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Search for '28cortisol oh aldosterone 22 and subject 3ametabolic' in 'all pathways' in 'all' returned 160470 results

SMP0125797

Pw127364 View Pathway
Metabolite

Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

Homo sapiens

  • Matched Description: , deoxycorticosterone, aldosterone and cortisol. Symptoms include salt-wasting crises in infancy due … to the lack of aldosterone, like spitting, poor weight gain, vomiting, severe dehydration, and … to aldosterone. A defect in this enzyme results in accumulation of 17-Hydroxyprogesterone … , progesterone and 17a-Hydroxypregnenolone, androstenedione, and testosterone; decreased levels of cortexolone … circulatory collapse. The high level of testosterone results in virilization and genital ambiguity of female infants.
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone … 17-oh progesterone

  • Disease

    SMP0125801

    Pw127368 View Pathway
    Metabolite

    Corticosterone Methyl Oxidase I Deficiency (CMO I)

    Homo sapiens

  • Matched Description: aldosterone deficiency among other names, is a genetic disorder that is autosomally linked and … , also called aldosterone synthase, which is used to catalyze the conversion of 18-hydroxycorticosterone … to aldosterone. This leads to a decrease in the amount of aldosterone present in the cells, which is … deficiency, aldosterone levels are so low that they are undetectable in plasma.
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone … 17-oh progesterone

  • Disease

    SMP0000575

    Pw000551 View Pathway
    Metabolite

    11-beta-Hydroxylase Deficiency (CYP11B1)

    Homo sapiens

  • Matched Description: recessive disorder and caused by a defective 11-beta-hydroxylase. 11-beta-hydroxylase catalyzes the … conversion of cortexolone into cortisol which is useful for maintaining blood sugar levels and … endoplasmic reticulum (ER). Symptoms of the disorder include abnormality of hair growth rate and
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone … 17-oh progesterone

  • Disease

    SMP0000718

    Pw000695 View Pathway
    Metabolite

    3-beta-Hydroxysteroid Dehydrogenase Deficiency

    Homo sapiens

  • Matched Description: metabolism (IEM) and autosomal recessive disorder of the steroidogenesis pathway. It is caused by an defect … produced, cortisol levels in the cell are lowered, and as cortisol is used in the production of other … of cortisol produced in the adrenal glands. Symptoms include abnormal genitalia for both males and
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone … 17-oh progesterone

  • Disease

    SMP0125804

    Pw127372 View Pathway
    Metabolite

    3-beta-Hydroxysteroid Dehydrogenase Deficiency

    Homo sapiens

  • Matched Description: metabolism (IEM) and autosomal recessive disorder of the steroidogenesis pathway. It is caused by an defect … produced, cortisol levels in the cell are lowered, and as cortisol is used in the production of other … of cortisol produced in the adrenal glands. Symptoms include abnormal genitalia for both males and
  • Matched Compounds: Aldosterone
  • Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone … 17-oh progesterone

  • Disease

    SMP0124888

    Pw126392 View Pathway
    Metabolite

    Carbimazole Action Pathway

    Homo sapiens

  • Matched Description: Carbimazole an imidazole antithyroid agent used for the treatment of hyperthyroidism and … enters the thyroid gland and is transported into thyroid follicle cells, where it inhibits the … production of the thyroid hormones T3 (liothyronine) and T4 (thyroxine). Thyroid hormone synthesis begins … -iodinated tyrosine (MIT) and di-iodinated tyrosine (DIT). The thyroglobulin molecules enter the follicle … lumen for this reaction via exocytosis. Coupling of MIT and DIT occurs, again using TPO. Coupling
  • Matched Protein Synonyms: Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide
  • Matched Compound Synonyms: [oh(oh)] … [oh(oh)] … [oh(oh)]

  • Drug Action

    SMP0000716

    Pw000693 View Pathway
    Metabolite

    Thyroid Hormone Synthesis

    Homo sapiens

  • Matched Description: metabolism, temperature regulation and growth/development. Thyroid hormone synthesis begins in the … nucleus of a thyroid follicular cell, as thyroglobulin synthesis occurs here and is transported to the … space, and then transported through exocytosis to the follicle colloid. There, thyroglobulin is … joined by iodide that has been transported from the blood, through the thyroid follicular cell and … arrived in the the follicle colloid using pendrin, and hydrogen peroxide to be catalyzed by thyroid
  • Matched Protein Synonyms: Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide
  • Matched Compound Synonyms: [oh(oh)] … [oh(oh)] … [oh(oh)] … [oh(oh)]

  • Metabolic

    SMP0126084

    Pw127662 View Pathway
    Metabolite

    Acemetacin Action Pathway

    Homo sapiens

  • Matched Description: Acemetacin is highly metabolized and degraded by esterolytic cleavage to form its major and active … symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a … approved. It has analgesic, antipyretic, and anti-inflammatory effects. It targets the prostaglandin G … /H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The … inducible enzyme, and during inflammation, it is responsible for prostaglandin synthesis. It leads to
  • Matched Proteins: Solute carrier family 22 member 6
  • Matched Compound Synonyms: for oral administration. acemetacin mode of action as an anti-inflammatory and antirheumatic agent may … be due to inhibition of synthesis and release of prostaglandins. the usefulness of indometacin, the … . acemetacin is highly metabolized and degraded by esterolytic cleavage to form its major and active … , n-desacylation and part of them are also transformed by conjugation with glucuronic acid. the … blood flow and glomerular filtration thus, acemetacin causes a decreased renal function, transient

  • Drug Action

    SMP0120470

    Pw121721 View Pathway
    Metabolite

    Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH

    Mus musculus

  • Matched Description: Congenital Lipoid Adrenal Hyperplasia (CLA),also called steroid 20-22 desmolase deficiency and … lipoid CAH, is an autosomal recessive disorder and caused by a defective cholesterol side-chain cleavage … disorder is not clear. Extra glucocorticoid and mineral replacement could be the potential treatments.
  • Matched Compounds: Aldosterone
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone … 17-oh progesterone

  • Disease

    SMP0120690

    Pw121946 View Pathway
    Metabolite

    Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH

    Rattus norvegicus

  • Matched Description: Congenital Lipoid Adrenal Hyperplasia (CLA),also called steroid 20-22 desmolase deficiency and … lipoid CAH, is an autosomal recessive disorder and caused by a defective cholesterol side-chain cleavage … disorder is not clear. Extra glucocorticoid and mineral replacement could be the potential treatments.
  • Matched Compounds: Aldosterone
  • Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosteroneAldosterone … 17-oh progesterone

  • Disease