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Matched Description: gadoxetate is hydrophillic and its moiety, the ethoxybenyzl group, is lipophillic. Consequently, gadoxetate … after bolus injection and then hepatocytes selectively takes up the drug. When gadoxetate disodium is … change the proton density and spin characteristics are detected and visualized by a device.

Matched Description: Clozapine is an antipsychotic drug used in treatment resistant schizophrenia and to decrease … drugs are vital in treating the core symptoms of schizophrenia: hallucinations and delusions As an … atypical antipsychotic, clozapine acts an antagonist to both dopamine and serotonin receptors … receptors in the mesolimbic pathway and 5-HT2A receptors in the frontal cortex. D2 antagonism relieves

Matched Description: Oseltamivir is a pro-drug neuraminidase inhibitor used in the prophylaxis and treatment of … influenza A (including pandemic H1N1) and B. Oseltamivir is extensively converted to the active metabolite … the inhibition of entry and release reduces viral shedding and infectivity.

Matched Description: drug, from the anthracycline class, is orally administered and has shown activity against breast … cancer, lymphomas, and leukemias. Idarubicin has antimitotic and cytotoxic activity. Firstly, idarubicin … expression, and produce free radical damage to DNA. Idarubicin possesses an antitumor effect against a

Matched Description: subclass of tricyclic antipsychotic agents. Loxapine is a dopamine antagonist and serotonin 5-HT2 blocker.

Matched Description: and lysophosphatidylinositol get transported into the cell through a phospholipid ATPase. Once in the

Matched Description: and lysophosphatidylinositol get transported into the cell through a phospholipid ATPase. Once in the

Matched Description: , interactions with the sugar phosphate backbone of residues in helices 31 and 34 via hydrogen bonds with … oxygen atoms and hydroxyl groups on the hydrophilic side of the tetracycline help anchor the drug in … position. Salt bridge interactions between the backbone of 16S rRNA and tetracycline are mediated by … the A site on the ribosome-RNA complex via steric hindrance. This causes inhibition of protein synthesis and hence bacterial cell growth.

Matched Description: protein 90, and translocate into the nucleus. In the nucleus, GR dimers can bind to glucocorticoid … ). GRs further interact with the transcription factors cAMP-responsive element binding protein and NF … -kappa-B, and inihibit their activation of inflammatory gene transcription. GRs also recruit histone … deacetylase 2 to inflammatory gene loci on DNA, which leads to DNA condensation and suppression of gene expression.

Matched Description: acyl-coenzyme A synthetase ACSM2B. Coenzyme A and ATP are also involved in this first step and AMP … and pyrophosphate will be generated during the first step of metabolism. In the second step … , phenylacetyl-CoA and L-glutamine interacts with glycine N-acyltransferase to generate coenzyme A as well as