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Lysine-
sensitive
aspartokinase 3
Aspartate-
semialdehyde
dehydrogenase
Bifunctional
aspartokinase/homoserine
dehydrogenase 2
Bifunctional
aspartokinase/homoserine
dehydrogenase 1
Homoserine
kinase
Threonine
synthase
Dihydrodipicolinate
synthase
L-Aspartic acid
L-Threonine
ATP
ADP
L-Aspartyl-4-
phosphate
NADPH
H
+
P
i
NADP
L-Aspartate-
semialdehyde
H
+
NADPH
NADP
L-Homoserine
ATP
ADP
H
+
O-
Phosphohomoserine
H
2
O
P
i
Pyruvic acid
H
2
O
L-2,3-
Dihydrodipicolinate
Aspartate
Metabolism
Propanoate
Metabolism
lysC
asd
metL
thrA
thrB
thrC
dapA
L-Aspartic acid
L-Threonine
Adenosine
triphosphate
Adenosine
diphosphate
L-Aspartyl-4-
phosphate
NADPH
Hydrogen Ion
Phosphate
NADP
L-Aspartate-
semialdehyde
Hydrogen Ion
NADPH
NADP
L-Homoserine
Adenosine
triphosphate
Adenosine
diphosphate
Hydrogen Ion
O-
Phosphohomoserine
Water
Phosphate
Pyruvic acid
Water
L-2,3-
Dihydrodipicolinate
Aspartate
Metabolism
Propanoate
Metabolism
lysC
asd
metL
thrA
thrB
thrC
dapA
Asp
Thr
ATP
ADP
LA4P
NADPH
H
+
P
i
NADP
L-Aspar
H
+
NADPH
NADP
Homoser
ATP
ADP
H
+
OPPHS
H
2
O
P
i
Pyr
H
2
O
Dihydro
PW000787
PW000940