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Pathway Description
BaeSR Two-Component Signal Transduction System
Escherichia coli
Category:
Protein Pathway
Sub-Categories:
Kinase Signaling
Gene Regulatory
Stress-Activated Signaling
Cellular Response
Created: 2015-10-14
Last Updated: 2024-11-04
In E.coli K-12, two component systems (TCSs) are responsible for sensing and response to changes in environmental conditions. Sensor kinase response environmental signals by auto-phosphorylate on membrane, which transfer a phosphoryl group to a response regulator (RR) for activation. Signal transduction histidine-protein kinase (BaeS) is sensor kinase and transcriptional regulatory protein (BaeR) is the response regulator in the TCSs. BaeR overexpression may lead to greater resistance to novobiocin and deoxycholate.
References
BaeSR Two-Component Signal Transduction System References
Baranova N, Nikaido H: The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. J Bacteriol. 2002 Aug;184(15):4168-76.
Pubmed: 12107134
Baranova N, Nikaido H: The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. J Bacteriol. 2002 Aug;184(15):4168-76. doi: 10.1128/jb.184.15.4168-4176.2002.
Pubmed: 12107134
Nagasawa S, Ishige K, Mizuno T: Novel members of the two-component signal transduction genes in Escherichia coli. J Biochem. 1993 Sep;114(3):350-7. doi: 10.1093/oxfordjournals.jbchem.a124180.
Pubmed: 8282725
Itoh T, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Kasai H, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Seki Y, Horiuchi T, et al.: A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. DNA Res. 1996 Dec 31;3(6):379-92. doi: 10.1093/dnares/3.6.379.
Pubmed: 9097040
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
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