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Pathway Description
Operon: Glucuronate Pathway Inactivation
Escherichia coli
Category:
Protein Pathway
Sub-Categories:
Gene Regulatory
Cellular Response
Created: 2015-11-10
Last Updated: 2025-01-25
The glucuronate pathway operon is a bicistronic operon consisting of the genes uxuA and uxuB. The transcription of this operon is activated by CRP-cAMP DNA-binding transcriptional dual regulator binding to -57.5 or -142.5 bp off the promoter. The transcription of the operon can be repressed by multiple means: -UxuR (UxuR DNA-binding transcriptional repressor) binding -159.5 or -53.5 off the promoter -ExuR (ExuR DNA-binding transcriptional repressor) binding to -159.5 or -53.5 off the promoter -OxyR (OxyR DNA-binding transcriptional dual regulator) binding to -54 or -32 off the promoter
References
Operon: Glucuronate Pathway Inactivation References
Bates Utz C, Nguyen AB, Smalley DJ, Anderson AB, Conway T: GntP is the Escherichia coli Fructuronic acid transporter and belongs to the UxuR regulon. J Bacteriol. 2004 Nov;186(22):7690-6. doi: 10.1128/JB.186.22.7690-7696.2004.
Pubmed: 15516583
Blanco C, Ritzenthaler P, Kolb A: The regulatory region of the uxuAB operon in Escherichia coli K12. Mol Gen Genet. 1986 Jan;202(1):112-9.
Pubmed: 3083215
Huerta AM, Collado-Vides J: Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals. J Mol Biol. 2003 Oct 17;333(2):261-78.
Pubmed: 14529615
Klemm P, Tong S, Nielsen H, Conway T: The gntP gene of Escherichia coli involved in gluconate uptake. J Bacteriol. 1996 Jan;178(1):61-7.
Pubmed: 8550444
Lynch AS, Lin EC: Transcriptional control mediated by the ArcA two-component response regulator protein of Escherichia coli: characterization of DNA binding at target promoters. J Bacteriol. 1996 Nov;178(21):6238-49.
Pubmed: 8892825
Ritzenthaler P, Mata-Gilsinger M: Use of in vitro gene fusions to study the uxuR regulatory gene in Escherichia coli K-12: direction of transcription and regulation of its expression. J Bacteriol. 1982 Jun;150(3):1040-7.
Pubmed: 6281232
Ritzenthaler P, Blanco C, Mata-Gilsinger M: Genetic analysis of uxuR and exuR genes: evidence for ExuR and UxuR monomer repressors interactions. Mol Gen Genet. 1985;199(3):507-11.
Pubmed: 3929016
Robert-Baudouy J, Portalier R, Stoeber F: Regulation of hexuronate system genes in Escherichia coli K-12: multiple regulation of the uxu operon by exuR and uxuR gene products. J Bacteriol. 1981 Jan;145(1):211-20.
Pubmed: 7007313
Rodionov DA, Mironov AA, Rakhmaninova AB, Gelfand MS: Transcriptional regulation of transport and utilization systems for hexuronides, hexuronates and hexonates in gamma purple bacteria. Mol Microbiol. 2000 Nov;38(4):673-83.
Pubmed: 11115104
Zheng M, Wang X, Templeton LJ, Smulski DR, LaRossa RA, Storz G: DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide. J Bacteriol. 2001 Aug;183(15):4562-70. doi: 10.1128/JB.183.15.4562-4570.2001.
Pubmed: 11443091
Zheng D, Constantinidou C, Hobman JL, Minchin SD: Identification of the CRP regulon using in vitro and in vivo transcriptional profiling. Nucleic Acids Res. 2004 Nov 1;32(19):5874-93. doi: 10.1093/nar/gkh908. Print 2004.
Pubmed: 15520470
Tao K, Makino K, Yonei S, Nakata A, Shinagawa H: Molecular cloning and nucleotide sequencing of oxyR, the positive regulatory gene of a regulon for an adaptive response to oxidative stress in Escherichia coli: homologies between OxyR protein and a family of bacterial activator proteins. Mol Gen Genet. 1989 Sep;218(3):371-6. doi: 10.1007/bf00332397.
Pubmed: 2511419
Christman MF, Storz G, Ames BN: OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins. Proc Natl Acad Sci U S A. 1989 May;86(10):3484-8. doi: 10.1073/pnas.86.10.3484.
Pubmed: 2471187
Bolker M, Kahmann R: The Escherichia coli regulatory protein OxyR discriminates between methylated and unmethylated states of the phage Mu mom promoter. EMBO J. 1989 Aug;8(8):2403-10.
Pubmed: 2551682
Cossart P, Gicquel-Sanzey B: Cloning and sequence of the crp gene of Escherichia coli K 12. Nucleic Acids Res. 1982 Feb 25;10(4):1363-78. doi: 10.1093/nar/10.4.1363.
Pubmed: 6280141
Aiba H, Fujimoto S, Ozaki N: Molecular cloning and nucleotide sequencing of the gene for E. coli cAMP receptor protein. Nucleic Acids Res. 1982 Feb 25;10(4):1345-61. doi: 10.1093/nar/10.4.1345.
Pubmed: 6280140
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. doi: 10.1093/nar/23.12.2105.
Pubmed: 7610040
Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. doi: 10.1038/msb4100049. Epub 2006 Feb 21.
Pubmed: 16738553
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