SMP0000134
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Spironolactone Action Pathway
Homo sapiens
Matched Description: receptor inside the principal cells of the late distal tubule and collecting tubule. Aldosterone … Spironolactone is a potassium-sparing diuretic. It acts by competing with aldosterone for its … increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium … -potassium ATPases as well as luminal (apical) sodium and potassium channels. Sodium in the nephron … hyperosmotic and establishes an osmotic gradient, facilitating water reabsorption through aquaporin
Matched Compounds: Aldosterone
Matched Proteins: Solute carrier family 22 member 6 … Solute carrier family 22 member 2 … Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … [co2(oh)](-)
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SMP0000371
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Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
Homo sapiens
Matched Description: Congenital Lipoid Adrenal Hyperplasia (CLA),also called steroid 20-22 desmolase deficiency and … lipoid CAH, is an autosomal recessive disorder and caused by a defective cholesterol side-chain cleavage … disorder is not clear. Extra glucocorticoid and mineral replacement could be the potential treatments.
Matched Compounds: Aldosterone
Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … 17-oh progesterone
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SMP0000135
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Eplerenone Action Pathway (Old)
Homo sapiens
Matched Description: inside the principal cells of the late distal tubule and collecting tubule. Aldosterone increases … Eplerenone is a potassium-sparing diuretic. It acts by competing with aldosterone for its receptor … sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium … -potassium ATPases as well as luminal (apical) sodium and potassium channels. Sodium in the nephron lumen … hyperosmotic and establishes an osmotic gradient, facilitating water reabsorption through aquaporin channels
Matched Compounds: Aldosterone
Matched Proteins: Solute carrier family 22 member 6 … Solute carrier family 22 member 2 … Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … [co2(oh)](-)
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SMP0125798
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Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
Homo sapiens
Matched Description: Congenital Lipoid Adrenal Hyperplasia (CLA),also called steroid 20-22 desmolase deficiency and … lipoid CAH, is an autosomal recessive disorder and caused by a defective cholesterol side-chain cleavage … disorder is not clear. Extra glucocorticoid and mineral replacement could be the potential treatments.
Matched Compounds: Aldosterone
Matched Protein Synonyms: Aldosterone synthase … Aldosterone-synthesizing enzyme … Aldosterone synthase … Aldosterone-synthesizing enzyme … Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a
Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … 17-oh progesterone
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SMP0000585
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Lysinuric Protein Intolerance (LPI)
Homo sapiens
Matched Description: of metabolism (IEM) and autosomal recessive disorder of the kidney function pathway. It is caused … involved in the uptake of amino acids, both with sodium for neutral amino acids, and without for … dibasic amino acids. In this disorder, the amino acids lysin, arginine and ornithine, found in protein … urea cycle. LPI is characterized by a shortage of lysine, arginine and ornithine within the body … after weaning, nausea and vomiting following a meal containing large amounts of protein, as well as
Matched Compounds: Aldosterone
Matched Proteins: Solute carrier family 22 member 6 … Solute carrier family 22 member 2 … Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000080
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Polythiazide Action Pathway
Homo sapiens
Matched Description: reabsorption that count for 5% of total amount. Solute carrier family 12 member 3 transports chloride and … sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium
Matched Compounds: Aldosterone
Matched Proteins: Solute carrier family 22 member 6 … Solute carrier family 22 member 2 … Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000122
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Chlorthalidone Action Pathway
Homo sapiens
Matched Description: transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the
Matched Compounds: Aldosterone
Matched Proteins: Solute carrier family 22 member 6 … Solute carrier family 22 member 2 … Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000103
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Cyclothiazide Action Pathway
Homo sapiens
Matched Description: and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of
Matched Compounds: Aldosterone
Matched Proteins: Solute carrier family 22 member 6 … Solute carrier family 22 member 2 … Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000118
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Torsemide Action Pathway
Homo sapiens
Matched Description: the drug class of loop diuretics. It is commonly used to manage hypertension and edema in cases of … reduces the uptake of water and serves to both increase water loss and reduce blood pressure
Matched Compounds: Aldosterone
Matched Proteins: Solute carrier family 22 member 6 … Solute carrier family 22 member 2 … Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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SMP0000583
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Blue Diaper Syndrome
Homo sapiens
Matched Description: symptoms can include bacterial infections, damage to various parts of the eye, hypercalcemia, and impaired … hypercalcemia, and a tryptophan restricted diet to prevent all systems. If bacterial infections are common, antibiotics may be prescribed.
Matched Compounds: Aldosterone
Matched Proteins: Solute carrier family 22 member 6 … Solute carrier family 22 member 2 … Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT
Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule
Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)
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