SMP0130951
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Heparin
Mus musculus
Matched Description: Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring … anticoagulants. Specifically it is also used in the treatment of heart attacks and unstable angina. It is given … inside blood specimen test tubes and kidney dialysis machines. Heparin acts as an anticoagulant … , preventing the formation of clots and extension of existing clots within the blood. While heparin … . Heparin is usually stored within the secretory granules of mast cells and released only into the
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SMP0130953
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Heparin
Bos taurus
Matched Description: Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring … anticoagulants. Specifically it is also used in the treatment of heart attacks and unstable angina. It is given … inside blood specimen test tubes and kidney dialysis machines. Heparin acts as an anticoagulant … , preventing the formation of clots and extension of existing clots within the blood. While heparin … . Heparin is usually stored within the secretory granules of mast cells and released only into the
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SMP0126325
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Pentazocine Opioid Antagonist Action Pathway
Homo sapiens
Matched Description: receptors and as an agonist of the kappa-type opioid receptor on neurons of the central nervous system (CNS … ). The binding of pentazocine on mu-type opioid receptors and kappa-type opioid receptors can lead … to decreased levels of neuronal excitability and hyperpolarization. The preponderance of evidence … . This allows calcium to enter the neuron and depolarize. The inhibition of mu-opioid receptors … depolarize and the high concentration of calcium releases GABA into the synapse which binds to GABA
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SMP0126574
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Salbutamol Action Pathway
Homo sapiens
Matched Description: , Proair, Proventil, Ventolin, and Xopenex. Salbutamol is a short-acting, selective beta2-adrenergic … receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 … - and S-isomers. The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer … and the S-isomer has been associated with toxicity. This lead to the development of levalbuterol … used for acute episodes of bronchospasm caused by bronchial asthma, chronic bronchitis and other
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SMP0012055
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cis-Zeatin-O-Glucoside Biosynthesis
Arabidopsis thaliana
Matched Description: , or cytokinesis, in plant roots and shoots. They are involved primarily in cell growth and … differentiation, but also affect apical dominance, axillary bud growth, and leaf senescence. Zeatin is an … prenylation of tRNA molecules and dimethylallyl diphosphate precursors provided through the mevalonate … cytokinins. O-glucosylation is reversible and is hypothesized to be involved with transport, storage, and … protection against zeatin oxidases. Only the enzymes that catalyze the first and last steps of
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SMP0130950
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Heparin
Homo sapiens
Matched Description: Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring … anticoagulants. Specifically it is also used in the treatment of heart attacks and unstable angina. It is given … inside blood specimen test tubes and kidney dialysis machines. Heparin acts as an anticoagulant … , preventing the formation of clots and extension of existing clots within the blood. While heparin … . Heparin is usually stored within the secretory granules of mast cells and released only into the
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SMP0130952
View Pathway
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Heparin
Rattus norvegicus
Matched Description: Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring … anticoagulants. Specifically it is also used in the treatment of heart attacks and unstable angina. It is given … inside blood specimen test tubes and kidney dialysis machines. Heparin acts as an anticoagulant … , preventing the formation of clots and extension of existing clots within the blood. While heparin … . Heparin is usually stored within the secretory granules of mast cells and released only into the
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SMP0001892
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ara Operon
Escherichia coli
Matched Description: arabinose is not present, it binds to the DNA in two specific locations, forming a loop in the DNA and … protein dimer, preventing it from forming the DNA loop and instead binding to the activator binding site … upstream of the promoter. This binding helps RNA polymerase to bind and transcribe the operon … absence of glucose, cAMP levels build up in the cell, and it can bind to and activate CRP. The … presence of both activated CRP and the arabinose operon regulatory protein promote the binding of RNA
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SMP0691496
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Oxygen - Fnr
Bacillus subtilis
Matched Description: The oxygen effector pathway, regulated by the Fnr (fumarate and nitrate reduction) regulog, plays a … . Under anaerobic (low oxygen) conditions, Fnr is activated and modulates gene expression to favor … , O2, is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and … concentration directly via the disassembly and reassembly of the [4Fe-4S] clusters. Anaerobic, de novo … containing two [4Fe-4S] clusters. This, in turn, enhances the affinity of FNR for specific DNA targets and
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SMP0125031
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Capecitabine Action Pathway (New)
Homo sapiens
Matched Description: indicated to treat colon, colorectal and breast cancer. Capecitabine is a prodrug, that is enzymatically … converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows … cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be … '-deoxyuridine 5'-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP), within normal and tumour … cells. These metabolites cause cell injury by two different mechanisms. First, FdUMP and the folate
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