SMP0000097
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Ethacrynic Acid Action Pathway
Homo sapiens
Matched Description: Etacrynic acid (also known as ethacrynic acid and Edecrin) is a loop diuretic that can inhibit … water reabsorption by binding and inhibiting solute carrier family 12 member 1 (also known as sodium … environment in lumen than interstitium, and result in prevention of water reabsorption due to diminished osmotic gradient in nephron.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000090
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Bendroflumethiazide Action Pathway
Homo sapiens
Matched Description: transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000110
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Indapamide Action Pathway
Homo sapiens
Matched Description: treat hypertension and decompensated heart failure. Indapamide can inhibit sodium-chloride symporter … member 3) can translocate chloride and sodium from lumen to epithelial cell. Sodium-potassium ATPase
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000100
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Hydrochlorothiazide Action Pathway
Homo sapiens
Matched Description: chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000723
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Cystinuria
Homo sapiens
Matched Description: in the kidneys. The mutations cause this process to be compromised and allows the amino acids to … build up and have a high concentration in urine. This causes crystals to form and become stones as they … , develop infection and disrupt the passing of urine through the urinary tract if the stones create a blockage there.
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000115
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Furosemide Action Pathway
Homo sapiens
Matched Description: Furosemide (also named Lasix) is a medication that can be used for high blood pressure and fluid … build-up which caused by heart failure, liver scarring, or kidney disease. Furosemide can bind and … from lumen to basolateral interstitium, which lead to more hypertonic in lumen and less hypertonic in
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000078
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Chlorothiazide Action Pathway
Homo sapiens
Matched Description: that count for 5% of total amount. Solute carrier family 12 member 3 transports chloride and sodium … from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to
Matched Compounds: Aldosterone
Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000575
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11-beta-Hydroxylase Deficiency (CYP11B1)
Homo sapiens
Matched Description: recessive disorder and caused by a defective 11-beta-hydroxylase. 11-beta-hydroxylase catalyzes the … conversion of cortexolone into cortisol which is useful for maintaining blood sugar levels and … endoplasmic reticulum (ER). Symptoms of the disorder include abnormality of hair growth rate and
Matched Compounds: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al … Aldosterone … 3a-Hydroxy-5b-pregnane-20-one
Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (3a,5b,11b)-3,11,21-trihydroxy-pregnan-20-one
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SMP0000718
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3-beta-Hydroxysteroid Dehydrogenase Deficiency
Homo sapiens
Matched Description: metabolism (IEM) and autosomal recessive disorder of the steroidogenesis pathway. It is caused by an defect … produced, cortisol levels in the cell are lowered, and as cortisol is used in the production of other … of cortisol produced in the adrenal glands. Symptoms include abnormal genitalia for both males and
Matched Compounds: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al … Aldosterone … 3a-Hydroxy-5b-pregnane-20-one
Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (3a,5b,11b)-3,11,21-trihydroxy-pregnan-20-one
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SMP0125804
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3-beta-Hydroxysteroid Dehydrogenase Deficiency
Homo sapiens
Matched Description: metabolism (IEM) and autosomal recessive disorder of the steroidogenesis pathway. It is caused by an defect … produced, cortisol levels in the cell are lowered, and as cortisol is used in the production of other … of cortisol produced in the adrenal glands. Symptoms include abnormal genitalia for both males and
Matched Compounds: 3a,11b,21-Trihydroxy-20-oxo-5b-pregnan-18-al … Aldosterone … 3a-Hydroxy-5b-pregnane-20-one
Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (3a,5b,11b)-3,11,21-trihydroxy-pregnan-20-one
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