Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Operon: Lysine Decarboxylase
Escherichia coli
Category:
Protein Pathway
Sub-Categories:
Gene Regulatory
Cellular Response
Created: 2015-11-09
Last Updated: 2025-05-31
The lysine carboxylase operon consists of cadB and cadA genes. This operon's transcription activation can be controlled by GadE-RcsB DNA binding transcriptional activator, GadX (GadX DNA-binding transcriptional dual regulator) , CadC (CadC DNA-binding transcriptional activator) or Lrp (Lrp transcriptional dual regulator) in unspecified binding site locations.
This operon's transcription inactivation is controlled by H-NS (H-NS DNA-binding transcriptional dual regulator) binding to -32, -129, -175, -260 or -317 bp of the promoter site.
This operon's transcription inactivation can also be controlled by ArcA-Phosphorylated DNA-binding transcriptional dual regulator binding to -179 bp of the promoter site.
References
Operon: Lysine Decarboxylase References
Auger EA, Redding KE, Plumb T, Childs LC, Meng SY, Bennett GN: Construction of lac fusions to the inducible arginine- and lysine decarboxylase genes of Escherichia coli K12. Mol Microbiol. 1989 May;3(5):609-20.
Pubmed: 2527331
Beretskene SIa, Bruzgulis PA, Ragavichus AB: [Conditions of the synthesis of lysine decarboxylase by Escherichia coli MRE 600]. Prikl Biokhim Mikrobiol. 1980 May-Jun;16(3):351-5.
Pubmed: 7001435
Bi H, Zhang C: Integration host factor is required for the induction of acid resistance in Escherichia coli. Curr Microbiol. 2014 Aug;69(2):218-24. doi: 10.1007/s00284-014-0595-7. Epub 2014 May 10.
Pubmed: 24816374
Dell CL, Neely MN, Olson ER: Altered pH and lysine signalling mutants of cadC, a gene encoding a membrane-bound transcriptional activator of the Escherichia coli cadBA operon. Mol Microbiol. 1994 Oct;14(1):7-16.
Pubmed: 7830562
Fritz G, Koller C, Burdack K, Tetsch L, Haneburger I, Jung K, Gerland U: Induction kinetics of a conditional pH stress response system in Escherichia coli. J Mol Biol. 2009 Oct 23;393(2):272-86. doi: 10.1016/j.jmb.2009.08.037. Epub 2009 Aug 21.
Pubmed: 19703467
Hommais F, Krin E, Coppee JY, Lacroix C, Yeramian E, Danchin A, Bertin P: GadE (YhiE): a novel activator involved in the response to acid environment in Escherichia coli. Microbiology. 2004 Jan;150(Pt 1):61-72. doi: 10.1099/mic.0.26659-0.
Pubmed: 14702398
Huerta AM, Collado-Vides J: Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals. J Mol Biol. 2003 Oct 17;333(2):261-78.
Pubmed: 14529615
Kikuchi Y, Kurahashi O, Nagano T, Kamio Y: RpoS-dependent expression of the second lysine decarboxylase gene in Escherichia coli. Biosci Biotechnol Biochem. 1998 Jun;62(6):1267-70.
Pubmed: 9692215
Krin E, Danchin A, Soutourina O: Decrypting the H-NS-dependent regulatory cascade of acid stress resistance in Escherichia coli. BMC Microbiol. 2010 Oct 29;10:273. doi: 10.1186/1471-2180-10-273.
Pubmed: 21034467
Krin E, Danchin A, Soutourina O: RcsB plays a central role in H-NS-dependent regulation of motility and acid stress resistance in Escherichia coli. Res Microbiol. 2010 Jun;161(5):363-71. doi: 10.1016/j.resmic.2010.04.002. Epub 2010 May 14.
Pubmed: 20435136
Kuper C, Jung K: CadC-mediated activation of the cadBA promoter in Escherichia coli. J Mol Microbiol Biotechnol. 2005;10(1):26-39. doi: 10.1159/000090346.
Pubmed: 16491024
Laurent G, Calemard E, Charra B: Dialysis related amyloidosis. Kidney Int Suppl. 1988 Mar;24:S32-4.
Pubmed: 3163049
Liu X, De Wulf P: Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling. J Biol Chem. 2004 Mar 26;279(13):12588-97. doi: 10.1074/jbc.M313454200. Epub 2004 Jan 7.
Pubmed: 14711822
Marbaniang CN, Gowrishankar J: Role of ArgP (IciA) in lysine-mediated repression in Escherichia coli. J Bacteriol. 2011 Nov;193(21):5985-96. doi: 10.1128/JB.05869-11. Epub 2011 Sep 2.
