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Matched Description: , which leads to decreased arterial smooth muscle contractility and subsequent vasoconstriction … , calmodulin couldn't form the calcium-bound calmodulin, which is required for binding and activating … cells and results in vasodilation, which ultimately lead to overall decresing in blood pressure.

Matched Description: dermatomycosis and athlete's foot. It comes as a cream which is spread on the infected skin. Bifonazole inhibits … thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die.

Matched Description: inborn error of metabolism (IEM) and autosomal recessive disorder caused by either a homozygous or … generalized amino aciduria and marked galactosuria. Treatment usually includes galactose restricted … with galactokinase deficiency and classic galactosemia, patients with galactose epimerase deficiency

Matched Description: incontinence, urgency, and urinary frequency associated with an overactive bladder. It can be found … contraction of the smooth muscle wall surrounding the bladder. As a potent and selective muscarinic … using solifenacin may include dry mouth, headache, dizziness, and vertigo. Solifenacine is administered as an oral tablet.

Matched Description: loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult … stages of the susceptible parasites and depletes their glycogen stores. Degenerative changes in the … endoplasmic reticulum, the mitochondria, and the subsequent release of lysosomes result in decreased

Matched Description: to bind to VEGF, reducing both angiogenesis and vessel permeability, particularly for neovascular … , and inflammation that contribute to the progression of wet age-related macular degeneration, a … approach is especially effective for patients with conditions like wet AMD, where VEGF-A levels are elevated and contribute to disease progression.

Matched Description: Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG). Because of the inhibition, IP3 doesn't … activate the release of calcium from the sarcoplasmic reticulum, and DAG doesn't activate the … in the cytosol, and it, therefore, cannot bind to calmodulin.Calcium bound calmodulin is required for

Matched Description: doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg). Reverse … of replication. Doravirine is taken orally and transported into the cell via a drug transporter … are therefore produced, and there is a reduction in new viruses being formed.

Matched Description: the HIV-1 provirus and propagation of the viral infection. Elvitegravir is transported into the … prevents the viral DNA from being integrated into the host DNA. This prevents viral replication and … which further prevents viral replication and progression of the virus.

Matched Description: release of a hydrogen ion, a pyrophosphate and a alpha-Dribose-1-methylphosphonate 5-phosphate. The … and a 5-phospho-alpha-D-ribose 1,2-cyclic phosphate. This compound in turn gets degraded by a water … driven 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase resulting in the release of a hydrogen ion and a alpha-D-ribose 1,5-biphosphate.