SMP0125919
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Phenoxymethylpenicillin Action Pathway
Clostridium perfringens (strain 13 / Type A)
Matched Description: Phenoxymethylpenicillin (Penicillin V) is a penicillin antibiotic used to prevent and treat mild to … moderately severe infections in the respiratory tract, skin, and soft tissues. It is indicated for … , with the use of bacteriological studies (including sensitivity tests) and clinical response … respiratory tract, scarlet fever, and mild erysipelas caused by Streptococcus without bacteremia 2 … of the skin and soft tissues caused by penicillin G-sensitive Staphylococcus 4) mild to moderately
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SMP0125827
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Naftifine Action Pathway
Homo sapiens
Matched Description: Naftifine is an antifungal agent used to treat infections of the Tinea, Trichophyton, and … Epidermophyton species. It is used as a topical treatment of tinea pedis, tinea cruris, and tinea corporis … caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and … Epidermophyton floccosum. Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine … , Epidermophyton floccosum, and Microsporum canis, Microsporum audouini, and Microsporum gypseum; and
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SMP0126377
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Trospium Action Pathway
Homo sapiens
Matched Description: , Combivent, and Ipravent. It is commonly administered through inhalation which allows producing a local … system in the airways and hence, inhibit their function. The function of the parasympathetic system … in the airway is to generate bronchial secretions and constriction and hence, the inhibition of this … action can lead to bronchodilation and fewer secretions. At the cellular level, the diameter of the … contract and producing a narrow airway. Thus administration of ipratropium stops the activity of
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SMP0126763
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Quinupristin Action Pathway
Homo sapiens
Matched Description: Enterococcus faecium bacteremia and skin infections. It inhibits the late phase of protein synthesis by … binding to the 50S ribosomal subunit preventing elongation of the forming polypeptide and causing the
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SMP0127027
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Gi Serotonergic Vasoconstriction
Bos taurus
Matched Description: dairy cow diseases. Serotonin is a potent regulator of both calcium homeostasis and energy … homeostasis during lactation in both rodent and dairy cow models. G proteins, also known as guanine nucleotide … -binding proteins, are a family of proteins that act as molecular switches inside cells, and are … activity is regulated by factors that control their ability to bind to and hydrolyze guanosine … triphosphate (GTP) to guanosine diphosphate (GDP). When they are bound to GTP, they are 'on', and, when they
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SMP0127689
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Insulin
Drosophila melanogaster
Matched Description: metabolism, growth, reproduction and lifespan. Drosophila insulin-like peptides (DIPLs) bind to insulin … receptors (InR), leading to receptor activation and autophosphorylation. Activated Drosophila InR (dInR … as an intracellular second messenger and activates a cascade of protein kinases, including dPDK1 and … dAkt1, resulting in phosphorylation of the transcription factor dFOXO and inhibition of its … dInR and CHICO leads to a reduction of PI3K activity. Activity of PI3K is also reduced through
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SMP0125086
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Prazosin Action Pathway
Homo sapiens
Matched Description:
Prazosin is an alpha-blocker that causes a decrease in total peripheral resistance and is used to … blood pressure in humans. Two types of alpha receptors, alpha 1 and alpha 2, both play a role in … between a nerve fiber and target tissue). In this case, the target tissue is the vascular smooth … phospholipase C. Phospholipase C converts phosphatidylinositol 4,5-bisphosphate to diacylglycerol and … to calcium influx into the cytosol from the sarcoplasmic reticulum. Calcium binds to calmodulin and
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SMP0126814
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Dextropropoxyphene Opioid Agonist Action Pathway
Homo sapiens
Matched Description: Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to … , kappa, and delta opioid receptors on presynaptic neuron membranes, stimulating the exchange of GTP … for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the … , dopamine, acetylcholine, and noradrenaline is inhibited. Opioids close N-type voltage-operated calcium … channels and open calcium-dependent inwardly rectifying potassium channels. This results in
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SMP0126725
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Metrifonate Action Pathway
Homo sapiens
Matched Description: acetylcholine, allowing the neurotransmitter to interact with the receptors that help aid memory and … cognition in patients with dementia and alzheimer's disease.
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SMP0130606
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Zoledronate D,L-Lysine Monohydrate Drug Metabolism
Homo sapiens
Matched Description: determined by current research and biotransformer analysis. Zoledronate D,L-Lysine Monohydrate passes through … the liver and is then excreted from the body mainly through the kidney.
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