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Transcriptional
regulator LsrR
AI-2 transport
protein TqsA
AI-2 transport
protein TqsA
5'-
methylthioadenosine/S-
adenosylhomocysteine
nucleosidase
S-
ribosylhomocysteine
lyase
autoinducer-2
kinase
phospho-AI-2
isomerase
3-hydroxy- 2,4-
pentadione
5-phosphate
thiolase
S-
ribosylhomocysteine
lyase
Autoinducer 2
import system
permease
protein lsrC
Autoinducer 2
import system
permease
protein lsrD
Autoinducer-2
ABC transporter
- periplasmic
binding protein
B
AI-2 ABC
transporter -
ATP binding
subunit A
(2R,4S)-2-
methyl-
2,3,3,4-
tetrahydroxytetrahydrofuran
(2R,4S)-2-
methyl-
2,3,3,4-
tetrahydroxytetrahydrofuran
(2R,4S)-2-
methyl-
2,3,3,4-
tetrahydroxytetrahydrofuran
S-
Adenosylhomocysteine
H
2
O
Adenine
S-ribosyl-L-
homocysteine
Homocysteine
autoinducer 2
(2R,4S)-2-
methyl-2,4-
dihydroxydihydrofuran-
3-one
H
2
O
(2R,4S)-2-
methyl-
2,3,3,4-
tetrahydroxytetrahydrofuran
ATP
ADP
H
+
(4S)-4-
hydroxy-2,3-
pentanedione
5-phosphate
3-hydroxy- 2,4-
pentanedione
5-phosphate
CoA
Acetyl-CoA
Dihydroxyacetone
phosphate
S-
Adenosylmethionine
Dimethylglycine
H
+
βine
S-ribosyl-L-
homocysteine
4,5- Dihydroxy-
2,3-
pentanedione
Homocysteine
(2R,4S)-2-
methyl-
2,3,3,4-
tetrahydroxytetrahydrofuran
Phosphoribosyl-
ATP
H
2
O
ADP
H
+
PP
i
3-hydroxy- 2,4-
pentanedione
5-phosphate
S-Adenosyl-L-
Methionine
Biosynthesis
Transcription of lsrK, lsrR,
lsrA, lsrC, lsrD, lsrB,
lsrF, lsrG, tam, yneE
lsrR
tqsA
tqsA
mtn
luxS
lsrK
lsrG
lsrF
luxS
lsrC
lsrD
lsrB
lsrA
(2R,4S)-2-
methyl-
2,3,3,4-
tetrahydroxytetrahydrofuran
(2R,4S)-2-
methyl-
2,3,3,4-
tetrahydroxytetrahydrofuran
(2R,4S)-2-
methyl-
2,3,3,4-
tetrahydroxytetrahydrofuran
S-
Adenosylhomocysteine
Water
Adenine
S-ribosyl-L-
homocysteine
Homocysteine
autoinducer 2
(2R,4S)-2-
methyl-2,4-
dihydroxydihydrofuran-
3-one
Water
(2R,4S)-2-
methyl-
2,3,3,4-
tetrahydroxytetrahydrofuran
Adenosine
triphosphate
Adenosine
diphosphate
Hydrogen Ion
(4S)-4-
hydroxy-2,3-
pentanedione
5-phosphate
3-hydroxy- 2,4-
pentanedione
5-phosphate
Coenzyme A
Acetyl-CoA
Dihydroxyacetone
phosphate
S-
Adenosylmethionine
Dimethylglycine
Hydrogen Ion
βine
S-ribosyl-L-
homocysteine
4,5- Dihydroxy-
2,3-
pentanedione
Homocysteine
(2R,4S)-2-
methyl-
2,3,3,4-
tetrahydroxytetrahydrofuran
Phosphoribosyl-
ATP
Water
Adenosine
diphosphate
Hydrogen Ion
Pyrophosphate
3-hydroxy- 2,4-
pentanedione
5-phosphate
S-Adenosyl-L-
Methionine
Biosynthesis