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Matched Description: Diltiazem is a calcium channel blocker used to treat hypertension and to manage chronic stable … angina. It can be found under the names Cardizem, Cartia, Matzim, Taztia, Tiadylt, and Tiazac. Diltiazem … is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 … cardiac and vascular smooth muscle during depolarization. Compared to dihydropyridine drugs, such as … nifedipine, that preferentially act on vascular smooth muscle and verapamil that directly acts on

Matched Description: Diltiazem is a calcium channel blocker used to treat hypertension and to manage chronic stable … angina. It can be found under the names Cardizem, Cartia, Matzim, Taztia, Tiadylt, and Tiazac. Diltiazem … is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 … cardiac and vascular smooth muscle during depolarization. Compared to dihydropyridine drugs, such as … nifedipine, that preferentially act on vascular smooth muscle and verapamil that directly acts on

Matched Description: , including the lack or underdevelopment of the part of the brain that regulates balance and coordination … and an abnormal brain stem. The symptoms affect a variety of body parts in the patient, including … apnea, ataxia brought on by hypotonia, abnormal eye movements and intellectual disability. Many … molar tooth imprint that shows up on brain scans of the patient, a visualization of the malformed brain stem and cerebellar vermis.

Matched Proteins: Autophagy and beclin 1 regulator 1

Matched Description: , including the lack or underdevelopment of the part of the brain that regulates balance and coordination … and an abnormal brain stem. The symptoms affect a variety of body parts in the patient, including … apnea, ataxia brought on by hypotonia, abnormal eye movements and intellectual disability. Many … molar tooth imprint that shows up on brain scans of the patient, a visualization of the malformed brain stem and cerebellar vermis.

Matched Proteins: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Matched Description: Necroptosis is initiated by the activation of death receptors such as TNF receptors (TNFRSF1A and … TNFRSF10A) and FAS (TNFRSF6). When these receptors are activated by their ligands, they recruit FADD … and activate RIPK1. RIPK1 can then engage with RIPK3, forming the RIPK1-RIPK3 complex, which is … , membrane rupture, and release of intracellular contents. Moreover, interferons, such as interferon … inflammation and immune responses. The TRPM7 ion channel is also implicated in necroptosis by mediating

Matched Proteins: Signal transducer and activator of transcription 1-alpha/beta

Matched Description: start from the fructose 6-phosphate that is either produced in the glycolysis and pyruvate … resulting into a L-glutamic acid and a glucosamine 6-phosphate. The latter compound is isomerized through … and N-acetyl-glucosamine 1-phosphate. This compound interact with UTP and hydrogen ion through the … bifunctional protein glmU resulting in a pyrophosphate and a UDP-N-acetylglucosamine. This compound … resulting in a holo-[acp] and a UDP-3-O[(3R)-3-hydroxymyristoyl]-N-acetyl-alpha-D-glucosamine. This

Matched Proteins: Magnesium and cobalt efflux protein

Matched Description: either the fructose 6-phosphate produced by glycolysis and pyruvate dehydrogenase or obtained from the … and a glucosamine 6-phosphate. The latter compound is isomerized through a phosphoglucosamine mutase … through a bifunctional protein glmU resulting in a Coenzyme A, hydrogen ion and N-acetyl-glucosamine 1 … -phosphate. The latter interacts with UTP and hydrogen ion through the bifunctional protein glmU … resulting in a pyrophosphate and a UDP-N-acetylglucosamine. UDP-N-acetylglucosamine iinteracts with (3R)-3

Matched Proteins: ABC-type multidrug transport system, ATPase and permease components

Matched Description: acid, resulting in a fumaric acid and ubiquinol. Ubiquinone interacts with succinic acid through a … cofactors, ferroheme b, 2FE-2S, FAD, and 3Fe-4S iron-sulfur cluster. Then 2 ubiquinol interact with … oxygen and 4 hydrogen ion through a cytochrome bd-I terminal oxidase resulting in a 4 hydrogen ion … transferred into the periplasmic space, 2 water returned into the cytoplasm and 2 ubiquinone, which … and 4 hydrogen ion through a cytochrome bd-II terminal oxidase resulting in a 4 hydrogen ion

Matched Proteins: Succinate dehydrogenase and fumarate reductase iron-sulfur protein

Matched Description: either the fructose 6-phosphate produced by glycolysis and pyruvate dehydrogenase or obtained from the … and a glucosamine 6-phosphate. The latter compound is isomerized through a phosphoglucosamine mutase … through a bifunctional protein glmU resulting in a Coenzyme A, hydrogen ion and N-acetyl-glucosamine 1 … -phosphate. The latter interacts with UTP and hydrogen ion through the bifunctional protein glmU … resulting in a pyrophosphate and a UDP-N-acetylglucosamine. UDP-N-acetylglucosamine iinteracts with (3R)-3

Matched Proteins: ABC-type multidrug transport system, ATPase and permease component

Matched Description: acid, resulting in a fumaric acid and ubiquinol. Ubiquinone interacts with succinic acid through a … cofactors, ferroheme b, 2FE-2S, FAD, and 3Fe-4S iron-sulfur cluster. Then 2 ubiquinol interact with … oxygen and 4 hydrogen ion through a cytochrome bd-I terminal oxidase resulting in a 4 hydrogen ion … transferred into the periplasmic space, 2 water returned into the cytoplasm and 2 ubiquinone, which … and 4 hydrogen ion through a cytochrome bd-II terminal oxidase resulting in a 4 hydrogen ion

Matched Proteins: Succinate dehydrogenase and fumarate reductase iron-sulfur protein