SMP0002239
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Operon: dnaAN-recF
Escherichia coli
Matched Description: and replication. The operon can be activated by the binding of HTH-type transcriptional regulator … the number of DnaA-ATP complexes bound. When cells have grown, DnaA is produced and can accumulate … operon, recF, encodes the DNA replication and repair protein RecF, a protein required for DNA replication, as well as recombination.
Matched Proteins: DNA replication and repair protein RecF
Gene Regulatory
Cellular Response
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SMP0120936
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Stat3 Signaling Pathway
Bos taurus
Matched Description: by some of the cells in the immune system, and are vital to signalling pathways in the body of … find tyrosine-kinases that are associated to the receptor, including JAK and Src when it is time for … phosphorylation cascade. This means that STAT3 is now activated, and its compounds disconnect from the … receptor site, and relocate to the nucleus. Once there, the compounds bind to DNA response elements, and … take part in many processes against target genes, such as apoptosis and cell proliferation, regulating their transcription.
Matched Proteins: Signal transducer and activator of transcription 3
Gene Regulatory
Cytokine Signaling
Cellular Response
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SMP0120944
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g-Secretase Mediated ErbB4 Signalling Pathway
Bos taurus
Matched Description: and intracellular kinase domains and the manner in which such protein induce the ligands … .
Experiments revealed that erbB4 has is readily findable in heart, spleen, breast, muscle, pituitary, kidney, parathyroid, brain, and testis.
Matched Proteins: Disintegrin and metalloproteinase domain-containing protein 10
Kinase Signaling
Cellular Response
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SMP0373159
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Fatty Acid Oxidation
Escherichia coli (strain B / BL21-DE3)
Matched Description: fatty acids into acetyl-CoA under both anaerobic and aerobic conditions. Enzymes in this pathway can … process short and long chain fatty acids, both starting the conversion of acyl-CoA to enoyl-CoA. The … acetyl-CoA and NADH. Fatty acids are an important source of energy because they can be reduced due
Matched Proteins: AMP-dependent synthetase and ligase
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SMP0373546
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Fatty Acid Oxidation
Brachyspira pilosicoli B2904
Matched Description: fatty acids into acetyl-CoA under both anaerobic and aerobic conditions. Enzymes in this pathway can … process short and long chain fatty acids, both starting the conversion of acyl-CoA to enoyl-CoA. The … acetyl-CoA and NADH. Fatty acids are an important source of energy because they can be reduced due
Matched Proteins: AMP-dependent synthetase and ligase
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SMP0373789
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Fatty Acid Oxidation (Myristate)
Bacteroides xylanisolvens XB1A
Matched Description: because they are anhydrous and can be reduced. Fatty acids are good sources of energy as they yield … under anaerobic and aerobic conditions. Enzymes of this pathway can process short and long chain
Matched Proteins: Predicted dehydrogenases and related proteins
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SMP0000659
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Timolol Action Pathway
Homo sapiens
Matched Description: relieves symptoms such as tachycardia, vascular headaches, hypertension, angina and tremors. Timolol, much … kinase catalytic subunit alpha activates outage-dependent L-type calcium channel subunit alpha 1C and 2 … transporting calcium into the myocyte from the the sarcoplasmic reticulum. The calcium and calmodulin then … muscle, results in a muscle contraction. Then in the cell membrane we have PIP2(16:0/20:3(8Z,11Z … ,14Z)) catalyzing into DG(14:0/14:1(9Z)/0:0) and inositol 1,4,5-triphosphate with the help of the
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SMP0385919
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Proline Metabolism
Serratia marcescens subsp. marcescens Db11
Matched Description: , an NADP and a L-glutamic gamma-semialdehyde. L-glutamic gamma-semialdehyde is dehydrated … spontaneously, resulting in a release of water,hydrogen ion and 1-Pyrroline-5-carboxylic acid. The latter … -proline. L-proline works as a repressor of the pyrroline-5-carboxylate reductase enzyme and glutamate 5 … -kinase. Three genetic loci, proA, proB and proC control the biosynthesis of L-proline in E … the antagonistic nucleophilic and aqueous environment found in the cell. Finally, NADPH-dependent
Matched Proteins: Glutamate and aspartate transporter subunit
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SMP0445832
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Secondary Metabolites: Glyoxylate Cycle
Megasphaera elsdenii DSM 20460
Matched Description: The glyoxylate cycle starts with the interaction of Acetyl-Coa with a water molecule and Oxalacetic … acid interact through a Citrate synthase resulting in a release of a coenzyme a and citric acid … molecule and cis-Aconitic acid. The cis-Aconitic acid is then hydrated in an reversible reaction through … reversible reaction through isocitrate lyase resulting in the release of a succinic acid and a glyoxylic … acid. The glyoxylic acid then reacts in a reversible reaction with an acetyl-coa, and a water
Matched Proteins: Lactoylglutathione lyase and related lyases
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SMP0125290
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Gemfibrozil Action Pathway
Homo sapiens
Matched Description: (particularly in type IV and V hyperlipidemia).
Gemfibrozil is available in 600 mg oral tablets. The … medication 30 minutes before morning and evening meals.
Gemfibrozil acts in the nucleus where is … and enzymes involved lipolysis, fatty acid transport and biosynthesis, vLDL and HDL synthesis. Fatty … upregulating apolipoprotein A1 (APOA1) and apolipoproteins A2 (APOA2), which forms part of HDL. HDL … is considered good cholesterol. VLDL and LDL are considered bad cholesterol. These levels are
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