Netilmicin is a member of the aminoglycoside family of antibiotics that is produced by fermentation of Micromonospora inyoensis. Netilmicin can effectively against a wide variety of pathogenic bacteria such as E.coli, Citrobacter sp., etc. Netilmicin can also effectively against Hemophilus influenzae, Salmonella sp. and others in vitro. However, netilmicin are ineffective against anaerobic bacteria, fungi and viruses. Netilmicin binds irreversibly to the bacterial 30S ribosomal subunit protein and 16S rRNA and prevents the formation of the initiation complex with messenger RNA. Binding of netilmicin can cause misreading of mRNA which result in insertion of incorrect amino acids to polypeptide. This lead to nonfunctional or toxic peptides of protein complex.

Netilmicin Pathway References