SMP0402997
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Valine Biosynthesis
Bacteroides coprocola
Matched Description: / acetolactate synthase resulting in the release of carbon dioxide and (S)-2-acetolactate. The latter … resulting in the release of a NADP and an (R) 2,3-dihydroxy-3-methylvalerate. The latter compound is … then dehydrated by a dihydroxy acid dehydratase resulting in the release of water and isovaleric … oxoglutaric acid and an L-valine. L-valine is then transported into the periplasmic space through a L-valine efflux transporter.
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SMP0403871
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Valine Biosynthesis
Escherichia coli O103:H2 str. 12009
Matched Description: / acetolactate synthase resulting in the release of carbon dioxide and (S)-2-acetolactate. The latter … resulting in the release of a NADP and an (R) 2,3-dihydroxy-3-methylvalerate. The latter compound is … then dehydrated by a dihydroxy acid dehydratase resulting in the release of water and isovaleric … oxoglutaric acid and an L-valine. L-valine is then transported into the periplasmic space through a L-valine efflux transporter.
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SMP0403746
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Valine Biosynthesis
Escherichia coli UMN026
Matched Description: / acetolactate synthase resulting in the release of carbon dioxide and (S)-2-acetolactate. The latter … resulting in the release of a NADP and an (R) 2,3-dihydroxy-3-methylvalerate. The latter compound is … then dehydrated by a dihydroxy acid dehydratase resulting in the release of water and isovaleric … oxoglutaric acid and an L-valine. L-valine is then transported into the periplasmic space through a L-valine efflux transporter.
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SMP0405855
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Valine Biosynthesis
Raoultella planticola
Matched Description: / acetolactate synthase resulting in the release of carbon dioxide and (S)-2-acetolactate. The latter … resulting in the release of a NADP and an (R) 2,3-dihydroxy-3-methylvalerate. The latter compound is … then dehydrated by a dihydroxy acid dehydratase resulting in the release of water and isovaleric … oxoglutaric acid and an L-valine. L-valine is then transported into the periplasmic space through a L-valine efflux transporter.
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SMP0125115
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Pregabalin Action Pathway
Homo sapiens
Matched Description: Pregabalin is an anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia … , and for the treatment of partial onset seizures in combination with other anticonvulsants.
Pregabalin … properties include anxiolytic, anticonvulsant and analgesic effects.
Although the structure of … amino acid glutamine and transported into synaptic vesicles by excitatory amino acid transporter and … neurotransmitter, thus, once it gets in the synapse it activates NMDA and AMPA receptors. Activation
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SMP0122740
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Isoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway
Homo sapiens
Matched Description: administered via IV or oral inhalation and is used to treat conditions including mild or transient episodes … of heart block that do not require pacing, serious episodes of heart block and Adams-Stokes attacks … or pacemaker therapy is available, bronchospasm occurring during anesthesia, and as an adjunct to … in the treatment of hypovolemic and septic shock, low cardiac output states, congestive heart failure … , and cardiogenic shock.
The actions of isoprenaline are mostly observed in heart muscle, where it
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SMP0127028
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Gq Serotonergic Smooth Muscle Contraction
Rattus norvegicus
Matched Description: due to its prominent role in promoting airway smooth muscle contraction and contraction of the … gastrointestinal tract. Once activated, serotonin functions to mobilize intestinal contraction and … a conformational change that promotes its association with and activation of the heterotrimeric G … protein Gq. The extreme C-terminus of the G alpha subunit is the receptor recognition domain and … dictates receptor-Gα specificity. Receptor-Gα association promotes the release of GDP from Gα and binding
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SMP0126954
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Gq Serotonergic Smooth Muscle Contraction
Homo sapiens
Matched Description: due to its prominent role in promoting airway smooth muscle contraction and contraction of the … gastrointestinal tract. Once activated, serotonin functions to mobilize intestinal contraction and … a conformational change that promotes its association with and activation of the heterotrimeric G … protein Gq. The extreme C-terminus of the G alpha subunit is the receptor recognition domain and … dictates receptor-Gα specificity. Receptor-Gα association promotes the release of GDP from Gα and binding
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SMP0123142
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Hydroflumethiazide Diuretic Action Pathway
Homo sapiens
Matched Description: heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the … regulation of ions such as sodium, potassium, calcium, chloride and magnesium occur. In epithelial … interstitium-blood area and K+ into the epithelial cell; the Na+/Ca2+ exchanger, which pumps Na+ into … the cell and Ca2+ into the interstitium-blood; and the chloride transporter which transports chloride … epithelial cell and a Na+/Cl- cotransporter which transports Na+ and Cl- into the epithelial cell
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SMP0127030
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Gq Serotonergic Smooth Muscle Contraction
Bos taurus
Matched Description: due to its prominent role in promoting airway smooth muscle contraction and contraction of the … gastrointestinal tract. Once activated, serotonin functions to mobilize intestinal contraction and … a conformational change that promotes its association with and activation of the heterotrimeric G … protein Gq. The extreme C-terminus of the G alpha subunit is the receptor recognition domain and … dictates receptor-Gα specificity. Receptor-Gα association promotes the release of GDP from Gα and binding
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