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Search for '肿瘤综合治疗电子杂志 胃癌治疗进展 2024第10卷第1期' in 'all pathways' in 'all' returned 485011 results

SMP0000116

Pw000277 View Pathway
Metabolite

Valdecoxib Action Pathway

Homo sapiens

  • Matched Description: and does not require CYP450 enzymes for metabolism. Both COX-1 and COX-2 catalyze the conversion of … from fragmentation from megakaryocytes, contain COX-1, but not COX-2. COX-1 activity in platelets is … -1 and COX-2. COX-2 in endothelial cells mediates the synthesis of PGI2, an effective platelet … aggregation inhibitor and vasodilator, while COX-1 mediates vasoconstriction and stimulates platelet … of proteins. Phosphorylation of inositol 1,4,5-trisphosphate receptor type 1 on the endoplasmic

  • Matched Proteins: Leukotriene-B(4) omega-hydroxylase 1 … Gamma-glutamyltranspeptidase 1 … Glutathione peroxidase 1 … Aldo-keto reductase family 1 member C3 … Carbonyl reductase [NADPH] 1

  • Matched Protein Synonyms: GGT 1 … Gamma-glutamyltransferase 1 … Gamma-glutamyltranspeptidase 1 heavy chain … Gamma-glutamyltranspeptidase 1 light chain … Glutathione hydrolase 1

  • Matched Compound Synonyms: 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

  • Matched EC Numbers: 1.-.-.-; 1.1.1.357; 1.1.1.112; 1.1.1.188; 1.1.1.239; 1.1.1.64; 1.3.1.20

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0063595

    Pw064570 View Pathway
    Metabolite

    Arachidonic Acid Metabolism

    Mus musculus

  • Matched Description: phospholipase D (PLD). Once released, free arachidonate has three possible fates: 1) reincorporation into

  • Matched Proteins: Glutathione hydrolase 1 proenzyme … Glutathione peroxidase 1 … Carbonyl reductase [NADPH] 1 … Prostaglandin G/H synthase 1

  • Matched Compound Synonyms: 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Metabolic

    SMP0087315

    Pw088334 View Pathway
    Metabolite

    Arachidonic Acid Metabolism

    Rattus norvegicus

  • Matched Description: phospholipase D (PLD). Once released, free arachidonate has three possible fates: 1) reincorporation into

  • Matched Proteins: Glutathione hydrolase 1 proenzyme … Glutathione peroxidase 1 … Aldo-keto reductase family 1 member C18 … Microsomal glutathione S-transferase 1 … Carbonyl reductase [NADPH] 1

  • Matched Compound Synonyms: 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Metabolic

    SMP0000353

    Pw000118 View Pathway
    Metabolite

    Leukotriene C4 Synthesis Deficiency

    Homo sapiens

  • Matched Proteins: Leukotriene-B(4) omega-hydroxylase 1 … Gamma-glutamyltranspeptidase 1 … Glutathione peroxidase 1 … Aldo-keto reductase family 1 member C3 … Carbonyl reductase [NADPH] 1

  • Matched Protein Synonyms: GGT 1 … Gamma-glutamyltransferase 1 … Gamma-glutamyltranspeptidase 1 heavy chain … Gamma-glutamyltranspeptidase 1 light chain … Glutathione hydrolase 1

  • Matched Compound Synonyms: 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

  • Matched EC Numbers: 1.-.-.-; 1.1.1.357; 1.1.1.112; 1.1.1.188; 1.1.1.239; 1.1.1.64; 1.3.1.20

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Disease

    SMP0000077

    Pw000125 View Pathway
    Metabolite

    Piroxicam Action Pathway

    Homo sapiens

  • Matched Description: can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2 … . Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also

  • Matched Proteins: Prostaglandin G/H synthase 1 … Leukotriene-B(4) omega-hydroxylase 1 … Gamma-glutamyltranspeptidase 1 … Glutathione peroxidase 1 … Aldo-keto reductase family 1 member C3

  • Matched Protein Synonyms: Cyclooxygenase-1 … PGH synthase 1 … PGHS-1 … PHS 1 … Prostaglandin H2 synthase 1

  • Matched Compound Synonyms: 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

  • Matched EC Numbers: 1.-.-.-; 1.1.1.357; 1.1.1.112; 1.1.1.188; 1.1.1.239; 1.1.1.64; 1.3.1.20

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000087

    Pw000132 View Pathway
    Metabolite

    Rofecoxib Action Pathway

    Homo sapiens

  • Matched Description: to exploit slight differences in the size of the COX-1 and -2 binding pockets to gain selectivity … . COX-1 contains isoleucines at positions 434 and 523, whereas COX-2 has slightly smaller valines … chains in COX-1 adds enough bulk to proclude rofecoxib from binding. Rofecoxib is 100 times more … selective for COX-2 than COX-1. The analgesic, antipyretic and anti-inflammatory effects of rofecoxib … COX-1, but not COX-2. COX-1 activity in platelets is required for thromboxane A2 (TxA2)-mediated

