SMP0126443
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Aprotinin Plasminogen Antifibrinolytic Action Pathway
Homo sapiens
Matched Description: and kallikrein. The drug is slowly metabolized by lysosomal enzymes and is eliminated through the … leading to various complications and in some cases death.
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SMP0126572
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Methylphenidate Norepinephrine Reuptake Inhibitor Action Pathway
Homo sapiens
Matched Description: (DAT1), the D4 receptor gene (DRD-4), and/or the D2 receptor gene. It has also been found to affect the … and norepinephrine to bind to the receptors. These receptors regulate attention, movement, and … reuptake transporters of both dopamine and norepinephrine which prolongs their duration in the … -hydroxylase. Norepinephrine is then transported to the prefrontal cortex and released into the synapse when … the neuron is stimulated and fires. Methylphenidate binds and blocks the sodium-dependent
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SMP0126926
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Gadodiamide Metabolism
Homo sapiens
Matched Description: procedures to assist in the visualization of blood vessels. It is intravenously injected and is … commonly marketed under the trade name Omniscan and used in MRI to visualize lesions with abnormal … vascularity in the brain (intracranial lesions), spine, and associated tissues. There is no detectable biotransformation or decomposition of gadodiamide.
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SMP0125940
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Ledipasvir Action Pathway
Homo sapiens
Matched Description: hepatocytes via receptor-mediated endocytosis. The lipoviroparticles attach to LDL-R and SR-B1, and … then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps … mature Hepatitis C virion and translated at the rough endoplasmic reticulum into a single Genome … polyprotein. The genome polyprotein is cleaved by host and viral proteases into 10 viral proteins. The … nucleocapsid protein core and the two envelope proteins E1 and E2 form the N terminus of the
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SMP0174897
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Tripelennamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory … process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and … vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax those … muscles.
H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are … rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T-cells to
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SMP0174902
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Diphenhydramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on … vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … , and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response, in
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SMP0174917
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Oxatomide H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 … vessels, and in smooth muscles of lungs and intestines to relax those muscles
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and
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SMP0174936
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Deptropine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 … vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and
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SMP0174941
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Terfenadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: with the agonist action of histamine at the H1 receptor and are administered to attenuate … inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and … vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax … those muscles.
H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and … rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T-cells to
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SMP0174953
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Dimetotiazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
Homo sapiens
Matched Description: histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat … conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on … vessels, and in smooth muscles of lungs and intestines to relax those muscles.
H1-antihistamines … interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate … , and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response, in
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