SMP0062883
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Deptropine H1-Antihistamine Action
Homo sapiens
Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to … treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. Reducing the … activity of the NF-κB immune response transcription factor through the phospholipase C and the … phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression of pro … -inflammatory cytokines, cell adhesion molecules, and chemotactic factors. Furthermore, lowering
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SMP0058936
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Hydroxyzine H1-Antihistamine Action
Homo sapiens
Matched Description: agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory … process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria … and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the … expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors … histamine release. First-generation antihistamines readily cross the blood-brain barrier and cause
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SMP0058964
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Buclizine H1-Antihistamine Action
Homo sapiens
Matched Description: agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process … in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria … . Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and … the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the … expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. Furthermore
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SMP0059058
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Cetirizine H1-Antihistamine Action
Homo sapiens
Matched Description: agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory … process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria … and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the … expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors … histamine release. First-generation antihistamines readily cross the blood-brain barrier and cause
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SMP0126580
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Thiothixene Dopamine Antagonist Action Pathway
Homo sapiens
Matched Description: and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic … -receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as … pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation … , antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors … and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism
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SMP0126432
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Betrixaban Action Pathway
Homo sapiens
Matched Description: Betrixaban is an anticoagulant that targets and inhibits factor Xa in order to prevent venous … thromboembolism. Due to its interaction with factor Xa, the coagulant factor is no longer free and unable … to form the prothrombinase complex. Betrixaban is administered orally and rapidly absorbed, if … eliminated via the gastrointestinal system, feces and urine. Some possible adverse effects are … bleeding, hypersensitivity and minimal hepatotoxicity. The anticoagulant does interact with food, this
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SMP0000557
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Sucrase-Isomaltase Deficiency
Homo sapiens
Matched Description: Congenital sucrase-isomaltase deficiency is a rare inborn error of metabolism (IEM) and autosomal … . Sucrase-isomaltase catalyzes the breakdown of sucrose, maltose and larger carbohydrates. Sucrose … and maltose are disaccharides, and are broken down into simple sugars during digestion. Sucrose is … broken down into glucose and fructose, while maltose is broken down into two glucose molecules. This … disorder is characterized by stomach cramps, bloating, excess gas production, and diarrhea after
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SMP0175075
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Cyproheptadine H1-Antihistamine Immune Response Action Pathway
Homo sapiens
Matched Description: with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory … process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and … phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and … the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors … further histamine release. First-generation antihistamines readily cross the blood-brain barrier and
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SMP0057583
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Mepyramine H1-Antihistamine Action
Homo sapiens
Matched Description: interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … , and urticaria. Reducing the activity of the NF-κB immune response transcription factor through the … phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen … presentation and the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic … barrier and cause sedation and other adverse central nervous system (CNS) effects (e.g. nervousness
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SMP0057585
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Chloropyramine H1-Antihistamine Action
Homo sapiens
Matched Description: with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and … phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation … and the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors … further histamine release. First-generation antihistamines readily cross the blood-brain barrier and
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