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Matched Description: effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and … antiglaucoma agent. Metipranolol is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent … the pathogenesis of glaucomatous visual field loss and optic nerve damage. Metipranolol reduces … blocking agents reduce aqueous humor production, as demonstrated by tonography and fluorophotometry. A … metipranolol may include changes in vision, difficulty breathing, irregular heartbeat, and bloody nose.

Matched Description: oral antihypertensive therapy is not feasible or not desirable. Clevidipine is used IV only and … myocardial, smooth muscle and, therefore, has little or no effect on myocardial contractility or … , and without reducing central venous pressure or reducing cardiac output. Possibly by deforming the … channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium … the myocardial and vascular smooth muscle cell membranes. Some side effects of using clevidipine

Matched Description: also counters the effects of muscle relaxants, respiratory stimulants and other central nervous … disorders. Its mechanism of action is not fully known but is thought that the drug reversibly binds and … inhibits cholinesterase and acetylcholinesterase. Stopping the breakdown of acetylcholine leads to … cholinergic receptors being further stimulated and accumulating in the synaptic cleft. Tacrine is a … of mild to moderate dementia as seen in Alzheimer's. Symptoms of memory loss and deficiencies in

Matched Description: before bone marrow transplantation for acute myeloid leukemia and nonmalignant disease. This drug is cell … cycle-nonspecific and works by three different mechanisms. Those all lead to the disruption of the … DNA and the apoptosis of the cell. Busulfan contains two labile methanesulfonate groups. After the … hydrolyzation of the molecule, the methanesulfonate groups are released and carbonium ions are … replication and RNA transcription. Specifically, busulfan creates intrastrand crosslinks between

Matched Description: antimetabolite action. Tioguanine is indicated for remission induction and remission consolidation in the … hypoxanthine and guanine for the hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) and is itself … . Thioguanine nucleotides are incorporated into both the DNA and the RNA. The final result is the sequential … blockade of the usage and synthesis of purines, leading to apoptosis in the S phase of the cell cycle … nausea, vomiting, malaise, hypotension, and diaphoresis.

Matched Description: Morphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain … complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the … -operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This … results in hyperpolarization and reduced neuronal excitability. Morphine acts at A delta and C pain … and kappa opioid receptors in the nucleus accumbens where the reward pathway is activated.

Matched Description: microorganisms when rapid and high penicillin levels are required such as in the treatment of … septicemia, meningitis, pericarditis, endocarditis and severe pneumonia. Penicillin G inhibits penicillin … binding proteins. Penicillin binding proteins are responsible for glycosyltransferase and … transpeptidase reactions that lead to cross-linking of D-alanine and D-aspartic acid in bacterial cell walls … . Inhibition of this protein leads to upregulation of autolytic enzymes and inhibition of cell wall

Matched Description: oxoglutaric acid and UDP-4-amino-4-deoxy-beta-L-arabinopyranose The latter compound interacts with … a tetrahydrofolate, a hydrogen ion and a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose, which in … turn reacts with a product of the methylerythritol phosphate and polysoprenoid biosynthesis pathway … ditrans, octacis-undecaprenyl phosphate hypothetically reacts with water and results in the release … of a formic acid and 4-amino-4-deoxy-α-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate

Matched Description: oxoglutaric acid and UDP-4-amino-4-deoxy-beta-L-arabinopyranose The latter compound interacts with … a tetrahydrofolate, a hydrogen ion and a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose, which in … turn reacts with a product of the methylerythritol phosphate and polysoprenoid biosynthesis pathway … ditrans, octacis-undecaprenyl phosphate hypothetically reacts with water and results in the release … of a formic acid and 4-amino-4-deoxy-α-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate

Matched Description: as a carbon source and involves the conversion of benzoate into intermediates that can enter the … is activated by the benM gene which encodes for a transcriptional regulator and is outside of this … regulator, enhancing its ability to bind the promoter and facilitate RNA polymerase recruitment, thus … the catechil ortho-cleavage pathway and eventually feeds the TCA cycle. benB encodes benzoate 1,2 … operon is influenced by benK and benP which are also outside of the operon and encode for membrane