  • Matched Proteins: Leukotriene-B(4) omega-hydroxylase 1 … Gamma-glutamyltranspeptidase 1 … Glutathione peroxidase 1 … Aldo-keto reductase family 1 member C3 … Carbonyl reductase [NADPH] 1

  • Matched Protein Synonyms: GGT 1 … Gamma-glutamyltransferase 1 … Gamma-glutamyltranspeptidase 1 heavy chain … Gamma-glutamyltranspeptidase 1 light chain … Glutathione hydrolase 1

  • Matched Compound Synonyms: 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

  • Matched EC Numbers: 1.-.-.-; 1.1.1.357; 1.1.1.112; 1.1.1.188; 1.1.1.239; 1.1.1.64; 1.3.1.20

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000120

    Pw000264 View Pathway
    Metabolite

    Naproxen Action Pathway

    Homo sapiens

  • Matched Description: inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the

  • Matched Proteins: Prostaglandin G/H synthase 1 … Leukotriene-B(4) omega-hydroxylase 1 … Gamma-glutamyltranspeptidase 1 … Glutathione peroxidase 1 … Aldo-keto reductase family 1 member C3

  • Matched Protein Synonyms: Cyclooxygenase-1 … PGH synthase 1 … PGHS-1 … PHS 1 … Prostaglandin H2 synthase 1

  • Matched Compound Synonyms: 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

  • Matched EC Numbers: 1.-.-.-; 1.1.1.357; 1.1.1.112; 1.1.1.188; 1.1.1.239; 1.1.1.64; 1.3.1.20

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000106

    Pw000276 View Pathway
    Metabolite

    Meloxicam Action Pathway

    Homo sapiens

  • Matched Description: . cyclooxygenase or COX) inhibitors that act on both prostaglandin G/H synthase 1 and 2 (COX-1 and … derived from fragmentation from megakaryocytes, contain COX-1, but not COX-2. COX-1 activity in … both COX-1 and COX-2. COX-2 in endothelial cells mediates the synthesis of PGI2, an effective … platelet aggregation inhibitor and vasodilator, while COX-1 mediates vasoconstriction and stimulates … number of proteins. Phosphorylation of inositol 1,4,5-trisphosphate receptor type 1 on the

  • Matched Proteins: Leukotriene-B(4) omega-hydroxylase 1 … Gamma-glutamyltranspeptidase 1 … Glutathione peroxidase 1 … Aldo-keto reductase family 1 member C3 … Carbonyl reductase [NADPH] 1

  • Matched Protein Synonyms: GGT 1 … Gamma-glutamyltransferase 1 … Gamma-glutamyltranspeptidase 1 heavy chain … Gamma-glutamyltranspeptidase 1 light chain … Glutathione hydrolase 1

  • Matched Compound Synonyms: 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

  • Matched EC Numbers: 1.-.-.-; 1.1.1.357; 1.1.1.112; 1.1.1.188; 1.1.1.239; 1.1.1.64; 1.3.1.20

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000693

    Pw000670 View Pathway
    Metabolite

    Antrafenine Action Pathway

    Homo sapiens

  • Matched Description: by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2

  • Matched Proteins: Prostaglandin G/H synthase 1 … Leukotriene-B(4) omega-hydroxylase 1 … Gamma-glutamyltranspeptidase 1 … Glutathione peroxidase 1 … Aldo-keto reductase family 1 member C3

  • Matched Protein Synonyms: Cyclooxygenase-1 … PGH synthase 1 … PGHS-1 … PHS 1 … Prostaglandin H2 synthase 1

  • Matched Compound Synonyms: 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

  • Matched EC Numbers: 1.-.-.-; 1.1.1.357; 1.1.1.112; 1.1.1.188; 1.1.1.239; 1.1.1.64; 1.3.1.20

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action

    SMP0000698

    Pw000675 View Pathway
    Metabolite

    Magnesium Salicylate Action Pathway

    Homo sapiens

  • Matched Description: can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2 … . Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also

  • Matched Proteins: Prostaglandin G/H synthase 1 … Leukotriene-B(4) omega-hydroxylase 1 … Gamma-glutamyltranspeptidase 1 … Glutathione peroxidase 1 … Aldo-keto reductase family 1 member C3

  • Matched Protein Synonyms: Cyclooxygenase-1 … PGH synthase 1 … PGHS-1 … PHS 1 … Prostaglandin H2 synthase 1

  • Matched Compound Synonyms: 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-d-ribofuranosylnicotinamide … 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide

  • Matched EC Numbers: 1.-.-.-; 1.1.1.357; 1.1.1.112; 1.1.1.188; 1.1.1.239; 1.1.1.64; 1.3.1.20

    • BioPAX SVG SBGN SBML PWML All files (.zip)

    Drug Action