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D-serine/D-
alanine/glycine
transporter
Proton
glutamate
symport protein
Sodium/glutamate
symport carrier
protein
Glutamate--
cysteine ligase
Glutathione
S-transferase
Glutathione
S-transferase
Glutathione
S-transferase
Glutathione
synthetase
Glutathione
reductase
Glutamate/aspartate
transport
ATP-binding
protein gltL
Glutamate/aspartate
transport
system permease
protein gltK
Glutamate/aspartate
transport
system permease
protein gltJ
Glutamate/aspartate
periplasmic-
binding protein
L-Glutamic acid
Glycine
Glycine
H
+
H
+
H
+
H
+
L-Glutamic acid
L-Glutamic acid
L-Glutamic acid
Na
+
Na
+
ATP
L-Cysteine
ADP
P
i
H
+
γ-
Glutamylcysteine
Glutathione
Oxidized
glutathione
2-(S-
Glutathionyl)acetyl
chloride
2-(S-
Glutathionyl)acetyl
glutathione
Hydrochloric acid
Bromobenzene-
3,4-oxide
3,4-Dihydro-3-
hydroxy-4-S-
glutathionyl
bromobenzene
Benzo[a]pyrene-
4,5-oxide
1-Amino-propan-
2-ol
ATP
H
+
P
i
ADP
H
+
NADPH
NADP
ATP
H
2
O
ADP
P
i
H
+
an oxidized
glutaredoxin
a reduced
glutaredoxin
Endocytosis
GSH-dependent
disulfide bond
oxidoreductase
Gram negative bacteria
Periplasm
Cytosol
cycA
gltP
gltS
gshA
gst
gst
gst
gshB
gor
gltL
gltK
gltJ
gltI
L-Glutamic acid
Glycine
Glycine
Hydrogen Ion
Hydrogen Ion
Hydrogen Ion
Hydrogen Ion
L-Glutamic acid
L-Glutamic acid
L-Glutamic acid
Sodium
Sodium
Adenosine
triphosphate
L-Cysteine
Adenosine
diphosphate
Phosphate
Hydrogen Ion
γ-
Glutamylcysteine
Glutathione
Oxidized
glutathione
2-(S-
Glutathionyl)acetyl
chloride
2-(S-
Glutathionyl)acetyl
glutathione
Hydrochloric acid
Bromobenzene-
3,4-oxide
3,4-Dihydro-3-
hydroxy-4-S-
glutathionyl
bromobenzene
Benzo[a]pyrene-
4,5-oxide
1-Amino-propan-
2-ol
Adenosine
triphosphate
Hydrogen Ion
Phosphate
Adenosine
diphosphate
Hydrogen Ion
NADPH
NADP
Adenosine
triphosphate
Water
Adenosine
diphosphate
Phosphate
Hydrogen Ion
an oxidized
glutaredoxin
a reduced
glutaredoxin
Endocytosis
yfcG