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Matched Description: like ABCB1 and works by forming a complex with FKBP12 with inhibits calcineurin with leads to … reduced T cell signal transduction and IL-2 transcription. IL-2 is an important mediator for T-cell … activation, differentiation and migration which is through mTOR signalling. Lower IL-2 production and … also inhibits the transcription for genes encoding IL-3,4,5, GM-SCF, and TNF as well which are also … transplant for liver, kidney, heart, small bowel, pancreas, lung, trachea, skin, cornea and limb transplant.

Matched Description: fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, and bone infections … bacterial membranes causing displacement of divalent cations and increasing membrane permeability … bacterial 30S ribosome and binds to it, halting protein synthesis. It binds to the site where the … normal base pairing of codon and anti-codon takes place as well as adding amino acids to the growing … polypeptide chain, with this blocked it leads to termination of the chain and production of non

Matched Description: Iodipamide is a contrast agent used in cholangiography and cholecystography. Organic iodine … (concentration and volume) of the iodinated contrast agent in the path of the x-rays. Iodipamide's primary … excretion through the hepato-biliary system and concentration in bile allows visualization of the … gallbladder and biliary ducts. iodipamide is carried to the liver where it is rapidly secreted. The … of the hepatic and common bile ducts, even in cholecystectomized patients. The biliary ducts are

Matched Description: species and Aspergillus species in severely immunocompromised patients. For prophylaxis of invasive … Aspergillus and Candida infections in patients, 13 years of age and older, who are at high risk of … of the triazolone side chain. These modifications enhance the potency and spectrum of activity of … cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells … . This leads to cell lysis which causes it to collapse and die.

Matched Description: agent. It is used as a treatment of breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non … -Hodgkins lymphoma, mycosis fungoides, histiocytosis and Kaposi's sarcoma. Its antitumor activity is … proteins; cellular tumor antigen p53 and cyclin dependent kinase inhibitor p21. The latter protein … on BAK and BAX to enact conformational changes, creating pores in the mitochondrial membrane that … essential cellular proteins. In this way, p53 and p21 work alongside each other to promote apoptosis and terminate unhealthy cells.

Matched Description: Newer dopamine receptor agonists such as quinagolide and Cabergoline are shown to effectively … patients who are intolerant or resistant to Bromocriptine. Quinagolide exists as a racemate and its … the hydrochloride salt form and is marketed as oral tablets. Quinagolide is a non-ergot-derived … effect via selectively targeting D2 receptors as an agonist. It potently suppresses both basal and … adenosine monophosphate and inhibited prolactin secretion. It also binds to D1 receptors but with low affinity and little clinical relevance.

Matched Description: with a long onset and duration of action. It was withdrawn from the European Union due to its high … system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids … neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited … . Opioids close N-type voltage-operated calcium channels and open calcium-dependent inwardly … rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. Morphine

Matched Description: On the World Health Organization's List of Essential Medicines and a prototypical drug of its class … , propranolol is a non-cardioselective beta blocker and it is typically synthesized as a racemic … it passes through hepatic portal circulation, and enters the bloodstream to act on peripheral cells … , and pheochromocytoma. It can be found under the brand names Hemangeol, Hemangiol, Inderal, and … muscle contraction (vasoconstriction in this case). Some side effects of using propranolol may include dizziness, tiredness, and difficulties sleeping.

Matched Description: Carboprost tromethamine is a medication primarily used in obstetrics and gynecology for two … , typically between the 13th and 20th weeks of gestation. This is indicated when other methods of … of abortion and provide hemostasis in postpartum hemorrhage. However, it can also lead to side … effects such as vomiting, diarrhea, transient temperature increases, and, in some cases … procedure carried out under specific circumstances and should only be administered by trained healthcare

Matched Description: 30S ribosome subunit formation, as well as transcription, translation and tRNA formation. The operon … can be activated by DNA-binding protein Fis, which binds to the promoter region and activates … form a complex with six subunits of the ArgR protein, forming an arginine repressor that binds to and … inhibits the transcription of the operon. This operon also has multiple terminators, and if they are … transcription termination/antitermination protein NusA, which is involved in the termination and