SMP0125749
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Primary Hyperoxaluria Type I
Homo sapiens
Matched Proteins: Alanine aminotransferase 1 … Mitochondrial pyruvate carrier 1
Matched Protein Synonyms: GPT 1 … Glutamate pyruvate transaminase 1 … Glutamic--alanine transaminase 1 … Glutamic--pyruvic transaminase 1
Matched Compound Synonyms: 1-amino-propane-1,3-dicarboxylate … 1-amino-propane-1,3-dicarboxylic acid … 1-aminopropane-1,3-dicarboxylate … 1-aminopropane-1,3-dicarboxylic acid … Hydrocarbonate(1-)
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SMP0125644
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Acute Intermittent Porphyria
Homo sapiens
Matched Description: involves undertaking a high-carbohydrate diet and, during severe attacks, a glucose 10% infusion. It is estimated that AIP affects 5.9 per 1 000 000 people.
Matched Proteins: Heme oxygenase 1
Matched Protein Synonyms: 5-aminolevulinic acid synthase 1 … Delta-ALA synthase 1 … Delta-aminolevulinate synthase 1 … HO-1
Matched Compound Synonyms: Succino-1-yl-coenzyme a … (sp-4-2)[7-ethenyl-17-formyl-12-[(4e,8e)-1-hydroxy-5,9,13-trimethyl-4,8,12-tetradecatrienyl]-3,8,13 … [sp-4-2-(e,e)]-[7-ethenyl-17-formyl-12-(1-hydroxy-5,9,13-trimethyl-4,8,12-tetradecatrienyl)-3,8,13 … 3-carbamoyl-1-beta-d-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt … 3-carbamoyl-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt
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SMP0125650
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Congenital Erythropoietic Porphyria (CEP) or Gunther Disease
Homo sapiens
Matched Description: bone marrow transplants or stem cell treatment. It is estimated that CEP affects less than 1 in 1,000,000 individuals.
Matched Proteins: Heme oxygenase 1
Matched Protein Synonyms: 5-aminolevulinic acid synthase 1 … Delta-ALA synthase 1 … Delta-aminolevulinate synthase 1 … HO-1
Matched Compound Synonyms: Succino-1-yl-coenzyme a … (sp-4-2)[7-ethenyl-17-formyl-12-[(4e,8e)-1-hydroxy-5,9,13-trimethyl-4,8,12-tetradecatrienyl]-3,8,13 … [sp-4-2-(e,e)]-[7-ethenyl-17-formyl-12-(1-hydroxy-5,9,13-trimethyl-4,8,12-tetradecatrienyl)-3,8,13 … 3-carbamoyl-1-beta-d-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt … 3-carbamoyl-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt
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SMP0126599
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Risperidone Dopamine Antagonist Action Pathway
Homo sapiens
Matched Description: antagonist of alpha-1 (α1), alpha-2 (α2), and histamine (H1) receptors. Blockade of these receptors
Matched Proteins: Voltage-dependent L-type calcium channel subunit beta-1 … Solute carrier family 22 member 1
Matched Protein Synonyms: Calcium channel, L type, alpha-1 polypeptide isoform 4 … Calcium channel voltage-dependent subunit beta 1 … Organic cation transporter 1 … Organic cation transporter 1
Matched Compound Synonyms: L-erythro-1-(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-1,2-propanediol
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SMP0127686
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Gi Serotonergic Smooth Muscle Relaxation
Mus musculus
Matched Proteins: Inositol 1,4,5-trisphosphate receptor type 1 … Adenylate cyclase type 1 … Voltage-dependent L-type calcium channel subunit beta-1 … Guanine nucleotide-binding protein G(i) subunit alpha-1 … Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Matched Protein Synonyms: Tissue-specific extinguisher 1 … Tissue-specific extinguisher 1 … Calcium channel voltage-dependent subunit beta 1 … Tissue-specific extinguisher 1
Matched Compound Synonyms: Potassium ion(1+) … Potassium(1+) ion … Potassium(1+) … Potassium ion(1+) … Potassium(1+) ion
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SMP0127693
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Gs Serotonergic Smooth Muscle Contraction
Mus musculus
Matched Proteins: Inositol 1,4,5-trisphosphate receptor type 1 … Adenylate cyclase type 1 … Voltage-dependent L-type calcium channel subunit beta-1
Matched Protein Synonyms: Tissue-specific extinguisher 1 … Tissue-specific extinguisher 1 … Calcium channel voltage-dependent subunit beta 1 … Tissue-specific extinguisher 1
Matched Compound Synonyms: Potassium ion(1+) … Potassium(1+) ion … Potassium(1+) … Potassium ion(1+) … Potassium(1+) ion
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SMP0125902
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Tenofovir Disoproxil Action Pathway
Homo sapiens
Matched Description: Hepatitis B infection and used to manage HIV-1 infection. This drug prevents viral DNA chain … elongation through inhibition of enzymes necessary for host cell infection viral replication in HIV-1 and … diphosphate inhibits HIV-1 reverse transcriptase and the Hepatitis B polymerase by direct binding in
Matched Proteins: Adenylate kinase isoenzyme 1
Matched Protein Synonyms: AK 1 … ATP-AMP transphosphorylase 1 … Organic anion transporter 1 … Renal organic anion transporter 1
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SMP0125914
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Cabotegravir Action Pathway
Homo sapiens
Matched Description: Cabotegravir is an HIV-1 integrase inhibitor used for treatment and pre-exposure prophylaxis of HIV … -1 infection. It is prescribed with the non-nucleoside reverse transcriptase inhibitor, rilpivirine
Matched Proteins: Importin subunit beta-1
Matched Protein Synonyms: Organic anion transporter 1 … Renal organic anion transporter 1 … RAG cohort protein 1 … Karyopherin subunit beta-1
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SMP0126331
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Methsuximide Action Pathway
Homo sapiens
Matched Proteins: Glutamate decarboxylase 1 … Adenylate cyclase type 1 … Gamma-aminobutyric acid type B receptor subunit 1
Matched Protein Synonyms: ATP pyrophosphate-lyase 1 … Adenylyl cyclase 1 … Solute carrier family 32 member 1 … Calcium channel, L type, alpha-1 polypeptide isoform 4
Matched Compound Synonyms: 1-amino-propane-1,3-dicarboxylate … 1-amino-propane-1,3-dicarboxylic acid … 1-aminopropane-1,3-dicarboxylate … 1-aminopropane-1,3-dicarboxylic acid … Chloride(1-)
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SMP0126353
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Atomoxetine Action Pathway (New)
Homo sapiens
Matched Proteins: Voltage-dependent L-type calcium channel subunit beta-1 … Beta-1 adrenergic receptor
Matched Protein Synonyms: Calcium channel, L type, alpha-1 polypeptide isoform 4 … Calcium channel voltage-dependent subunit beta 1 … Beta-1 adrenoceptor … Beta-1 adrenoreceptor
Matched Compound Synonyms: (r)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol … 4-[(1r)-2-amino-1-hydroxyethyl]-1,2-benzenediol … 4-(2-amino-1-hydroxyethyl)-1,2-benzenediol … L-2-amino-1-(3,4-dihydroxyphenyl)ethanol … 1-dehydroascorbate
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