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Pathway Description
Ethylene Glycol Degradation
Escherichia coli
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-10-13
Last Updated: 2019-08-13
Ethylene glycol, or 1,2-ethanediol, is used to produce substances such as plastics, solvents, surfactants, explosives and cosmetics. Many of these are discarded into waste treatment and landfills. Both aerobic and anaerobic microorganisms can degrade ethylene glycol. While ethylene glycol cannot be used as a carbon source by wild-type E.coli, it can be utilized by isolated mutant strains. These strains contain two regulatory mutations: a mutation that increases propanediol oxidoreductase levels which functions to metabolize propanediol, and increased activity of Glycolaldehyde dehydrogenase to produce glycolate from glycolaldehyde.
References
Ethylene Glycol Degradation References
Boronat A, Caballero E, Aguilar J: Experimental evolution of a metabolic pathway for ethylene glycol utilization by Escherichia coli. J Bacteriol. 1983 Jan;153(1):134-9.
Pubmed: 6336729
Dwyer DF, Tiedje JM: Degradation of ethylene glycol and polyethylene glycols by methanogenic consortia. Appl Environ Microbiol. 1983 Jul;46(1):185-90.
Pubmed: 6614903
Conway T, Ingram LO: Similarity of Escherichia coli propanediol oxidoreductase (fucO product) and an unusual alcohol dehydrogenase from Zymomonas mobilis and Saccharomyces cerevisiae. J Bacteriol. 1989 Jul;171(7):3754-9. doi: 10.1128/jb.171.7.3754-3759.1989.
Pubmed: 2661535
Chen YM, Lu Z, Lin EC: Constitutive activation of the fucAO operon and silencing of the divergently transcribed fucPIK operon by an IS5 element in Escherichia coli mutants selected for growth on L-1,2-propanediol. J Bacteriol. 1989 Nov;171(11):6097-105. doi: 10.1128/jb.171.11.6097-6105.1989.
Pubmed: 2553671
Lu Z, Lin EC: The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation. Nucleic Acids Res. 1989 Jun 26;17(12):4883-4. doi: 10.1093/nar/17.12.4883.
Pubmed: 2664711
Hidalgo E, Chen YM, Lin EC, Aguilar J: Molecular cloning and DNA sequencing of the Escherichia coli K-12 ald gene encoding aldehyde dehydrogenase. J Bacteriol. 1991 Oct;173(19):6118-23. doi: 10.1128/jb.173.19.6118-6123.1991.
Pubmed: 1917845
Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kasai H, Kashimoto K, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Horiuchi T, et al.: A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. DNA Res. 1996 Dec 31;3(6):363-77. doi: 10.1093/dnares/3.6.363.
Pubmed: 9097039
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
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