SMP0384057
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Taurine Metabolism
Escherichia coli ED1a
Matched Description: and oxygen resulting in the release of succinic acid, sulfite, aminoacetaldehyde, and carbon dioxide.
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SMP0381684
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Taurine Metabolism
Kingella oralis ATCC 51147
Matched Description: and oxygen resulting in the release of succinic acid, sulfite, aminoacetaldehyde, and carbon dioxide.
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SMP0659862
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Iron-sulphur cluster system (isc operon activation)
Pseudomonas aeruginosa
Matched Description: The isc operon is involved in Fe-S clusters synthesis and their incorporation into apoproteins … . Unlike the suf system, the isc system has a wider range of Fe-S proteins and specificity. The operon is … S from cysteine and donates it to the FeS assembly. IscU and IscA function as scaffolds which … accept S and Fe, assemble them and transfer them to apoproteins. HscA is a molecular chaperone, while … HscB serves as its co-chaperone. Fdx is a [2Fe-2S] ferredoxin and IscR encodes a transcription factor
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SMP0120907
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Toll-Like Receptor Pathway 1
Mus musculus
Matched Description: lipoproteins, peptidoglycans, lipotechoic acids, and mannan. TLR3 recognizes viral double-stranded … RNA, small interfering RNAsa, and self-RNAs. TLR4 recognizes lipopolysaccharides. TLR7 recognizes … single-stranded RNA. TLR9 recognizes bacterial and viral DNA with unmethylated CpG-DNA motifs. TLRs … are synthesized in the endoplasmic reticulum, moved to the Golgi, and then recruited to the cell … . MYD88 is recruited by all TLRs. Adaptor TIRAP recruits MYD88 to cell surface TLRs, including TLR2 and
Matched Proteins: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 … TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Immunological
Pathogen-Activated Signaling
Gene Regulatory
Cellular Response
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SMP0412667
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Lipopolysaccharide Biosynthesis
Escherichia coli UMN026
Matched Description: either the fructose 6-phosphate produced by glycolysis and pyruvate dehydrogenase or obtained from the … and a glucosamine 6-phosphate. The latter compound is isomerized through a phosphoglucosamine mutase … through a bifunctional protein glmU resulting in a Coenzyme A, hydrogen ion and N-acetyl-glucosamine 1 … -phosphate. The latter interacts with UTP and hydrogen ion through the bifunctional protein glmU … resulting in a pyrophosphate and a UDP-N-acetylglucosamine. UDP-N-acetylglucosamine iinteracts with (3R)-3
Matched Proteins: outer membrane lipopolysaccharide transport and assembly complex - LptE subunit … outer membrane lipopolysaccharide transport and assembly complex - LptD subunit
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SMP0410518
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Lipopolysaccharide Biosynthesis
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Matched Description: either the fructose 6-phosphate produced by glycolysis and pyruvate dehydrogenase or obtained from the … and a glucosamine 6-phosphate. The latter compound is isomerized through a phosphoglucosamine mutase … through a bifunctional protein glmU resulting in a Coenzyme A, hydrogen ion and N-acetyl-glucosamine 1 … -phosphate. The latter interacts with UTP and hydrogen ion through the bifunctional protein glmU … resulting in a pyrophosphate and a UDP-N-acetylglucosamine. UDP-N-acetylglucosamine iinteracts with (3R)-3
Matched Proteins: outer membrane lipopolysaccharide transport and assembly complex - LptE subunit … outer membrane lipopolysaccharide transport and assembly complex - LptD subunit
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SMP0412756
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Lipopolysaccharide Biosynthesis
Escherichia coli ED1a
Matched Description: either the fructose 6-phosphate produced by glycolysis and pyruvate dehydrogenase or obtained from the … and a glucosamine 6-phosphate. The latter compound is isomerized through a phosphoglucosamine mutase … through a bifunctional protein glmU resulting in a Coenzyme A, hydrogen ion and N-acetyl-glucosamine 1 … -phosphate. The latter interacts with UTP and hydrogen ion through the bifunctional protein glmU … resulting in a pyrophosphate and a UDP-N-acetylglucosamine. UDP-N-acetylglucosamine iinteracts with (3R)-3
Matched Proteins: outer membrane lipopolysaccharide transport and assembly complex - LptE subunit … outer membrane lipopolysaccharide transport and assembly complex - LptD subunit
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SMP0126604
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Prochlorperazine Mechanism of Action Action Pathway
Homo sapiens
Matched Description: schizophrenia and anxiety and to relieve severe nausea and vomiting. Dopamine-antagonizing … medications such as prochlorperazine are thought to improve psychotic symptoms and states that are caused by … , and psychomotor agitation. However, this class of drugs is also limited by the development of … , tardive dyskinesia, as well as other side effects including sedation, weight gain, and prolactin … changes. It depresses the chemoreceptor trigger zone and blocking D2 dopamine receptors in the brain. It
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SMP0126623
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Pyridostigmine Action Pathway
Homo sapiens
Matched Description: usually administered intravenously and is very similar to neostigmine but with a less adverse effect … profile and longer duration of action. The autoimmune disease known as myasthenia gravis is … weakness, muscle loss and overall fatigue. Pyridostigmine inhibits the breakdown of acetylcholine allowing … for an increase in activation and relieving the aforementioned symptoms. It specifically targets … and inhibits acetylcholinesterase and cholinesterase, this increases extracellular levels of
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SMP0126379
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Darifenacin Action Pathway
Homo sapiens
Matched Description: found under the brand names Emselex and Enablex. Darifenacin blocks M3 muscarinic acetylcholine … receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it … darifenacin has greater affinity for the M3 receptor than for the other known muscarinic receptors (9 and 12 … -fold greater affinity for M3 compared to M1 and M5, respectively, and 59-fold greater affinity for … M3 compared to both M2 and M4). Muscarinic receptors play an important role in several major
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