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Matched Description: step in gastric acid production. In this pathway, esomeprazole is taken orally and is oxidized in … -dependent and last much longer than similar drugs that bind to the protein non-covalently. This is … pantoprazole. Esomeprazole is used to manage gastroesophageal reflux disease, to prevent stomach ulcers, and

Matched Description: final step in gastric acid production. In this pathway, lansoprazole is taken orally and is oxidized in … dose-dependent and last much longer than similar drugs that bind to the protein non-covalently. This is … pantoprazole. Lansoprazole is used to manage gastroesophageal reflux disease, to prevent stomach ulcers, and

Matched Description: arsenite, arsenate and antimonite in the cell. The operon can be repressed by the arsenical resistance … , antimony and bismuth, its repression of the operon is removed, and the genes can be properly

Matched Description: inborn error of metabolism (IEM) and autosomal recessive disorder caused by either a homozygous or … generalized amino aciduria and marked galactosuria. Treatment usually includes galactose restricted … with galactokinase deficiency and classic galactosemia, patients with galactose epimerase deficiency

Matched Description: a tertiary complex between the DNA and the topoisomerase I enzyme causing double strand breaks. It … function variant of UGT1A1 which can lead to increased metabolism of irinotecan and leads to irinotecan … and headaches. Irinotecan is administered usually intravenously as a solution.

Matched Description: Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG). Because of the inhibition, IP3 doesn't … activate the release of calcium from the sarcoplasmic reticulum, and DAG doesn't activate the … in the cytosol, and it, therefore, cannot bind to calmodulin.Calcium bound calmodulin is required for

Matched Description: Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG). Because of the inhibition, IP3 doesn't … activate the release of calcium from the sarcoplasmic reticulum, and DAG doesn't activate the … in the cytosol, and it, therefore, cannot bind to calmodulin.Calcium bound calmodulin is required for

Matched Description: targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced … by the body, but also many medications like beta blockers, beta-2 (β2) agonists and alpha-2 (α2 … ) agonists, which are used to treat high blood pressure and asthma, for example. The α2, on the other … heterotrimeric G protein, composed of three subunits: a Gα protein such as Giα, and a complex of two … tightly linked proteins called Gβ and Gγ in a Gβγ complex. When not stimulated by a receptor, Gα is

Matched Description: , postherpetic neuralgia, and partial-onset seizures. Gabapentin acts at the nerve terminals of … neurotransmitters like glutamate contribute to neuropathic pain and seizures. The role of gabapentin is to … influx is prevented and the release of glutamate neurotransmitter does not occur.

Matched Description: 5-HT1B and 5-HT1D receptors. It is structurally distinct from, but pharmacologically related to … channel activity and has no significant affinity for benzodiazepine binding sites. Frovatriptan is … believed to act on extracerebral, intracranial arteries and to inhibit excessive dilation of these