosyltransferase 1-10 … UDP-glucuronosyltransferase 1-4 … Dimethylaniline monooxygenase [N-oxide-forming] 1

Matched Protein Synonyms: UDPGT 1-10 … Nuclear receptor subfamily 3 group A member 1 … UDP-glucuronosyltransferase 1-D … UDPGT 1-4 … Dimethylaniline oxidase 1

Matched Compound Synonyms: (z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylamine … 1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene … 1-para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene … 1-p-b-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene … 1-p-β-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

Matched Proteins: UDP-glucuronosyltransferase 1-10 … UDP-glucuronosyltransferase 1-4 … Dimethylaniline monooxygenase [N-oxide-forming] 1

Matched Protein Synonyms: UDPGT 1-10 … Nuclear receptor subfamily 3 group A member 1 … UDP-glucuronosyltransferase 1-D … UDPGT 1-4 … Dimethylaniline oxidase 1

Matched Compound Synonyms: (z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylamine … 1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene … 1-para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene … 1-p-b-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene … 1-p-β-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

Matched Description: alpha and insulin-like growth factor 1 while increasing sex hormone binding globulin. Tamoxifen is also

Matched Proteins: UDP-glucuronosyltransferase 1-10 … Dimethylaniline monooxygenase [N-oxide-forming] 1 … ADP/ATP translocase 1 … Nuclear receptor coactivator 1

Matched Protein Synonyms: UDPGT 1-10 … Dimethylaniline oxidase 1 … FMO 1 … Fetal hepatic flavin-containing monooxygenase 1 … UDP-glucuronosyltransferase 1-J

Matched Compound Synonyms: (z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylamine … 1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene … 1-para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene … 1-p-b-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene … 1-p-β-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

Matched Description: exploit slight differences in the size of the COX-1 and -2 binding pockets to gain selectivity. COX-1 … COX-1 adds enough bulk to proclude celecoxib from binding. Celecoxib is approximately ten times more … selective for COX-2 than COX-1. Celecoxib is used mainly to treat rheumatoid arthritis and … derived from fragmentation of megakaryocytes, contain COX-1, but not COX-2. COX-1 activity in platelets … both COX-1 and COX-2. COX-2 in endothelial cells mediates the synthesis of PGI2, an effective

Matched Proteins: UDP-glucuronosyltransferase 1-10 … Prostaglandin G/H synthase 1

Matched Protein Synonyms: UDPGT 1-10 … Cytochrome P450 PB-1 … UDP-glucuronosyltransferase 1-J … UGT1*10 … UGT1-10

Matched Compound Synonyms: P-(5-p-tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide … P-(5-p-tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulphonamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide … Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-d-ribofuranosyl-3-pyridinecarboxamide

Matched Proteins: Potassium voltage-gated channel subfamily KQT member 1 … Potassium voltage-gated channel subfamily E member 1 … Voltage-dependent L-type calcium channel subunit beta-1 … Beta-1-syntrophin … Alpha-1-syntrophin

Matched Protein Synonyms: IRK-1 … Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle … Calcium channel voltage-dependent subunit beta 1 … MinK-related peptide 1 … Minimum potassium ion channel-related peptide 1

Matched Compound Synonyms: Potassium ion(1+) … Potassium(1+) ion … Potassium(1+) … Potassium ion(1+) … Potassium(1+) ion

Matched Proteins: Beta-1 adrenergic receptor … Voltage-dependent L-type calcium channel subunit beta-1 … Cytochrome b-c1 complex subunit 10 … Sodium/hydrogen exchanger 1 … Sodium/calcium exchanger 1

Matched Protein Synonyms: Minimum potassium ion channel-related peptide 1 … ERG-1 … Eag-related protein 1 … Ether-a-go-go-related gene potassium channel 1 … Ether-a-go-go-related protein 1

Matched Compound Synonyms: Potassium(1+) ion … Potassium(1+) … Potassium ion(1+) … Potassium(1+) ion … Potassium(1+)

Matched Description: by sphingosine kinases (SPHK1/2) to form sphingosine‑1‑phosphate (S1P), with S1P levels being

Matched Compounds: Sphingosine 1-phosphate … Ceramide 1-phosphate

Matched Proteins: Alkaline ceramidase 1 … Sphingosine kinase 1 … Multidrug resistance-associated protein 1 … Sphingosine 1-phosphate receptor 1 … Sphingosine 1-phosphate receptor 2

Matched Protein Synonyms: Alkaline CDase 1 … SK 1 … SPK 1 … ATP-binding cassette sub-family C member 1 … Endothelial differentiation G-protein coupled receptor 1

Matched Compound Synonyms: (2s,3r,4e)-1-(dihydrogen phosphate)2-amino-4-octadecene-1,3-diol … C18-sphingosine 1-phosphate … D-erythro-sphingosine-1-phosphate … (2s,3r,4e)-1-(dihydrogen phosphate)2-amino-4-octadecene-1,3-diol … C18-sphingosine 1-phosphate

Matched EC Numbers: 1.-.-.-; 1.14.-.-

Matched Proteins: Voltage-dependent L-type calcium channel subunit beta-1 … Beta-1-syntrophin … Alpha-1-syntrophin … Potassium voltage-gated channel subfamily KQT member 1 … Potassium voltage-gated channel subfamily E member 1

Matched Protein Synonyms: MinK-related peptide 1 … Minimum potassium ion channel-related peptide 1 … ERG-1 … Eag-related protein 1 … Ether-a-go-go-related gene potassium channel 1

Matched Compound Synonyms: Potassium(1+) ion … Potassium(1+) … Potassium ion(1+) … Potassium(1+) ion … Potassium(1+)