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Matched Description: transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: treat hypertension and decompensated heart failure. Indapamide can inhibit sodium-chloride symporter … member 3) can translocate chloride and sodium from lumen to epithelial cell. Sodium-potassium ATPase

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: hypertonic and a decreased osmotic gradient thereby reducing the water reabsorption. In the nephron, the … think ascending limb reabsorbs 25% of sodium and is a good target for diuretics.

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: Amiloride is a diuretic that inhibits the sodium channels in the late distal convoluted tubule and … reabsorption results in increased osmolarity in the lumen and decreased osmolarity in the interstitium … electrochemical gradient and therefore, inhibits potassium excretion. Amiloride causes an increase in … sodium excretion and a decrease in potassium secretion. The drug is typically prescribed to patients with depleted potassium.

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: molecule that belongs to a class of drugs called thiazides. Thiazides and thiazide-like drugs are diuretics … the nephron and therefore increase fluid loss which decreases extracellular fluid (ECF), plasma … volume, and ultimately blood pressure. In the case of quinethazone, it inhibits the sodium-chloride … long-term mechanism of action isn’t as well-characterized and it is thought that other processes … beyond regulating plasma and ECF volumes are involved as these two volumes return to baseline within 4-6 weeks of first use of thiazides.

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: used to manage hypertension and edema. It acts by blocking epithelial sodium channels in the late … in the nephron. This primarily contributes to an increase in sodium excretion and consequentially … , fluid excretion which decreases blood volume and blood pressure. Potassium secretion is indirectly … action for potassium-sparing drugs -- and has the potential to induce hyperkalemia which can potentially lead to severe heart arrhythmias.

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: called thiazides. Thiazides and thiazide-like drugs are diuretics commonly employed to control … hypertension. Trichloromethiazide acts by inhibiting chloride and potentially sodium reabsorption in the … increased fluid loss which ultimately reduces blood volume and pressure. Trichlormethiazide also acts … to inhibit sodium uptake and increase potassium excretion which also serves to increase fluid loss … . The long-term antihypertensive effects of thiazides and thiazide-like drugs such as

Matched Compounds: Aldosterone

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)