SMP0000086
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Ibuprofen Action Pathway
Homo sapiens
Matched Compounds: 12-Keto-leukotriene B4 … δ-12-Prostaglandin J2 … 12(R)-HPETE … 12(S)-HPETE … 12(R)-HETE
Matched Proteins: Arachidonate 12-lipoxygenase, 12R-type … Arachidonate 12-lipoxygenase, 12S-type
Matched Protein Synonyms: Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … p53-induced gene 12 protein … Cytochrome P450 MP-12 … Cytochrome P450 MP-12
Matched Compound Synonyms: 5(s),12(r)-dihydroxy-20-carboxy-6,8,10,14-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate
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SMP0000353
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Leukotriene C4 Synthesis Deficiency
Homo sapiens
Matched Compounds: 12-Keto-leukotriene B4 … δ-12-Prostaglandin J2 … 12(R)-HPETE … 12(S)-HPETE … 12(R)-HETE
Matched Proteins: Arachidonate 12-lipoxygenase, 12R-type … Arachidonate 12-lipoxygenase, 12S-type
Matched Protein Synonyms: p53-induced gene 12 protein … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12
Matched Compound Synonyms: 5(s),12(r)-dihydroxy-20-carboxy-6,8,10,14-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate
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SMP0000077
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Piroxicam Action Pathway
Homo sapiens
Matched Compounds: 12-Keto-leukotriene B4 … δ-12-Prostaglandin J2 … 12(R)-HPETE … 12(S)-HPETE … 12(R)-HETE
Matched Proteins: Arachidonate 12-lipoxygenase, 12R-type … Arachidonate 12-lipoxygenase, 12S-type
Matched Protein Synonyms: p53-induced gene 12 protein … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12
Matched Compound Synonyms: 5(s),12(r)-dihydroxy-20-carboxy-6,8,10,14-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate
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SMP0000087
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Rofecoxib Action Pathway
Homo sapiens
Matched Description: coupled receptors, thomboxane A2 receptor and P2Y purinoreceptor 12, and inhibit the production of
Matched Compounds: 12-Keto-leukotriene B4 … δ-12-Prostaglandin J2 … 12(R)-HPETE … 12(S)-HPETE … 12(R)-HETE
Matched Proteins: Arachidonate 12-lipoxygenase, 12R-type … Arachidonate 12-lipoxygenase, 12S-type
Matched Protein Synonyms: p53-induced gene 12 protein … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12
Matched Compound Synonyms: 5(s),12(r)-dihydroxy-20-carboxy-6,8,10,14-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate
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SMP0000120
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Naproxen Action Pathway
Homo sapiens
Matched Compounds: 12-Keto-leukotriene B4 … δ-12-Prostaglandin J2 … 12(R)-HPETE … 12(S)-HPETE … 12(R)-HETE
Matched Proteins: Arachidonate 12-lipoxygenase, 12R-type … Arachidonate 12-lipoxygenase, 12S-type
Matched Protein Synonyms: p53-induced gene 12 protein … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12
Matched Compound Synonyms: 5(s),12(r)-dihydroxy-20-carboxy-6,8,10,14-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate
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SMP0000106
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Meloxicam Action Pathway
Homo sapiens
Matched Description: P2Y purinoreceptor 12, and inhibit the production of cAMP via adenylate cyclase inhibition. This
Matched Compounds: 12-Keto-leukotriene B4 … δ-12-Prostaglandin J2 … 12(R)-HPETE … 12(S)-HPETE … 12(R)-HETE
Matched Proteins: Arachidonate 12-lipoxygenase, 12R-type … Arachidonate 12-lipoxygenase, 12S-type
Matched Protein Synonyms: p53-induced gene 12 protein … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12
Matched Compound Synonyms: 5(s),12(r)-dihydroxy-20-carboxy-6,8,10,14-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate
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SMP0000693
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Antrafenine Action Pathway
Homo sapiens
Matched Compounds: 12-Keto-leukotriene B4 … δ-12-Prostaglandin J2 … 12(R)-HPETE … 12(S)-HPETE … 12(R)-HETE
Matched Proteins: Arachidonate 12-lipoxygenase, 12R-type … Arachidonate 12-lipoxygenase, 12S-type
Matched Protein Synonyms: p53-induced gene 12 protein … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12
Matched Compound Synonyms: 5(s),12(r)-dihydroxy-20-carboxy-6,8,10,14-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate
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SMP0000698
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Magnesium Salicylate Action Pathway
Homo sapiens
Matched Compounds: 12-Keto-leukotriene B4 … δ-12-Prostaglandin J2 … 12(R)-HPETE … 12(S)-HPETE … 12(R)-HETE
Matched Proteins: Arachidonate 12-lipoxygenase, 12R-type … Arachidonate 12-lipoxygenase, 12S-type
Matched Protein Synonyms: p53-induced gene 12 protein … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12
Matched Compound Synonyms: 5(s),12(r)-dihydroxy-20-carboxy-6,8,10,14-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate
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SMP0000705
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Tiaprofenic Acid Action Pathway
Homo sapiens
Matched Compounds: 12-Keto-leukotriene B4 … δ-12-Prostaglandin J2 … 12(R)-HPETE … 12(S)-HPETE … 12(R)-HETE
Matched Proteins: Arachidonate 12-lipoxygenase, 12R-type … Arachidonate 12-lipoxygenase, 12S-type
Matched Protein Synonyms: p53-induced gene 12 protein … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12
Matched Compound Synonyms: 5(s),12(r)-dihydroxy-20-carboxy-6,8,10,14-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate
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SMP0000710
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Acetaminophen Action Pathway
Homo sapiens
Matched Compounds: 12-Keto-leukotriene B4 … δ-12-Prostaglandin J2 … 12(R)-HPETE … 12(S)-HPETE … 12(R)-HETE
Matched Proteins: Arachidonate 12-lipoxygenase, 12R-type … Arachidonate 12-lipoxygenase, 12S-type
Matched Protein Synonyms: p53-induced gene 12 protein … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12 … Cytochrome P450 MP-12
Matched Compound Synonyms: 5(s),12(r)-dihydroxy-20-carboxy-6,8,10,14-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoic acid … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-eicosatetraenoate … 5(s),12(r)-dihydroxy-6(z),8(e),10(e),14(z)-icosatetraenoate
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