Pubmed: 21890697
Meng SY, Bennett GN: Regulation of the Escherichia coli cad operon: location of a site required for acid induction. J Bacteriol. 1992 Apr;174(8):2670-8.
Pubmed: 1556086
Neely MN, Dell CL, Olson ER: Roles of LysP and CadC in mediating the lysine requirement for acid induction of the Escherichia coli cad operon. J Bacteriol. 1994 Jun;176(11):3278-85.
Pubmed: 8195083
Neely MN, Olson ER: Kinetics of expression of the Escherichia coli cad operon as a function of pH and lysine. J Bacteriol. 1996 Sep;178(18):5522-8.
Pubmed: 8808945
Popkin PS, Maas WK: Escherichia coli regulatory mutation affecting lysine transport and lysine decarboxylase. J Bacteriol. 1980 Feb;141(2):485-92.
Pubmed: 6767681
Pruss BM, Markovic D, Matsumura P: The Escherichia coli flagellar transcriptional activator flhD regulates cell division through induction of the acid response gene cadA. J Bacteriol. 1997 Jun;179(11):3818-21.
Pubmed: 9171439
Reams SG, Lee N, Mat-Jan F, Clark DP: Effect of chelating agents and respiratory inhibitors on regulation of the cadA gene in Escherichia coli. Arch Microbiol. 1997 Apr;167(4):209-16.
Pubmed: 9075621
Rowbury RJ: Regulatory components, including integration host factor, CysB and H-NS, that influence pH responses in Escherichia coli. Lett Appl Microbiol. 1997 May;24(5):319-28.
Pubmed: 9172436
Ruiz J, Haneburger I, Jung K: Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli. J Bacteriol. 2011 May;193(10):2536-48. doi: 10.1128/JB.00815-10. Epub 2011 Mar 25.
Pubmed: 21441513
Shi X, Waasdorp BC, Bennett GN: Modulation of acid-induced amino acid decarboxylase gene expression by hns in Escherichia coli. J Bacteriol. 1993 Feb;175(4):1182-6.
Pubmed: 8381784
Shi X, Bennett GN: Effects of multicopy LeuO on the expression of the acid-inducible lysine decarboxylase gene in Escherichia coli. J Bacteriol. 1995 Feb;177(3):810-4.
Pubmed: 7836317
Takayama M, Ohyama T, Igarashi K, Kobayashi H: Escherichia coli cad operon functions as a supplier of carbon dioxide. Mol Microbiol. 1994 Mar;11(5):913-8.
Pubmed: 8022268
Tetsch L, Koller C, Haneburger I, Jung K: The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP. Mol Microbiol. 2008 Feb;67(3):570-83. doi: 10.1111/j.1365-2958.2007.06070.x. Epub 2007 Dec 16.
Pubmed: 18086202
Watson N, Dunyak DS, Rosey EL, Slonczewski JL, Olson ER: Identification of elements involved in transcriptional regulation of the Escherichia coli cad operon by external pH. J Bacteriol. 1992 Jan;174(2):530-40.
Pubmed: 1370290
Watson N, Dunyak DS, Rosey EL, Slonczewski JL, Olson ER: Identification of elements involved in transcriptional regulation of the Escherichia coli cad operon by external pH. J Bacteriol. 1992 Jan;174(2):530-40. doi: 10.1128/jb.174.2.530-540.1992.
Pubmed: 1370290
Meng SY, Bennett GN: Nucleotide sequence of the Escherichia coli cad operon: a system for neutralization of low extracellular pH. J Bacteriol. 1992 Apr;174(8):2659-69. doi: 10.1128/jb.174.8.2659-2669.1992.
Pubmed: 1556085
Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. doi: 10.1093/nar/23.12.2105.
Pubmed: 7610040
Gervais FG, Phoenix P, Drapeau GR: The rcsB gene, a positive regulator of colanic acid biosynthesis in Escherichia coli, is also an activator of ftsZ expression. J Bacteriol. 1992 Jun;174(12):3964-71. doi: 10.1128/jb.174.12.3964-3971.1992.
Pubmed: 1597415
Stout V, Gottesman S: RcsB and RcsC: a two-component regulator of capsule synthesis in Escherichia coli. J Bacteriol. 1990 Feb;172(2):659-69. doi: 10.1128/jb.172.2.659-669.1990.
Pubmed: 2404948
Itoh T, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Kasai H, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Seki Y, Horiuchi T, et al.: A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. DNA Res. 1996 Dec 31;3(6):379-92. doi: 10.1093/dnares/3.6.379.
Pubmed: 9097040
Sofia HJ, Burland V, Daniels DL, Plunkett G 3rd, Blattner FR: Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes. Nucleic Acids Res. 1994 Jul 11;22(13):2576-86. doi: 10.1093/nar/22.13.2576.
Pubmed: 8041620
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Downloads
Settings