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Pathway Description
Ribose Degradation
Escherichia coli
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-10-14
Last Updated: 2024-11-18
Escherichia coli can utilize the monosaccharide D-ribose as the sole source of carbon and energy for the cell. A high-affinity ABC transport system transports D-ribose into the cell as unphosphorylated beta-D-ribopyranose. Ribose pyranase converts between the furanose and pyranose forms of beta-D-ribose. D-ribofuranose converts between the alpha and beta anomers quickly and spontaneously. Ribokinase converts D-ribose to the pentose phosphate pathway intermediate, D-ribose 5-phosphate, which can enter the central metabolism pathways to meet the cells needs.
References
Ribose Degradation References
Mowbray SL, Cole LB: 1.7 A X-ray structure of the periplasmic ribose receptor from Escherichia coli. J Mol Biol. 1992 May 5;225(1):155-75.
Pubmed: 1583688
Pauly DF, Pepine CJ: D-Ribose as a supplement for cardiac energy metabolism. J Cardiovasc Pharmacol Ther. 2000 Oct;5(4):249-58. doi: 10.1054/JCPT.2000.18011.
Pubmed: 11150394
Bell AW, Buckel SD, Groarke JM, Hope JN, Kingsley DH, Hermodson MA: The nucleotide sequences of the rbsD, rbsA, and rbsC genes of Escherichia coli K12. J Biol Chem. 1986 Jun 15;261(17):7652-8.
Pubmed: 3011793
Burland V, Plunkett G 3rd, Daniels DL, Blattner FR: DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication. Genomics. 1993 Jun;16(3):551-61. doi: 10.1006/geno.1993.1230.
Pubmed: 7686882
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hope JN, Bell AW, Hermodson MA, Groarke JM: Ribokinase from Escherichia coli K12. Nucleotide sequence and overexpression of the rbsK gene and purification of ribokinase. J Biol Chem. 1986 Jun 15;261(17):7663-8.
Pubmed: 3011794
Buckel SD, Bell AW, Rao JK, Hermodson MA: An analysis of the structure of the product of the rbsA gene of Escherichia coli K12. J Biol Chem. 1986 Jun 15;261(17):7659-62.
Pubmed: 3086314
Groarke JM, Mahoney WC, Hope JN, Furlong CE, Robb FT, Zalkin H, Hermodson MA: The amino acid sequence of D-ribose-binding protein from Escherichia coli K12. J Biol Chem. 1983 Nov 10;258(21):12952-6.
Pubmed: 6313683
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