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Pathway Description
Conversion of Succinate to Propanoate
Escherichia coli
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-10-08
Last Updated: 2025-09-04
The enzymes involved in the decarboxylation of succinate to propionate are encoded in the Escherichia coli operon. A CoA transferase reaction is catalyzed by YgfH with succinyl CoA and propionyl CoA donating and succinate and propionate accepting. Sbm, sleeping beauty mutase or methylmalonyl-CoA mutase, is an apoenzyme that is activated by binding of adenosylcobalamin. Sbm catalyzes the methylmalonyl CoA mutase reaction. The metabolic function if this pathway is still unknown.
References
Conversion of Succinate to Propanoate References
Benning MM, Haller T, Gerlt JA, Holden HM: New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli. Biochemistry. 2000 Apr 25;39(16):4630-9. doi: 10.1021/bi9928896.
Pubmed: 10769118
Haller T, Buckel T, Retey J, Gerlt JA: Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli. Biochemistry. 2000 Apr 25;39(16):4622-9.
Pubmed: 10769117
Froese DS, Dobson CM, White AP, Wu X, Padovani D, Banerjee R, Haller T, Gerlt JA, Surette MG, Gravel RA: Sleeping beauty mutase (sbm) is expressed and interacts with ygfd in Escherichia coli. Microbiol Res. 2009;164(1):1-8. doi: 10.1016/j.micres.2008.08.006. Epub 2008 Oct 23.
Pubmed: 18950999
Roy I, Leadlay PF: Physical map location of the new Escherichia coli gene sbm. J Bacteriol. 1992 Sep;174(17):5763-4. doi: 10.1128/jb.174.17.5763-5764.1992.
Pubmed: 1355087
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
Haller T, Buckel T, Retey J, Gerlt JA: Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli. Biochemistry. 2000 Apr 25;39(16):4622-9. doi: 10.1021/bi992888d.
Pubmed: 10769117
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