SMP0174950
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Chlorpheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act … blood vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … , and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response, in
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SMP0174957
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Ziprasidone H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on … vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … , and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response, in
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SMP0174969
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Zuclopenthixol H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act … blood vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1 … -antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to … conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response
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SMP0123030
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Quinethazone Action Pathway
Homo sapiens
Matched Description: convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and … , which pumps Na+ into the interstitium-blood area and K+ into the epithelial cell; the Na+/Ca2 … + exchanger, which pumps Na+ into the cell and Ca2+ into the interstitium-blood; and the chloride … transports K+ out of the epithelial cell, and a Na+/Cl- cotransporter which transports Na+ and Cl- into … from the blood into the epithelial cells. In the cell, it has access to the Na+/Cl- transporter and
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SMP0124517
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Bumetanide Diruretic Action Pathway
Homo sapiens
Matched Description: associated with congestive heart failure, hepatic and renal disease including the nephrotic syndrome … basolateral membrane of the ascending loop of henle contains the Na+/K+ ATPase, Cl- channel and K+/Cl- co … -transporter which are essential for the function for ion and water reabsorption. The Na+/K+ ATPase pumps … Na+ from the cell into the peritubular fluid and K+ from the peritubular fluid into the cell. The K … +/Cl- co-transporter moves K+ and Cl- from the cell into the peritubular fluid and the Cl- channel
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SMP0126849
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Moroctocog Alfa Action Pathway
Homo sapiens
Matched Description: Moroctocog alfa also known as Refacto AF and Xyntha, is a B-domain deleted recombinant factor VIII … deficient in those with hemophilia, this allows coagulation factor IX and X to be activated and facilitate the clotting cascade.
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SMP0126995
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Zolmitriptan Mechanism of Action Action Pathway
Homo sapiens
Matched Description: , with enhanced specificity for the 5-HT1B and 5-HT1D receptor subtypes. It is through the downstream … adverse cardiovascular effects such as myocardial ischemia/infarction, arrhythmias, cerebral and … subarachnoid hemorrhage, stroke, gastrointestinal ischemia, and peripheral vasospastic reactions.
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SMP0000295
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Lymecycline Action Pathway
Homo sapiens
Matched Description: . Lymecycline is lipophilic and can diffuse across bacterial cell membranes or travel through membrane … subunit and prevents aminoacyl tRNA from binding to the A site of the ribosome-RNA complex; aminoacyl … tRNA binding inhibition likely occurs through steric hindrance. This results in inhibition of bacterial protein synthesis and hence cell growth.
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SMP0002533
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Phosphatidylcholine Biosynthesis PC(10:0/16:0)
Saccharomyces cerevisiae
Matched Description: -methyltransferase resulting in the release of hydrogen ion and S-adenosylhomocysteine an a PE-NMe. The … -methyltransferase resulting in the release of hydrogen ion, s-adenosylhomocysteine and PE-NMe2. The PE-NMe2 reacts … resuilting in the release of hydrogen ion, s-adenosylhomocysteine and PC
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SMP0002538
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Phosphatidylcholine Biosynthesis PC(12:0/16:0)
Saccharomyces cerevisiae
Matched Description: -methyltransferase resulting in the release of hydrogen ion and S-adenosylhomocysteine an a PE-NMe. The … -methyltransferase resulting in the release of hydrogen ion, s-adenosylhomocysteine and PE-NMe2. The PE-NMe2 reacts … resuilting in the release of hydrogen ion, s-adenosylhomocysteine and PC
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