SMP0121128
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Pancreas Function - Delta Cell
Homo sapiens
Matched Description: Pancreatic delta cells produce somatostatin which functions to inhibit glucagon, insulin, and … itself. Somatostatin is stored in granules in the delta cell and is released in response to an increase … in blood sugar, calcium, and blood amino acids during absorption of a meal. In the process of
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SMP0126520
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Caffeine Cardiac Contraction Action Pathway
Homo sapiens
Matched Description: Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to … increase alertness. The cardiovascular effects are extensive and can help with headaches, migraines … other chemicals present in it. This means that much of the research is not well understood, and
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SMP0125968
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Remdesivir Action Pathway
Homo sapiens
Matched Description: emergency use Authorization on May 1, 2020, for use in adults and children with suspected or … -CoV, SARS-CoV-2, and MERS-CoV.
Severe acute respiratory syndrome conronavirus 2 (SARS-CoV-2) is the … causative agent of COVID-19, and is a respiratory disease that is capable of progressing to viral … pneumonia and acute respiratory distress syndrome (ARDS). COVID-19 can be fatal. Like other RNA … much higher selectivity of mammalian DNA and RNA polymerases for ATP over remdesivir triphosphate
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SMP0126606
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Bendamustine Action Pathway
Homo sapiens
Matched Description: treat chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has … bases. It is bifunctional because it can trigger intra- and inter-strand crosslinks. This prevents … the replication and the transcription of the DNA. The general mechanism of action is unknown but those
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SMP0126917
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Gi Adrenergic Smooth Muscle Contraction
Rattus norvegicus
Matched Description: targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced … by the body, but also many medications like beta blockers, beta-2 (β2) agonists and alpha-2 (α2 … ) agonists, which are used to treat high blood pressure and asthma, for example. The α2, on the other … heterotrimeric G protein, composed of three subunits: a Gα protein such as Giα, and a complex of two … tightly linked proteins called Gβ and Gγ in a Gβγ complex. When not stimulated by a receptor, Gα is
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SMP0349085
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Methylphosphonate Degradation I
Escherichia coli O157:H7 str. Sakai
Matched Description: release of a hydrogen ion, a pyrophosphate and a alpha-Dribose-1-methylphosphonate 5-phosphate. The … and a 5-phospho-alpha-D-ribose 1,2-cyclic phosphate. This compound in turn gets degraded by a water … driven 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase resulting in the release of a hydrogen ion and a alpha-D-ribose 1,5-biphosphate.
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SMP0349090
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Methylphosphonate Degradation I
Escherichia coli str. K-12 substr. DH10B
Matched Description: release of a hydrogen ion, a pyrophosphate and a alpha-Dribose-1-methylphosphonate 5-phosphate. The … and a 5-phospho-alpha-D-ribose 1,2-cyclic phosphate. This compound in turn gets degraded by a water … driven 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase resulting in the release of a hydrogen ion and a alpha-D-ribose 1,5-biphosphate.
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SMP0349102
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Methylphosphonate Degradation I
Escherichia coli O111:H- str. 11128
Matched Description: release of a hydrogen ion, a pyrophosphate and a alpha-Dribose-1-methylphosphonate 5-phosphate. The … and a 5-phospho-alpha-D-ribose 1,2-cyclic phosphate. This compound in turn gets degraded by a water … driven 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase resulting in the release of a hydrogen ion and a alpha-D-ribose 1,5-biphosphate.
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SMP0349097
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Methylphosphonate Degradation I
Escherichia coli ED1a
Matched Description: release of a hydrogen ion, a pyrophosphate and a alpha-Dribose-1-methylphosphonate 5-phosphate. The … and a 5-phospho-alpha-D-ribose 1,2-cyclic phosphate. This compound in turn gets degraded by a water … driven 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase resulting in the release of a hydrogen ion and a alpha-D-ribose 1,5-biphosphate.
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SMP0333235
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Methylphosphonate Degradation I
Desulfovibrio piger ATCC 29098
Matched Description: release of a hydrogen ion, a pyrophosphate and a alpha-Dribose-1-methylphosphonate 5-phosphate. The … and a 5-phospho-alpha-D-ribose 1,2-cyclic phosphate. This compound in turn gets degraded by a water … driven 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase resulting in the release of a hydrogen ion and a alpha-D-ribose 1,5-biphosphate.
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