SMP0126186
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Bisoprolol Action Pathway (New)
Homo sapiens
Matched Description: through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In … bronchial and vascular smooth muscle, bisoprolol can compete with epinephrine for beta adrenergic … synthesis, which in turn activates PKA production, which then activates SRC and nitric oxide synthase, its … inhibition causes the inhibition of cAMP, PKA, SRC and nitric oxide synthase signaling. Following … , the inhibition of SRC in essence causes the activation of Caspase 3 and Caspase 9. This Caspase
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SMP0126926
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Gadodiamide Metabolism
Homo sapiens
Matched Description: procedures to assist in the visualization of blood vessels. It is intravenously injected and is … commonly marketed under the trade name Omniscan and used in MRI to visualize lesions with abnormal … vascularity in the brain (intracranial lesions), spine, and associated tissues. There is no detectable biotransformation or decomposition of gadodiamide.
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SMP0126931
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Ofloxacin Action Pathway
Haemophilus influenzae
Matched Description: the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.
Ofloxacin … inhibits DNA gyrase (topoisomerase II) and topoisomerase IV. These proteins prevent supercoiling in … bacterial DNA. The inhibition of DNA gyrase (topoisomerase II) and topoisomerase IV causes
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SMP0175253
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Cefoperazone Action Pathway
Escherichia coli
Matched Description: infections in various locations, including the respiratory tract, abdomen, skin, and female genital … tracts. Cefoperazone exhibits a bactericidal mode of action. It works by binding to and inhibiting … synthesis by interfering with the lengthening and strengthening of the peptidoglycan portion of the cell wall, thereby inhibiting cell wall synthesis.
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SMP0174941
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Terfenadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and … vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax … those muscles.
H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and … rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T-cells to
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SMP0174967
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Chlorpromazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on … vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … , and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response, in
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SMP0174955
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GSK-1004723 H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 … vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and
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SMP0174953
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Dimetotiazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on … vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … , and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response, in
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SMP0174972
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Cariprazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 … vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and
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SMP0174902
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Diphenhydramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on … vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … , and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response, in
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