SMP0503929
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Pyrimidine Deoxyribonucleosides Degradation
Methylibium sp. Pch-M
Matched Description: and a deoxycytidien deaminsa resultin in the release of a ammonium and a a deoxyuridine. The … -phosphate and a uracil.
The degradation of thymidine starts with thymidine being introduced into the … resulting in the release of a thymine and a deoxyribose 1-phosphate.
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SMP0512287
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Pyrimidine Ribonucleosides Degradation
Escherichia coli O127:H6 str. E2348/69
Matched Description: Cytidine and uridine are transported through their corresponding nucleoside hydrogen symporters … . Once cytidine is incorporated into the cytosol, it is deaminated through a reaction with water and a … hydrogen ion through a cytidine deaminase resulting in the release of ammonium and uridine. Uridine … and an alpha-D-ribose-1-phosphate. This compound is then transformed into an isomer D-ribose 5
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SMP0646410
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Toluene degradation
Dialister succinatiphilus YIT 11850
Matched Description: carbon and energy source. Toluene enters the bacterial cell by passive diffusion due to its hydrophobic … . Subsequently, Benzylsuccinyl-CoA undergoes a series of enzymatic reactions to form Benzoylsuccinyl-CoA, and … finally benzoyl-CoA, which enters the benzoate degradation pathway, providing the bacteria with energy and carbon for growth and survival.
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SMP0516021
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Toluene degradation
Mitsuokella multacida DSM 20544
Matched Description: carbon and energy source. Toluene enters the bacterial cell by passive diffusion due to its hydrophobic … . Subsequently, Benzylsuccinyl-CoA undergoes a series of enzymatic reactions to form Benzoylsuccinyl-CoA, and … finally benzoyl-CoA, which enters the benzoate degradation pathway, providing the bacteria with energy and carbon for growth and survival.
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SMP0525748
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Toluene degradation
Bacteroides intestinalis
Matched Description: carbon and energy source. Toluene enters the bacterial cell by passive diffusion due to its hydrophobic … . Subsequently, Benzylsuccinyl-CoA undergoes a series of enzymatic reactions to form Benzoylsuccinyl-CoA, and … finally benzoyl-CoA, which enters the benzoate degradation pathway, providing the bacteria with energy and carbon for growth and survival.
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SMP0526306
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Toluene degradation
Escherichia coli W
Matched Description: carbon and energy source. Toluene enters the bacterial cell by passive diffusion due to its hydrophobic … . Subsequently, Benzylsuccinyl-CoA undergoes a series of enzymatic reactions to form Benzoylsuccinyl-CoA, and … finally benzoyl-CoA, which enters the benzoate degradation pathway, providing the bacteria with energy and carbon for growth and survival.
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SMP0059114
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Levocetirizine H1-Antihistamine Action
Homo sapiens
Matched Description: (cetirizine). H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are … , allergic conjunctivitis, and urticaria. Reducing the activity of the NF-κB immune response … transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways … also decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion … molecules, and chemotactic factors. Furthermore, lowering calcium ion concentration leads to increased
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SMP0000348
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Globoid Cell Leukodystrophy
Homo sapiens
Matched Description: Globoid Cell Leukodistrophy (GLD), also called Krabbe disease and galactosylceramide lipidosis, is … population and a worldwide incidence of 1/100,000-1/250,000 live births. GLD is an autosomal recessive … is a lysosomal protein that hydrolyzes the galactose ester bonds of ceramides and ceramide … derivatives including galactocerebroside, galactosylsphingosine (psychosine), lactosylceramide, and … catabolism (via the removal of galactose) of galactosylceramide, a major lipid in myelin, kidney, and
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SMP0000470
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Fluorouracil Action Pathway
Homo sapiens
Matched Description: cancer, pancreatic cancer, breast cancer, and cervical cancer. As a cream, it is used for actinic … keratosis, basal cell carcinoma, and skin warts. Fluorouracil is on the World Health Organization's List … of Essential Medicines, the most effective and safe medicines needed in a health system … . Fluorouracil exerts cytotoxic effects on the cell by direct incorporation into DNA and RNA as well as by inhibiting thymidylate synthase.
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SMP0000637
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Tramadol Metabolism Pathway
Homo sapiens
Matched Description: the cytochrome CYP3A4 and CYP2B6 to form N-Desmethyltramadol, which further metabolized to N,N … -Didesmethyltramadol through CYP3A4 and CYP2B6 and to N,O-Didesmethyltramadol through CYP2D6. The O … metabolized to O-Desmethyltramadol glucuronide through UDP-glucuronosyltransferase 2B7 and UDP
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