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Malate
dehydrogenase,
mitochondrial
Methylcytosine
dioxygenase
TET1
Lysine-specific
demethylase 2A
Hypoxia-
inducible
factor 1-alpha
Mitochondrial
pyruvate
carrier 1
Mitochondrial
dicarboxylate
carrier
Pyruvate
dehydrogenase
complex
Citrate
synthase,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
alpha,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
beta,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
gamma,
mitochondrial
Oxoglutarate
dehydrogenase
complex
Succinyl-CoA
ligase
Fumarate
hydratase,
mitochondrial
Pyruvate
carboxylase,
mitochondrial
Aconitate
hydratase,
mitochondrial
Aconitate
hydratase,
mitochondrial
Isocitrate
dehydrogenase
[NADP]
cytoplasmic
NADP+-specific
isocitrate
dehydrogenase
mutant
Isocitrate
dehydrogenase 2
[NADP],
mitochondrial
Isocitrate
dehydrogenase
[NADP],
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
cytochrome b
small subunit,
mitochondrial
Succinate
dehydrogenase
cytochrome b560
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
iron-sulfur
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
flavoprotein
subunit,
mitochondrial
Egl nine
homolog 1
Egl nine
homolog 2
Egl nine
homolog 3
Pyruvic acid
FADH
2
Pyruvic acid
Succinic acid
CoA
NAD
Acetyl-CoA
CO
2
NADH
H
2
O
Oxalacetic acid
Citric acid
CoA
Isocitric acid
NAD
Oxoglutaric
acid
CO
2
NADH
H
+
NAD
CoA
Succinyl-CoA
NADH
H
+
CO
2
P
i
GDP
CoA
GTP
L-Malic acid
Fumaric acid
H
2
O
NAD
NADH
H
+
ATP
HCO
3
-
ADP
P
i
cis-Aconitic
acid
H
2
O
H
2
O
Isocitric acid
NADP
Oxoglutaric acid
NADPH
NADPH
2-Hydroxyglutarate
NADP
NADP
Oxoglutaric acid
NADPH
NADP
Oxoglutaric acid
NADPH
Q
FAD
FADH
2
Fumaric acid
QH
2
O
2
Oxoglutaric
acid
L-Proline
CO
2
Succinic acid
4-
Hydroxyproline
Citric acid
Oxygen
Thiamine
pyrophosphate
Lipoamide
FAD
Magnesium
Thiamine
pyrophosphate
Lipoamide
FAD
Biotin
Manganese
4Fe-4S
4Fe-4S
4Fe-4S
Magnesium
Fe2+
Ascorbic acid
Glycolysis
Mitochondrial
Electron
Transport Chain
Succinic acid
Cytoplasmic
aconitate
hydratase
Inner mitochondrial membrane
Mitochondrial intermembrane
space
Cytosol
Mitochondrial matrix
Mitochondrion
Intracellular Space
Inner mitochondrial membrane
Outer mitochondrial membrane
Epigenetic Regulation
Oncogene Activation,
Tumour-suppressor
inactivation
Pseudo-Hypoxia
Mutant SDH
TCA cycle
Citric acid
Isocitric acid
Oxoglutaric acid
2-Hydroxyglutarate
Succinic acid
Cytoplasmic aconitate
hydratase
Isocitrate dehydrogenase
[NADP] cytoplasmic
mutIDH1
prolyl hydroxylase
Hypoxia-inducible factor
1-alpha
Methylcytosine dioxygenase
TET1
Lysine-specific demethylase
2A