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Matched Description: formulation. Haloperidol is extensively metabolised in the liver with only about 1% of the administered

Matched Compounds: 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP+)

Matched Proteins: Carbonyl reductase [NADPH] 1 … UDP-glucuronosyltransferase 1-9 … Solute carrier family 22 member 1

Matched Protein Synonyms: NADPH-dependent carbonyl reductase 1 … UDP-glucuronosyltransferase 1-I … UDPGT 1-9 … Organic cation transporter 1

Matched Compound Synonyms: 1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine … 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide … Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-d-ribofuranosyl-3-pyridinecarboxamide

Matched Description: by Glutaminase liver isoform, mitochondrial into glutamic acid. Glutamic acid is carboxylated into 1 … -Pyrroline-5-carboxylic acid by the enzyme Delta-1-pyrroline-5-carboxylate synthase. 1-Pyrroline-5

Matched Compounds: 1-Pyrroline-5-carboxylic acid

Matched Proteins: Delta-1-pyrroline-5-carboxylate synthase … Mitochondrial ornithine transporter 1

Matched Protein Synonyms: ASCT-1 … Alanine/serine/cysteine/threonine transporter 1 … Solute carrier family 1 member 4 … Mitochondrial aspartate glutamate carrier 1

Matched Compound Synonyms: 1-amino-propane-1,3-dicarboxylic acid … 1-aminopropane-1,3-dicarboxylate … 1-aminopropane-1,3-dicarboxylic acid … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

Matched Description: transported into the cell via the long-chain fatty acid transport protein 1 (FATP1). Once inside the cell it … facilitated by the long-chain fatty-acid CoA ligase 1 protein, which adds a CoA moiety to appropriate … , acetyl-CoA in the cytosol can be catalyzed by acetyl-CoA carboxylase 1 to form malonyl-CoA, which … inhibits the action of carnitine O-palmitoyltransferase 1, thereby preventing 4-methylhexanoylcarnitine

Matched Proteins: Long-chain-fatty-acid--CoA ligase 1 … Carnitine O-palmitoyltransferase 1, liver isoform … Acetyl-CoA carboxylase 1 … Long-chain fatty acid transport protein 1

Matched Protein Synonyms: Acyl-CoA synthetase 1 … LACS 1 … Long-chain acyl-CoA synthetase 1 … Palmitoyl-CoA ligase 1

Matched Compound Synonyms: 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine

Matched Description: transported into the cell via the long-chain fatty acid transport protein 1 (FATP1). Once inside the cell … facilitated by the long-chain fatty-acid CoA ligase 1 protein, which adds a CoA moiety to … . Finally, acetyl-CoA in the cytosol can be catalyzed by acetyl-CoA carboxylase 1 to form malonyl-CoA … , which inhibits the action of carnitine O-palmitoyltransferase 1, thereby preventing 6

Matched Proteins: Long-chain-fatty-acid--CoA ligase 1 … Carnitine O-palmitoyltransferase 1, liver isoform … Acetyl-CoA carboxylase 1 … Long-chain fatty acid transport protein 1

Matched Protein Synonyms: Acyl-CoA synthetase 1 … LACS 1 … Long-chain acyl-CoA synthetase 1 … Palmitoyl-CoA ligase 1

Matched Compound Synonyms: 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine

Matched Description: transported into the cell via the long-chain fatty acid transport protein 1 (FATP1). Once inside the cell it … facilitated by the long-chain fatty-acid CoA ligase 1 protein, which adds a CoA moiety to appropriate … , acetyl-CoA in the cytosol can be catalyzed by acetyl-CoA carboxylase 1 to form malonyl-CoA, which … inhibits the action of carnitine O-palmitoyltransferase 1, thereby preventing 6-methyloctanoylcarnitine

Matched Proteins: Long-chain-fatty-acid--CoA ligase 1 … Carnitine O-palmitoyltransferase 1, liver isoform … Acetyl-CoA carboxylase 1 … Long-chain fatty acid transport protein 1

Matched Protein Synonyms: Acyl-CoA synthetase 1 … LACS 1 … Long-chain acyl-CoA synthetase 1 … Palmitoyl-CoA ligase 1

Matched Compound Synonyms: 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine

