SMP0125797
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Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
Homo sapiens
Matched Description: , deoxycorticosterone, aldosterone and cortisol. Symptoms include salt-wasting crises in infancy due … to the lack of aldosterone, like spitting, poor weight gain, vomiting, severe dehydration, and … to aldosterone. A defect in this enzyme results in accumulation of 17-Hydroxyprogesterone … , progesterone and 17a-Hydroxypregnenolone, androstenedione, and testosterone; decreased levels of cortexolone … circulatory collapse. The high level of testosterone results in virilization and genital ambiguity of female infants.
Matched Compounds: Aldosterone
Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … 17-oh progesterone
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SMP0125801
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Corticosterone Methyl Oxidase I Deficiency (CMO I)
Homo sapiens
Matched Description: aldosterone deficiency among other names, is a genetic disorder that is autosomally linked and … , also called aldosterone synthase, which is used to catalyze the conversion of 18-hydroxycorticosterone … to aldosterone. This leads to a decrease in the amount of aldosterone present in the cells, which is … deficiency, aldosterone levels are so low that they are undetectable in plasma.
Matched Compounds: Aldosterone
Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … 17-oh progesterone
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SMP0000575
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11-beta-Hydroxylase Deficiency (CYP11B1)
Homo sapiens
Matched Description: recessive disorder and caused by a defective 11-beta-hydroxylase. 11-beta-hydroxylase catalyzes the … conversion of cortexolone into cortisol which is useful for maintaining blood sugar levels and … endoplasmic reticulum (ER). Symptoms of the disorder include abnormality of hair growth rate and
Matched Compounds: Aldosterone
Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … 17-oh progesterone
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SMP0000718
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3-beta-Hydroxysteroid Dehydrogenase Deficiency
Homo sapiens
Matched Description: metabolism (IEM) and autosomal recessive disorder of the steroidogenesis pathway. It is caused by an defect … produced, cortisol levels in the cell are lowered, and as cortisol is used in the production of other … of cortisol produced in the adrenal glands. Symptoms include abnormal genitalia for both males and
Matched Compounds: Aldosterone
Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … 17-oh progesterone
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SMP0125804
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3-beta-Hydroxysteroid Dehydrogenase Deficiency
Homo sapiens
Matched Description: metabolism (IEM) and autosomal recessive disorder of the steroidogenesis pathway. It is caused by an defect … produced, cortisol levels in the cell are lowered, and as cortisol is used in the production of other … of cortisol produced in the adrenal glands. Symptoms include abnormal genitalia for both males and
Matched Compounds: Aldosterone
Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … 17-oh progesterone
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SMP0124888
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Carbimazole Action Pathway
Homo sapiens
Matched Description: Carbimazole an imidazole antithyroid agent used for the treatment of hyperthyroidism and … enters the thyroid gland and is transported into thyroid follicle cells, where it inhibits the … production of the thyroid hormones T3 (liothyronine) and T4 (thyroxine). Thyroid hormone synthesis begins … -iodinated tyrosine (MIT) and di-iodinated tyrosine (DIT). The thyroglobulin molecules enter the follicle … lumen for this reaction via exocytosis. Coupling of MIT and DIT occurs, again using TPO. Coupling
Matched Protein Synonyms: Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide
Matched Compound Synonyms: [oh(oh)] … [oh(oh)] … [oh(oh)]
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SMP0000716
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Thyroid Hormone Synthesis
Homo sapiens
Matched Description: metabolism, temperature regulation and growth/development. Thyroid hormone synthesis begins in the … nucleus of a thyroid follicular cell, as thyroglobulin synthesis occurs here and is transported to the … space, and then transported through exocytosis to the follicle colloid. There, thyroglobulin is … joined by iodide that has been transported from the blood, through the thyroid follicular cell and … arrived in the the follicle colloid using pendrin, and hydrogen peroxide to be catalyzed by thyroid
Matched Protein Synonyms: Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide … Neutrophil cytochrome b 22 kDa polypeptide
Matched Compound Synonyms: [oh(oh)] … [oh(oh)] … [oh(oh)] … [oh(oh)]
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SMP0126084
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Acemetacin Action Pathway
Homo sapiens
Matched Description: Acemetacin is highly metabolized and degraded by esterolytic cleavage to form its major and active … symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a … approved. It has analgesic, antipyretic, and anti-inflammatory effects. It targets the prostaglandin G … /H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The … inducible enzyme, and during inflammation, it is responsible for prostaglandin synthesis. It leads to
Matched Proteins: Solute carrier family 22 member 6
Matched Compound Synonyms: for oral administration. acemetacin mode of action as an anti-inflammatory and antirheumatic agent may … be due to inhibition of synthesis and release of prostaglandins. the usefulness of indometacin, the … . acemetacin is highly metabolized and degraded by esterolytic cleavage to form its major and active … , n-desacylation and part of them are also transformed by conjugation with glucuronic acid. the … blood flow and glomerular filtration thus, acemetacin causes a decreased renal function, transient
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SMP0120470
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Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
Mus musculus
Matched Description: Congenital Lipoid Adrenal Hyperplasia (CLA),also called steroid 20-22 desmolase deficiency and … lipoid CAH, is an autosomal recessive disorder and caused by a defective cholesterol side-chain cleavage … disorder is not clear. Extra glucocorticoid and mineral replacement could be the potential treatments.
Matched Compounds: Aldosterone
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … 17-oh progesterone
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SMP0120690
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Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
Rattus norvegicus
Matched Description: Congenital Lipoid Adrenal Hyperplasia (CLA),also called steroid 20-22 desmolase deficiency and … lipoid CAH, is an autosomal recessive disorder and caused by a defective cholesterol side-chain cleavage … disorder is not clear. Extra glucocorticoid and mineral replacement could be the potential treatments.
Matched Compounds: Aldosterone
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … 17-oh progesterone
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