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Pathway Description
Lamivudine Action Pathway
Homo sapiens
Category:
Metabolite Pathway
Sub-Category:
Drug Action
Created: 2014-06-23
Last Updated: 2019-08-16
Lamivudine (also known as 3TC) is an antiretroviral drug that can be used to treat HIV/AIDS. Lamivudine is phosphorylated to lamivudine triphosphate (L-TP), which is its active metabolite. Lamivudine triphosphate (L-TP) can bind and inhibit the HIV reverse transcriptase as well as HBV polymerase, which lead to DNA chain termination.
References
Lamivudine Pathway References
Caroline M. Perry and Diana Faulds. Lamivudine A Review of its Antiviral Activity, Pharmacokinetic Properties and Therapeutic Efficacy in the Management of HIV Infection. Drugs, April 1997, Volume 53, Issue 4, pp 657–680
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