Matched Description: transported into the cell via the long-chain fatty acid transport protein 1 (FATP1). Once inside the cell it … facilitated by the long-chain fatty-acid CoA ligase 1 protein, which adds a CoA moiety to appropriate … , acetyl-CoA in the cytosol can be catalyzed by acetyl-CoA carboxylase 1 to form malonyl-CoA, which … inhibits the action of carnitine O-palmitoyltransferase 1, thereby preventing 7-methyloctanoylcarnitine

Matched Proteins: Long-chain-fatty-acid--CoA ligase 1 … Carnitine O-palmitoyltransferase 1, liver isoform … Acetyl-CoA carboxylase 1 … Long-chain fatty acid transport protein 1

Matched Protein Synonyms: Acyl-CoA synthetase 1 … LACS 1 … Long-chain acyl-CoA synthetase 1 … Palmitoyl-CoA ligase 1

Matched Compound Synonyms: 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine

Matched Description: transported into the cell via the long-chain fatty acid transport protein 1 (FATP1). Once inside the cell … facilitated by the long-chain fatty-acid CoA ligase 1 protein, which adds a CoA moiety to … . Finally, acetyl-CoA in the cytosol can be catalyzed by acetyl-CoA carboxylase 1 to form malonyl-CoA … , which inhibits the action of carnitine O-palmitoyltransferase 1, thereby preventing 7

Matched Proteins: Long-chain-fatty-acid--CoA ligase 1 … Carnitine O-palmitoyltransferase 1, liver isoform … Acetyl-CoA carboxylase 1 … Long-chain fatty acid transport protein 1

Matched Protein Synonyms: Acyl-CoA synthetase 1 … LACS 1 … Long-chain acyl-CoA synthetase 1 … Palmitoyl-CoA ligase 1

Matched Compound Synonyms: 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine

Matched Description: first transported into the cell via the long-chain fatty acid transport protein 1 (FATP1). Once inside … . This reaction is facilitated by the long-chain fatty-acid CoA ligase 1 protein, which adds a CoA … acetyl-CoA carboxylase 1 to form malonyl-CoA, which inhibits the action of carnitine O … -palmitoyltransferase 1, thereby preventing (3S)-3-hydroxydecanoylcarnitine from forming and thereby preventing it from being transported into the mitochondria.

Matched Proteins: Long-chain-fatty-acid--CoA ligase 1 … Carnitine O-palmitoyltransferase 1, liver isoform … Acetyl-CoA carboxylase 1 … Long-chain fatty acid transport protein 1

Matched Protein Synonyms: Acyl-CoA synthetase 1 … LACS 1 … Long-chain acyl-CoA synthetase 1 … Palmitoyl-CoA ligase 1

Matched Compound Synonyms: 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine

Matched Description: cell via the long-chain fatty acid transport protein 1 (FATP1). Once inside the cell it undergoes a … long-chain fatty-acid CoA ligase 1 protein, which adds a CoA moiety to appropriate acyl groups. Many … carboxylase 1 to form malonyl-CoA, which inhibits the action of carnitine O-palmitoyltransferase 1

Matched Proteins: Long-chain-fatty-acid--CoA ligase 1 … Carnitine O-palmitoyltransferase 1, liver isoform … Acetyl-CoA carboxylase 1 … Long-chain fatty acid transport protein 1

Matched Protein Synonyms: Acyl-CoA synthetase 1 … LACS 1 … Long-chain acyl-CoA synthetase 1 … Palmitoyl-CoA ligase 1

Matched Compound Synonyms: 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine

Matched Description: cell via the long-chain fatty acid transport protein 1 (FATP1). Once inside the cell it undergoes a … long-chain fatty-acid CoA ligase 1 protein, which adds a CoA moiety to appropriate acyl groups. Many … carboxylase 1 to form malonyl-CoA, which inhibits the action of carnitine O-palmitoyltransferase 1

Matched Proteins: Long-chain-fatty-acid--CoA ligase 1 … Carnitine O-palmitoyltransferase 1, liver isoform … Acetyl-CoA carboxylase 1 … Long-chain fatty acid transport protein 1

Matched Protein Synonyms: Acyl-CoA synthetase 1 … LACS 1 … Long-chain acyl-CoA synthetase 1 … Palmitoyl-CoA ligase 1

Matched Compound Synonyms: 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium … 3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt … 1-carnitine