SMP0473714
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Menaquinol Biosythesis
Escherichia coli O103:H2 str. 12009
Matched Description: isochorismate synthase. Isochorismate then interacts with 2-oxoglutare and a hydrogen ion through a 2 … carbon dioxide and a 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate. The latter … resulting in the release of a pyruvate and a (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate … water molecule and a 2-succinylbenzoate. This compound then interacts with a coenzyme A and an ATP … through a o-succinylbenzoate CoA ligase resulting in the release of a diphosphate, a AMP and a
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SMP0123059
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Carbamazepine Sodium Channel Analgesic Action Pathway
Homo sapiens
Matched Description: Carbamazepine is an oral drug used as an antiepileptic, analgesic and mood stabilizer drug. It is … used to treat conditions including simple and complex partial seizures, generalized tonic-clonic … resting potential. The action potentials created travel down the axon of the neuron and at the nerve … vesicles containing neurotransmitters like glutamate to fuse with the membrane and expel the … neurotransmitter into the synapse. Glutamate binds to AMPA and NMDA receptor on the post synaptic neurons
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SMP0123150
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Trichlormethiazide Action Pathway (New)
Homo sapiens
Matched Description: heart failure) and hypertension. In the distal convoluted tubule (DCT), the regulation of ions such … as sodium, potassium, calcium, chloride, and magnesium occurs. In epithelial cells of the DCT, the … and K+ into the epithelial cell; the Na+/Ca2+ exchanger, which pumps Na+ into the cell and Ca2 … + into the interstitium-blood; and the chloride transporter which transports chloride into the … the epithelial cell, a potassium channel that transports K+ out of the epithelial cell, and a Na
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SMP0124520
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Bupranolol Action Pathway
Homo sapiens
Matched Description: orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to … act on cardiomyocytes. In bronchial and vascular smooth muscle, bupranolol can compete with … typically activates cAMP synthesis, which in turn activates PKA production, which then activates SRC and … nitric oxide synthase, its inhibition causes the inhibition of cAMP, PKA, SRC and nitric oxide … end of this reaction chain, the inhibition of SRC in essence causes the activation of Caspase 3 and
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SMP0120738
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Metachromatic Leukodystrophy (MLD)
Rattus norvegicus
Matched Description: , neural and non neural tissues like kidney and gallbladder.
MLD like many conditions comes in a slew of … different shapes and sizes. The most common these is known as the late infantile form. This form … affects children after their first year of age and manifests itself with children having difficulty … , muscle weakness, rigidity and wasting, convulsions, and dementia, just to name a few. In extreme … cases a comatose state may arise in affected children and without treatment, the majority of those
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SMP0124684
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Levodopa Pahway
Homo sapiens
Matched Description: results in the disruption of the nigrostriatal pathway and thus, decreasing the striatal dopamine … is to increase dopamine in the striatum to increase and improve motor output.
Levodopa by various … transporter-2. When an action potential is generated and reaches the nerve terminal where dopamine is … receptor, which activates the Gi signaling cascade and inhibits the neurons leaving the striatum and … the external globus pallidus to inhibit the subthalamic nucleus, internal globus pallidus and the
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SMP0063610
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DNA Replication Fork
Mus musculus
Matched Description: DNA is composed of two long and complementary strands, with a backbone on the outside and … DNA strands and break the hydrogen bonds which hold them together. The result is that two long … different processes. Because DNA is replicated in the 5' to 3' direction, and because both DNA strands in … the replication fork are negative mirror images of each other, and because the replication fork is … : the leading and the lagging strand.
These strands are so named by the way in which DNA
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SMP0473704
View Pathway
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Menaquinol Biosythesis
Escherichia coli O157:H7 str. TW14359
Matched Description: isochorismate synthase. Isochorismate then interacts with 2-oxoglutare and a hydrogen ion through a 2 … carbon dioxide and a 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate. The latter … resulting in the release of a pyruvate and a (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate … water molecule and a 2-succinylbenzoate. This compound then interacts with a coenzyme A and an ATP … through a o-succinylbenzoate CoA ligase resulting in the release of a diphosphate, a AMP and a
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SMP0473634
View Pathway
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Menaquinol Biosythesis
Escherichia coli O127:H6 str. E2348/69
Matched Description: isochorismate synthase. Isochorismate then interacts with 2-oxoglutare and a hydrogen ion through a 2 … carbon dioxide and a 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate. The latter … resulting in the release of a pyruvate and a (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate … water molecule and a 2-succinylbenzoate. This compound then interacts with a coenzyme A and an ATP … through a o-succinylbenzoate CoA ligase resulting in the release of a diphosphate, a AMP and a
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SMP0473054
View Pathway
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Menaquinol Biosythesis
Bacteroides plebeius
Matched Description: isochorismate synthase. Isochorismate then interacts with 2-oxoglutare and a hydrogen ion through a 2 … carbon dioxide and a 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate. The latter … resulting in the release of a pyruvate and a (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate … water molecule and a 2-succinylbenzoate. This compound then interacts with a coenzyme A and an ATP … through a o-succinylbenzoate CoA ligase resulting in the release of a diphosphate, a AMP and a
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