Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Operon: Cell Division Control
Escherichia coli
Category:
Protein Pathway
Sub-Categories:
Gene Regulatory
Cellular Response
Created: 2015-10-28
Last Updated: 2019-12-04
The dicB-ydfDE-insD7-intQ operon in E. coli contains five genes, the first of which is part of the inhibition of cell division in E. coli. The other genes may produce proteins of unknown function, and are prophage genes that are present in the E. coli population. This operon can be inactivated by the HTH-type transcriptional regulator DicA, allowing cell division to occur.
The first gene in the operon, dicB, encodes the division inhibition protein DicB which prevents cell division from occurring.
The second gene, ydfD, encodes an uncharacterized protein YdfD, which may be involved in viral infection of the cell.
The third gene, ydfE, encodes a putative uncharacterized protein YdfE, which may be shortened by an insertion element between this gene and intQ.
The fourth gene, insD7, which encodes the transpose InsD for insertion element IS2 on F plasmid, a protein involved in transposing the insertion sequence IS2.
The final gene, intQ, encodes the putative defective protein IntQ, an integrase used to insert and remove the prophage from the E. coli genome. In this case, the protein may be non-functional due to the presence of the insertion element between the ydfE and intQ genes.
References
Operon: Cell Division Control References
Bouche F, Bouche JP: Genetic evidence that DicF, a second division inhibitor encoded by the Escherichia coli dicB operon, is probably RNA. Mol Microbiol. 1989 Jul;3(7):991-4.
Pubmed: 2477663
Misumi Y, Ogata S, Ohkubo K, Hirose S, Ikehara Y: Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form. Eur J Biochem. 1990 Aug 17;191(3):563-9. doi: 10.1111/j.1432-1033.1990.tb19158.x.
Pubmed: 2129526
Hansen KR, Resta R, Webb CF, Thompson LF: Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene. Gene. 1995 Dec 29;167(1-2):307-12. doi: 10.1016/0378-1119(95)00574-9.
Pubmed: 8566797
Knapp K, Zebisch M, Pippel J, El-Tayeb A, Muller CE, Strater N: Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling. Structure. 2012 Dec 5;20(12):2161-73. doi: 10.1016/j.str.2012.10.001. Epub 2012 Nov 8.
Pubmed: 23142347
Yun, S.H., Ji, S.C., Jeon, H.J., Wang, X., Kim, S.W., Bak, G., Lee, Y. and Lim, H.M., 2012. The CnuK9E H-NS complex antagonizes DNA binding of DicA and leads to temperature-dependent filamentous growth in E. coli.
Cam K, Bejar S, Gil D, Bouche JP: Identification and sequence of gene dicB: translation of the division inhibitor from an in-phase internal start. Nucleic Acids Res. 1988 Jul 25;16(14A):6327-38. doi: 10.1093/nar/16.14.6327.
Pubmed: 3041373
Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kasai H, Kashimoto K, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Horiuchi T, et al.: A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. DNA Res. 1996 Dec 31;3(6):363-77. doi: 10.1093/dnares/3.6.363.
Pubmed: 9097039
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Bouche F, Bouche JP: Genetic evidence that DicF, a second division inhibitor encoded by the Escherichia coli dicB operon, is probably RNA. Mol Microbiol. 1989 Jul;3(7):991-4. doi: 10.1111/j.1365-2958.1989.tb00249.x.
Pubmed: 2477663
Bejar S, Cam K, Bouche JP: Control of cell division in Escherichia coli. DNA sequence of dicA and of a second gene complementing mutation dicA1, dicC. Nucleic Acids Res. 1986 Sep 11;14(17):6821-33. doi: 10.1093/nar/14.17.6821.
Pubmed: 3532030
Highlighted elements will appear in red.
Highlight Compounds
No Compounds Present
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
No Compounds Present
Visualize Protein Data
Downloads
Settings