SMP0122742
View Pathway
|
Sorafenib Action Pathway
Homo sapiens
Matched Description: (primary kidney cancer). It is an inhibitor of the RAF kinase protein and cell surface kinases PDGF-beta … receptor, VEGF 2 and 3 receptor (many sources also say VEGFR 1), c-KIT receptor, and FLT-3 receptor … angiogenesis which reduces blood flow to the tumor and also for genetic transcription for cell … proliferation and replication. Sorafenib's mechanism of action works by inhibiting the cell surface … kinases, which blocks their signalling to RAF and AKT pathways which are responsible for cell
|
SMP0174888
View Pathway
|
Mirtazapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: Mirtazapine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms … such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting … and are administered to attenuate inflammatory process in order to treat conditions such as allergic … rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T-cells … to inhibit the immune response, in blood vessels to constrict dilated blood vessels, and in smooth
|
SMP0174895
View Pathway
|
Meclizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: Meclizine is an H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and … hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy.
H1 … -antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered … conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune … response, in blood vessels to constrict dilated blood vessels, and in smooth muscles of lungs and
|
SMP0174977
View Pathway
|
Aripiprazole lauroxil H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: Aripiprazole lauroxil is an ethanolamine class H1 antihistamine used to treat insomnia and allergy … symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and … receptor and are administered to attenuate inflammatory process in order to treat conditions such … as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors … in T-cells to inhibit the immune response, in blood vessels to constrict dilated blood vessels, and
|
SMP0646831
View Pathway
|
Virulence (virB operon activation)
Bacteroides sp. 1_1_14
Matched Description: to virB11, and is responsible for transferring T-DNA and effector proteins from the bacterium into … peptidoglycan cell wall, facilitating insertion and assembly of T4SS. virB2 encodes the major pilin … subunit, which is processed and polymerized to form the T-pilus, which is essential for DNA transfer … to the plant cell. VirB3 encodes an inner membrane protein necessary for T-DNA secretion and it … interacts with virb4 to facilitate formation of the T-pilus. virB4 and VirB11 encode ATPases that
|
SMP0646838
View Pathway
|
Virulence (virB operon activation)
Bacteroides sp. 4_3_47FAA
Matched Description: to virB11, and is responsible for transferring T-DNA and effector proteins from the bacterium into … peptidoglycan cell wall, facilitating insertion and assembly of T4SS. virB2 encodes the major pilin … subunit, which is processed and polymerized to form the T-pilus, which is essential for DNA transfer … to the plant cell. VirB3 encodes an inner membrane protein necessary for T-DNA secretion and it … interacts with virb4 to facilitate formation of the T-pilus. virB4 and VirB11 encode ATPases that
|
SMP0646836
View Pathway
|
Virulence (virB operon activation)
Bacteroides sp. 3_1_33FAA
Matched Description: to virB11, and is responsible for transferring T-DNA and effector proteins from the bacterium into … peptidoglycan cell wall, facilitating insertion and assembly of T4SS. virB2 encodes the major pilin … subunit, which is processed and polymerized to form the T-pilus, which is essential for DNA transfer … to the plant cell. VirB3 encodes an inner membrane protein necessary for T-DNA secretion and it … interacts with virb4 to facilitate formation of the T-pilus. virB4 and VirB11 encode ATPases that
|
SMP0646832
View Pathway
|
Virulence (virB operon activation)
Bacteroides sp. 3_1_19
Matched Description: to virB11, and is responsible for transferring T-DNA and effector proteins from the bacterium into … peptidoglycan cell wall, facilitating insertion and assembly of T4SS. virB2 encodes the major pilin … subunit, which is processed and polymerized to form the T-pilus, which is essential for DNA transfer … to the plant cell. VirB3 encodes an inner membrane protein necessary for T-DNA secretion and it … interacts with virb4 to facilitate formation of the T-pilus. virB4 and VirB11 encode ATPases that
|
SMP0540404
View Pathway
|
Virulence (virB operon activation)
Salmonella enterica subsp. enterica serovar Agona str. SL483
Matched Description: to virB11, and is responsible for transferring T-DNA and effector proteins from the bacterium into … peptidoglycan cell wall, facilitating insertion and assembly of T4SS. virB2 encodes the major pilin … subunit, which is processed and polymerized to form the T-pilus, which is essential for DNA transfer … to the plant cell. VirB3 encodes an inner membrane protein necessary for T-DNA secretion and it … interacts with virb4 to facilitate formation of the T-pilus. virB4 and VirB11 encode ATPases that
|
SMP0646804
View Pathway
|
Virulence (virB operon activation)
Actinobacillus pleuropneumoniae serovar 3 str. JL03
Matched Description: to virB11, and is responsible for transferring T-DNA and effector proteins from the bacterium into … peptidoglycan cell wall, facilitating insertion and assembly of T4SS. virB2 encodes the major pilin … subunit, which is processed and polymerized to form the T-pilus, which is essential for DNA transfer … to the plant cell. VirB3 encodes an inner membrane protein necessary for T-DNA secretion and it … interacts with virb4 to facilitate formation of the T-pilus. virB4 and VirB11 encode ATPases that
|