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Histone-lysine N-
methyltransferase
SETD7
Trimethyllysine
dioxygenase,
mitochondrial
Serine
hydroxymethyltransferase,
cytosolic
4-
trimethylaminobutyraldehyde
dehydrogenase
Gamma-
butyrobetaine
dioxygenase
N6,N6,N6-
Trimethyl-L-
lysine
N6,N6,N6-
Trimethyl-L-
lysine
4-
Trimethylammoniobutanoic
acid
4-
Trimethylammoniobutanoic
acid
L-Lysine
S-
Adenosylmethionine
S-
Adenosylhomocysteine
Oxoglutaric acid
O
2
3-Hydroxy-
N6,N6,N6-
trimethyl-L-
lysine
Succinic acid
CO
2
Glycine
4-
Trimethylammoniobutanal
NAD
H
2
O
NADH
H
+
Oxoglutaric acid
O
2
L-Carnitine
Succinic acid
CO
2
Fe2+
Fe2+
Ascorbic acid
Protein
containing a
lysine residue
Protein
containing a
lysine residue
Protein
degradation
Pyridoxal
5'-phosphate
Nucleus
Nuclear Membrane
Nucleoplasm
Extacellular Space
Intracellular Space
Intracellular Space
Mitochondria
Liver
Kidney
Nucleus
SETD7
TMLHE
SHMT1
ALDH9A1
BBOX1
N6,N6,N6-
Trimethyl-L-
lysine
N6,N6,N6-
Trimethyl-L-
lysine
4-
Trimethylammoniobutanoic
acid
4-
Trimethylammoniobutanoic
acid
L-Lysine
S-
Adenosylmethionine
S-
Adenosylhomocysteine
Oxoglutaric acid
Oxygen
3-Hydroxy-
N6,N6,N6-
trimethyl-L-
lysine
Succinic acid
Carbon dioxide
Glycine
4-
Trimethylammoniobutanal
NAD
Water
NADH
Hydrogen Ion
Oxoglutaric acid
Oxygen
L-Carnitine
Succinic acid
Carbon dioxide
Protein
containing a
lysine residue
Protein
containing a
lysine residue
Protein
degradation
SETD7
TMLHE
SHMT1
ALDH9A1
BBOX1
TML-Lys
TML-Lys
4-TMaba
4-TMaba
Lys
SAMe
SAH
AKG
O
2
3HNNNTL
Succini
CO
2
Gly
4-TMAmB
NAD
H
2
O
NADH
H
+
AKG
O
2
L-Carnt
Succini
CO
2
Fe2+
Fe2+
VitC
PCALR
PCALR
Pro deg
Pyr-5'P
Nucleus
Nuclear Membrane
Nucleoplasm
Extacellular Space
Intracellular Space
Intracellular Space
Mitochondria
Liver
Kidney