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Matched Description: either the fructose 6-phosphate produced by glycolysis and pyruvate dehydrogenase or obtained from the … and a glucosamine 6-phosphate. The latter compound is isomerized through a phosphoglucosamine mutase … through a bifunctional protein glmU resulting in a Coenzyme A, hydrogen ion and N-acetyl-glucosamine 1 … -phosphate. The latter interacts with UTP and hydrogen ion through the bifunctional protein glmU … resulting in a pyrophosphate and a UDP-N-acetylglucosamine. UDP-N-acetylglucosamine iinteracts with (3R)-3

Matched Proteins: ABC-type multidrug transport system, ATPase and permease components

Matched Description: Diltiazem is a calcium channel blocker used to treat hypertension and to manage chronic stable … angina. It can be found under the names Cardizem, Cartia, Matzim, Taztia, Tiadylt, and Tiazac. Diltiazem … is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 … cardiac and vascular smooth muscle during depolarization. Compared to dihydropyridine drugs, such as … nifedipine, that preferentially act on vascular smooth muscle and verapamil that directly acts on

Matched Description: Indacaterol is an inhaled beta-2 adrenergic agonist that is both rapid onset and long acting. The … purpose of this drug is to relax bronchial smooth muscle to help treat COPD, asthma, and chronic … bronchitis by opening the airways. It can be found under the brand names Hirobriz, Onbrez, and Ultibro … bronchial smooth muscles causing bronchodilator and increased airflow. Once Indacaterol is administered … and it binds to and activates the beta-2 adrenergic receptor, the G protein signalling cascade

Matched Description: ). The HIV virus binds and penetrates host cell. Viral RNA is transcribed into viral DNA via reverse … transcriptase. Viral DNA enters the host nucleus and is integrated into the host DNA via integrase … capsid and matrix protein to form the outer protein shell, and Pol encodes for the reverse transcriptase … and integrase protein to synthesize and incorporate its genome into host cells. HIV-1 protease … cleaves the Gag-pol polyprotein into 66 molecular species, including HIV-1 protease, integrase, and

Matched Description: Nicardipine is a calcium channel blocker used for the short-term treatment of hypertension and … with marked vasodilator action. It has antihypertensive properties and is effective in the treatment … of angina and coronary spasms without showing cardiodepressant effects. It has also been used in … the treatment of asthma and enhances the action of specific antineoplastic agents. Nicardipine, a … inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina

Matched Description: , magnesium deficiency, and tetany. It can be found under the brand names Concept Ob, Suprep Bowel Prep … Kit, and Tis-U-sol. A small colorless crystal used as an anticonvulsant, a cathartic, and an … electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of … action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases … the frequency and force of contractions. Magnesium is the second most plentiful cation of the

Matched Description: Cetuximab is an epidermal growth factor receptor inhibitor used to treat tumors and certain cancers … being specific for human EGFR. It blocks other ligands of the EGFR from binding and activating … numerous signalling cascades to promote cell growth, proliferation, and differentiation. The main cascades … proliferation and differentiation and the PI3K/AKT1 signalling cascade which also affects proliferation but … membrane and goes on to phosphorylate and regulate the activities of several transcription factors

Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on … vessels, and in smooth muscles of lungs and intestines to relax those muscles. Allergies causes … blood vessel dilation which causes swelling (edema) and fluid leakage. Cinnarizine inhibits the H1 … ) and Diacylglycerol (DAG). Because of the inhibition, IP3 doesn't activate the release of calcium

Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on … vessels, and in smooth muscles of lungs and intestines to relax those muscles. Allergies causes … blood vessel dilation which causes swelling (edema) and fluid leakage. Cinnarizine inhibits the H1 … ) and Diacylglycerol (DAG). Because of the inhibition, IP3 doesn't activate the release of calcium

Matched Description: activity against a wide spectrum of pathogens and used for the treatment of bacterial infections … and prevent bacterial growth. Josamycin enters through the bacterial cell membrane through a … transporter and binds to the bacterial ribosome. The bacterial ribosome consists of two subunits: the 50s … and the 30s subunit. Josamycin binds to the 50s subunit and prevents translocation of the tRNA along … the A, P and E sites of the ribosome. Translocation of amino acids from the acceptor site (A site) to