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Pathway Description
Pyrimidine Ribonucleosides Degradation
Escherichia coli
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-09-29
Last Updated: 2024-10-26
Cytidine and uridine are transported through their corresponding nucleoside hydrogen symporters. Once cytidine is incorporated into the cytosol, it is deaminated through a reaction with water and a hydrogen ion through a cytidine deaminase resulting in the release of ammonium and uridine. Uridine is then lyased by a phosphate through a uridine phosphorylase resulting in the release of a uracil and an alpha-D-ribose-1-phosphate. This compound is then transformed into an isomer D-ribose 5-phosphate through an alpha-D-ribose 1,5-phosphomutase. This compound is then incorporated into the pentose phosphate pathway.
References
Pyrimidine Ribonucleosides Degradation References
Loh KD, Gyaneshwar P, Markenscoff Papadimitriou E, Fong R, Kim KS, Parales R, Zhou Z, Inwood W, Kustu S: A previously undescribed pathway for pyrimidine catabolism. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5114-9. doi: 10.1073/pnas.0600521103. Epub 2006 Mar 15.
Pubmed: 16540542
Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low Jr KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE. Escherichia coli and Salmonella, Cellular and Molecular Biology, Second Edition. American Society for Microbiology, Washington, D.C., 1996.
Liu J, Beacham IR: Transcription and regulation of the cpdB gene in Escherichia coli K12 and Salmonella typhimurium LT2: evidence for modulation of constitutive promoters by cyclic AMP-CRP complex. Mol Gen Genet. 1990 Jun;222(1):161-5. doi: 10.1007/bf00283039.
Pubmed: 2172762
Liu J, Burns DM, Beacham IR: Isolation and sequence analysis of the gene (cpdB) encoding periplasmic 2',3'-cyclic phosphodiesterase. J Bacteriol. 1986 Mar;165(3):1002-10. doi: 10.1128/jb.165.3.1002-1010.1986.
Pubmed: 3005231
Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. doi: 10.1093/nar/23.12.2105.
Pubmed: 7610040
Westh Hansen SE, Jensen N, Munch-Petersen A: Studies on the sequence and structure of the Escherichia coli K-12 nupG gene, encoding a nucleoside-transport system. Eur J Biochem. 1987 Oct 15;168(2):385-91. doi: 10.1111/j.1432-1033.1987.tb13431.x.
Pubmed: 3311747
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
Valentin-Hansen P, Holst B, Josephsen J, Hammer K, Albrechtsen B: CRP/cAMP- and CytR-regulated promoters in Escherichia coli K12: the cdd promoter. Mol Microbiol. 1989 Oct;3(10):1385-90. doi: 10.1111/j.1365-2958.1989.tb00120.x.
Pubmed: 2575702
Yang C, Carlow D, Wolfenden R, Short SA: Cloning and nucleotide sequence of the Escherichia coli cytidine deaminase (ccd) gene. Biochemistry. 1992 May 5;31(17):4168-74. doi: 10.1021/bi00132a003.
Pubmed: 1567863
Walton L, Richards CA, Elwell LP: Nucleotide sequence of the Escherichia coli uridine phosphorylase (udp) gene. Nucleic Acids Res. 1989 Aug 25;17(16):6741. doi: 10.1093/nar/17.16.6741.
Pubmed: 2674901
Veiko VP, Chebotaev DV, Ovcharova IV, Gul'ko LB: [Protein engineering of uridine phosphorylase from Escherichia coli K-12. I. Cloning and expression of uridine phosphorylase genes from Klebsiella aerogenes and Salmonella typhimurium in E. coli]. Bioorg Khim. 1998 May;24(5):381-7.
Pubmed: 9661793
Morgunova EYu, Mikhailov AM, Popov AN, Blagova EV, Smirnova EA, Vainshtein BK, Mao C, Armstrong ShR, Ealick SE, Komissarov AA, et al.: Atomic structure at 2.5 A resolution of uridine phosphorylase from E. coli as refined in the monoclinic crystal lattice. FEBS Lett. 1995 Jun 26;367(2):183-7. doi: 10.1016/0014-5793(95)00489-v.
Pubmed: 7796917
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