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Pathway Description
Purine Degradation
Escherichia coli
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-09-09
Last Updated: 2025-07-30
Pseudouridine is phosphorylated by interacting with atp and a psuK resulting in the release of an ADP, a hydrogen ion and a pseudouridine 5'-phosphate. The latter compound then reacts with water through a pseudouridine 5'-phosphate glycosidase resulting in the release of a uracil and D-ribofuranose 5-phosphate
References
Purine Degradation References
Breitman TR, Scher CD: Growth of pyrimidineless strains of Escherichia coli on 5-ribosyluracil (pseudouridine). J Bacteriol. 1968 Nov;96(5):1873-4.
Pubmed: 4882030
Breitman TR: Pseudouridulate synthetase of Escherichia coli: correlation of its activity with utilization of pseudouridine for growth. J Bacteriol. 1970 Jul;103(1):263-4.
Pubmed: 4912525
Del Campo M, Kaya Y, Ofengand J: Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli. RNA. 2001 Nov;7(11):1603-15.
Pubmed: 11720289
Ferre-D'Amare AR: RNA-modifying enzymes. Curr Opin Struct Biol. 2003 Feb;13(1):49-55.
Pubmed: 12581659
Huang L, Pookanjanatavip M, Gu X, Santi DV: A conserved aspartate of tRNA pseudouridine synthase is essential for activity and a probable nucleophilic catalyst. Biochemistry. 1998 Jan 6;37(1):344-51. doi: 10.1021/bi971874+.
Pubmed: 9425056
Preumont A, Snoussi K, Stroobant V, Collet JF, Van Schaftingen E: Molecular identification of pseudouridine-metabolizing enzymes. J Biol Chem. 2008 Sep 12;283(37):25238-46. doi: 10.1074/jbc.M804122200. Epub 2008 Jun 30.
Pubmed: 18591240
Ramamurthy V, Swann SL, Paulson JL, Spedaliere CJ, Mueller EG: Critical aspartic acid residues in pseudouridine synthases. J Biol Chem. 1999 Aug 6;274(32):22225-30.
Pubmed: 10428788
Solomon LR, Breitman TR: Pseudouridine kinase of escherichia coli: a new enzyme. Biochem Biophys Res Commun. 1971 Jul 16;44(2):299-304.
Pubmed: 4334133
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
Prior TI, Kornberg HL: Nucleotide sequence of fruA, the gene specifying enzyme IIfru of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Escherichia coli K12. J Gen Microbiol. 1988 Oct;134(10):2757-68. doi: 10.1099/00221287-134-10-2757.
Pubmed: 3076173
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0001901
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