SMP0120905
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Ubiquitin–Proteasome Pathway
Mus musculus
Matched Description: effects in many other pathways and processes. This pathway uses 2 distinct steps. The first step is that … . This pathway is important for DNA repair, regulating the amount of proteins, and the creation of antigen-peptide.
Matched Proteins: STIP1 homology and U box-containing protein 1
Transport/Degradation
Cellular Response
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SMP0407945
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Lipopolysaccharide Biosynthesis
Halococcus morrhuae DSM 1307
Matched Description: either the fructose 6-phosphate produced by glycolysis and pyruvate dehydrogenase or obtained from the … and a glucosamine 6-phosphate. The latter compound is isomerized through a phosphoglucosamine mutase … through a bifunctional protein glmU resulting in a Coenzyme A, hydrogen ion and N-acetyl-glucosamine 1 … -phosphate. The latter interacts with UTP and hydrogen ion through the bifunctional protein glmU … resulting in a pyrophosphate and a UDP-N-acetylglucosamine. UDP-N-acetylglucosamine iinteracts with (3R)-3
Matched Proteins: Xanthine and Co dehydrogenase maturation factor
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SMP0422563
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Oxidative Phosphorylation
Odoribacter laneus YIT 12061
Matched Description: acid, resulting in a fumaric acid and ubiquinol.
Ubiquinone interacts with succinic acid through a … cofactors, ferroheme b, 2FE-2S, FAD, and 3Fe-4S iron-sulfur cluster.
Then 2 ubiquinol interact with … oxygen and 4 hydrogen ion through a cytochrome bd-I terminal oxidase resulting in a 4 hydrogen ion … transferred into the periplasmic space, 2 water returned into the cytoplasm and 2 ubiquinone, which … and 4 hydrogen ion through a cytochrome bd-II terminal oxidase resulting in a 4 hydrogen ion
Matched Proteins: Succinate dehydrogenase and fumarate reductase iron-sulfur protein
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SMP0107992
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Histamine H1 Receptor Activation
Mus musculus
Matched Description: -like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3, and H4 … . Histamine receptor H1 belongs to the family of G-protein-coupled receptors (GPCRs), and it is … expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous … system. It is linked to an intracellular G-protein (Gαq) that activates phospholipase C and the … release and expression of the NF-κB immune response transcription factor. H1-antihistamines inactivate
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SMP0126102
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Pirbuterol Action Pathway
Homo sapiens
Matched Description: is used as a bronchodilator for the treatment of asthma and relief from bronchospasm. The result of … taking this drug is relaxation of the bronchial smooth muscles causing bronchodilaton and increased … airflow. Once pirbuterol is administered and it binds to the beta-2 adrenergic receptor, the G … protein signalling cascade begins. The alpha and beta/gamma subunits of the G protein separate and GDP … and inhibits MLCK through decreased calcium levels causing muscle relaxation. PKA can phosphorylate
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SMP0126088
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Arformoterol Action Pathway
Homo sapiens
Matched Description: and chronic bronchitis. It accomplishes this by upon inhalation of the drug by relaxing smooth … muscles in the airways to improve breathing. It can be found under the brand name Brovana, and it has a … 2 fold greater potency than racemic formoterol. Once arformoterol is administered and it binds to … the beta-2 adrenergic receptor, the G protein signalling cascade begins. The alpha and beta/gamma … subunits of the G protein separate and GDP is replaced with GTP on the alpha subunit. This alpha subunit
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SMP0174954
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Dexchlorpheniramine maleate H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: Dexchlorpheniramine maleate is a first generation H1-antihistamine used to treat allergic and … vasomotor rhinitis, allergic conjunctivitis, and mild urticaria and angioedema. H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and … vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax
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SMP0126086
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Formoterol Action Pathway
Homo sapiens
Matched Description: Formoterol is a long acting beta-2 adrenergic receptor agonist that is used as a bronchodilator and … to manage asthma and COPD. It can be used as well for prophylaxis against exercise induced … bronchospasm. This drug is inhaled and can be recognized under the brand names Bevespi, Breyna, Duaklir … , Foradil, Oxeze, Zenhale, and Symbicort. Formoterol both has a rapid onset and a long duration of action … muscles and opening of the airways through its binding to the beta-2 adrenergic receptors which causes G
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SMP0124744
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Betaine Drug Metabolism
Homo sapiens
Matched Description: Betaine is obtained from foods such as wheat, shellfish, spinach, and beets. In the intestine … ). The toxicity of betaine is due to the formation of TMA and its metabolism to Trimethylamine N-oxide … microbe, then TMA then enters the bloodstream and is transported to the liver where dimethylaniline … the heart, kidney and vascular system by contributing to cardiovascular disease, atherosclerosis, endothelial dysfunction and kidney disease.
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SMP0126638
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Anistreplase Action Pathway (new)
Homo sapiens
Matched Description: such as myocardial infarction and pulmonary emboli. It is administered intravenously and travels … fibrin matrix of the blood clot breaking it down into degradation products. Due to its anticoagulant and … antiplatelet activity, avoid herbs and supplements with similar activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.
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